Textile slow-release systems with medical applications

In the development of medical drug delivery systems, attention has been increasingly focused on slow- or controlled delivery systems in order to achieve an optimal therapeutic effect. Since the administration of drugs often requires a defined or minimum effective dosage in the human body, more conventional delivery systems such as tablets require relatively high doses, which can result in undesired toxic effects. Subsequent degradation of the drug in the human body will result in a drug concentration below the minimum effective level. Furthermore, there are situations where oral administration is less advisable, such as in cases of prolonged treatment or with people that are forgetful, which again results in ineffective treatment. Textile slow-release systems have the potential to overcome these negative aspects. Drugs containing transdermal patches for ex-vivo applications are already familiar; however, this paper will not deal with such applications, but with more advanced in-vivo textile slow-release systems. Due to enormous progress over the years in the fields of supramolecular chemistry, nanotechnology, and polymer science & technology, a number of promising drug delivery technologies have been developed. This review will focus on the opportunities of textiles bearing cyclodextrins, aza-crown ethers or fullerenes, as well as ion-exchange fibres, drug-loaded hollow fibres, textiles treated with nanoparticles and fibres with bioactive compounds in their embodiment. In this paper, the delivery systems will be discussed and compared in terms of biostability, biodegradability, controllability, toxicity, carcinogenicity, interface reactions, material costs and the fabrication process.

[1]  J. Manzanares,et al.  Ion-exchange fibers and drugs: an equilibrium study. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[2]  F. Hirayama,et al.  Cyclodextrin-based controlled drug release system. , 1999, Advanced drug delivery reviews.

[3]  R. M. Izatt,et al.  Aza-Crown Macrocycles , 1993 .

[4]  S. Farrell,et al.  Mathematical modeling of controlled release from a hollow fiber , 1999 .

[5]  K. Geckeler,et al.  The water-soluble β-cyclodextrin–[60]fullerene complex , 2001 .

[6]  V. Anand,et al.  Ion-exchange resins: carrying drug delivery forward. , 2001, Drug discovery today.

[7]  A. Urtti,et al.  Controlled transdermal iontophoresis by ion-exchange fiber. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[8]  Adela Medovic,et al.  FIBROUS SYSTEMS WITH PROGRAMMED BIOLOGICAL-ACTIVITY AND THEIR APPLICATION IN MEDICAL PRACTICE , 2002 .

[9]  K. Sirkar,et al.  Mathematical model of a hybrid dispersed network-membrane-based controlled release system. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[10]  H. Vromans,et al.  In vitro release properties of etonogestrel and ethinyl estradiol from a contraceptive vaginal ring. , 2002, International journal of pharmaceutics.

[11]  Zia,et al.  Mechanisms of drug release from cyclodextrin complexes. , 1999, Advanced drug delivery reviews.

[12]  K. Sirkar,et al.  A mathematical model of an aqueous-organic partition-based controlled release system using microporous membranes. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[13]  G. L. Woo,et al.  Synthesis and characterization of a novel biodegradable antimicrobial polymer. , 2000, Biomaterials.

[14]  K. Geckeler,et al.  Cyclodextrin–fullerenes: a new class ofwater-soluble fullerenes , 2000 .

[15]  Hans-Karl Rouette,et al.  Encyclopedia of Textile Finishing , 2001 .

[16]  Jean-Marie Lehn,et al.  Comprehensive Supramolecular Chemistry , 1996 .

[17]  E. Schollmeyer,et al.  New Textile Applications of Cyclodextrins , 2001 .

[18]  M. Brewster,et al.  Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. , 1996, Journal of pharmaceutical sciences.

[19]  P. Gard,et al.  In vitro cytotoxicity and teratogenicity of norethisterone and levonorgestrel released from hollow nylon monofilaments. , 1998, Journal of controlled release : official journal of the Controlled Release Society.