Targeting and eradicating latent CNS reservoirs of HIV-1: original strategies and new models.

[1]  T. Luedde,et al.  In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation , 2023, Nature Medicine.

[2]  M. Nair,et al.  HIV Latency and Nanomedicine Strategies for Anti-HIV Treatment and Eradication , 2023, Biomedicines.

[3]  Meritxell Huch,et al.  Organoids , 2022, Nature Reviews Methods Primers.

[4]  S. Lewin,et al.  Shock and kill within the CNS: A promising HIV eradication approach? , 2022, Journal of leukocyte biology.

[5]  H. Gendelman,et al.  Animal models for studies of HIV‐1 brain reservoirs , 2022, Journal of leukocyte biology.

[6]  K. Christian,et al.  Using 2D and 3D pluripotent stem cell models to study neurotropic viruses , 2022, Frontiers in Virology.

[7]  J. Karn,et al.  Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells , 2022, PLoS pathogens.

[8]  N. Nasr,et al.  Evolving Strategies to Eliminate the CD4 T Cells HIV Viral Reservoir via CAR T Cell Immunotherapy , 2022, Frontiers in Immunology.

[9]  M. Boks,et al.  Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids , 2022, Viruses.

[10]  P. Lieberman,et al.  Epigenetic Landscape of HIV-1 Infection in Primary Human Macrophage , 2022, Journal of virology.

[11]  Aihua Liu,et al.  Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases , 2022, Frontiers in Immunology.

[12]  C. Schwartz,et al.  Suicide Gene Therapy in Cancer and HIV-1 infection: an alternative to conventional treatments. , 2021, Biochemical pharmacology.

[13]  R. Diaz,et al.  Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response , 2021, Scientific Reports.

[14]  B. Clotet,et al.  Preserved central nervous system functioning after use of romidepsin as a latency-reversing agent in an HIV cure strategy , 2021, AIDS.

[15]  O. Paulsen,et al.  Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology , 2021, Nature Neuroscience.

[16]  O. Gascuel,et al.  Drug resistance mutations in HIV: new bioinformatics approaches and challenges. , 2021, Current opinion in virology.

[17]  T. Pan,et al.  Broadly neutralizing antibody-derived CAR-T cells reduce viral reservoir in HIV-1-infected individuals. , 2021, The Journal of clinical investigation.

[18]  Seung‐Woo Cho,et al.  Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids , 2021, Nature Communications.

[19]  D. Langford,et al.  Viruses, SUMO, and immunity: the interplay between viruses and the host SUMOylation system , 2021, Journal of NeuroVirology.

[20]  M. Tyagi,et al.  HIV-1 PERSISTENCE IN THE CNS: MECHANISMS OF LATENCY, PATHOGENESIS AND AN UPDATE ON ERADICATION STRATEGIES. , 2021, Virus research.

[21]  A. Gavin,et al.  APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes , 2021, bioRxiv.

[22]  H. Fine,et al.  Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research , 2021, mBio.

[23]  Won Hyuk Jang,et al.  Neural stem cells derived from human midbrain organoids as a stable source for treating Parkinson’s disease Midbrain organoid-NSCs (Og-NSC) as a stable source for PD treatment , 2021, Progress in Neurobiology.

[24]  J. M. Wessels,et al.  Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses , 2021, Frontiers in Immunology.

[25]  D. Russell,et al.  Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure , 2021, Molecular therapy. Nucleic acids.

[26]  N. London,et al.  Organoid and Spheroid Tumor Models: Techniques and Applications , 2021, Cancers.

[27]  A. Danckaert,et al.  Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier , 2020, mBio.

[28]  Madeline A. Lancaster,et al.  SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids , 2020, Cell Stem Cell.

[29]  S. Sant,et al.  Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia , 2020, Scientific Reports.

[30]  M. Carrillo,et al.  Engineering CAR T Cells to Target the HIV Reservoir , 2020, Frontiers in Cellular and Infection Microbiology.

[31]  K. Roskin,et al.  Comparative analysis of human microglial models for studies of HIV replication and pathogenesis , 2020, Retrovirology.

[32]  M. Nonnemacher,et al.  Safe CRISPR-Cas9 Inhibition of HIV-1 with High Specificity and Broad-Spectrum Activity by Targeting LTR NF-κB Binding Sites , 2020, Molecular therapy. Nucleic acids.

[33]  C. Schwartz,et al.  Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy , 2020, Virology journal.

[34]  S. Daunert,et al.  The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies , 2020, Trends in Neurosciences.

[35]  Madeline A. Lancaster,et al.  Human CNS barrier-forming organoids with cerebrospinal fluid production , 2020, Science.

[36]  Bilal Cakir,et al.  Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development , 2020, STAR protocols.

[37]  C. Van Lint,et al.  Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage , 2020, Scientific Reports.

