Short Communication ICAM-3Expression onEndothelium inLymphoid Malignancy

Intercellular adhesion molecule-3 (ICAM-3), the third receptor for lymphocyte function-associ-ated antigen molecule-I and a new member of the immunoglobulin superfamily has been recently characterized using specific monoclonal antibodies. In the present study, we show immuno-cytochemicaly that ICAM-3 is present on T and B ceUs in the mantle zones and on a subpopulation offoUicular center ceUs in reactive lymph nodes and only occasionaly in endothelium In 52 cases of Hodgkin's disease, ICAM-3, although present on the majority of the reactive lymphoid ceUs, was absent from the Reed-Sternberg ceUs and their variants. However, in 28 cases (54%), there was prominent endothelial staining in smaU vessels. Similar findings were noted in 16 out of 49 cases (33%) of non-Hodgkin's lymphomas. This finding suggests that analogous to ICAM-1 and ICAM-2, ICAM-3 expression can be induced on endothelial ceUs in lymphoid neoplasms, prob-ably by an as yet unidentiffed cytokine-mediated mechanismr (Am JPathol 1993, 143:1040-1043) The intercellular adhesion molecule-1 (ICAM-1) and