[38]  Yong Gao,et al.  Advances in Developing CAR T-Cell Therapy for HIV Cure , 2020, Frontiers in Immunology.

[39]  J. Martinez-Picado,et al.  Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report , 2020, The lancet. HIV.

[40]  Richard Martin,et al.  Characterization of HIV-1 uncoating in human microglial cell lines , 2020, Virology Journal.

[41]  F. C. Bennett,et al.  Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection , 2020, Stem cell reports.

[42]  A. Das,et al.  CRISPR-Cas9 Dual-gRNA Attack Causes Mutation, Excision and Inversion of the HIV-1 Proviral DNA , 2020, Viruses.

[43]  Ethan M. Goldberg,et al.  Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. , 2020, Cell stem cell.

[44]  Alejandra Borjabad,et al.  Prevention and treatment of HIV infection and cognitive disease in mice by innate immune responses , 2020, Brain, behavior, & immunity - health.

[45]  D. Maric,et al.  Productive HIV infection in astrocytes can be established via a non-classical mechanism. , 2020, AIDS.

[46]  Le Guo,et al.  HIV infection suppresses TLR3 activation‐mediated antiviral immunity in microglia and macrophages , 2020, Immunology.

[47]  S. Sauer,et al.  Self-Organizing 3D Human Trunk Neuromuscular Organoids. , 2020, Cell stem cell.

[48]  S. Pașca,et al.  Organoid and Assembloid Technologies for Investigating Cellular Crosstalk in Human Brain Development and Disease. , 2019, Trends in cell biology.

[49]  J. Do,et al.  Neural Lineage Differentiation From Pluripotent Stem Cells to Mimic Human Brain Tissues , 2019, Front. Bioeng. Biotechnol..

[50]  N. Kootstra,et al.  The Role of Macrophages in HIV-1 Persistence and Pathogenesis , 2019, Front. Microbiol..

[51]  Paul M. George,et al.  Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds , 2019, Scientific Reports.

[52]  J. Clements,et al.  Brain macrophages harbor latent, infectious simian immunodeficiency virus. , 2019, AIDS.

[53]  J. Ananworanich,et al.  Perspective on potential impact of HIV CNS latency on eradication. , 2019, AIDS.

[54]  J. Karn,et al.  Cross-talk between microglia and neurons regulates HIV latency , 2019, PLoS pathogens.

[55]  S. Spector,et al.  TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function , 2019, mBio.

[56]  Abhishek Srivastava,et al.  Reproducing human and cross-species drug toxicities using a Liver-Chip , 2019, Science Translational Medicine.

[57]  Gail A. Van Norman,et al.  Limitations of Animal Studies for Predicting Toxicity in Clinical Trials , 2019, JACC. Basic to translational science.

[58]  C. Van Lint,et al.  Microglial Cells: The Main HIV-1 Reservoir in the Brain , 2019, Front. Cell. Infect. Microbiol..

[59]  M. Bickle,et al.  Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner , 2019, Front. Cell. Neurosci..

[60]  R. Soto-Rifo,et al.  New Challenges of HIV-1 Infection: How HIV-1 Attacks and Resides in the Central Nervous System , 2019, Cells.

[61]  M. Dimri,et al.  Insights into the HIV Latency and the Role of Cytokines , 2019, Pathogens.

[62]  H. Gendelman,et al.  Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice , 2019, Nature Communications.

[63]  D. Volsky,et al.  Peroxisome Proliferator-Activated Receptor-gamma agonists exhibit anti-inflammatory and antiviral effects in an EcoHIV mouse model , 2019, Scientific Reports.

[64]  G. Ming,et al.  Brain organoids: advances, applications and challenges , 2019, Development.

[65]  Taina T. Immonen,et al.  Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes , 2019, PLoS pathogens.

[66]  M. Nair,et al.  Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection , 2019, Scientific Reports.

[67]  C. Rae,et al.  HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection , 2019, AIDS.

[68]  J. Martinez-Picado,et al.  HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation , 2019, Nature.

[69]  M. Humbert,et al.  Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants , 2019, Journal of Virology.

[70]  Prabir Patra,et al.  hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids. , 2019, Cell stem cell.

[71]  Z. Debyser,et al.  Establishment of latent HIV-1 reservoirs: what do we really know? , 2019, Journal of virus eradication.

[72]  Z. Debyser,et al.  Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection , 2018, Viruses.

[73]  L. Dorrell,et al.  Therapeutic Targeting of HIV Reservoirs: How to Give T Cells a New Direction , 2018, Front. Immunol..

[74]  M. Blurton-Jones,et al.  Development and validation of a simplified method to generate human microglia from pluripotent stem cells , 2018, Molecular Neurodegeneration.

[75]  Sean J. Miller.  Astrocyte Heterogeneity in the Adult Central Nervous System , 2018, Front. Cell. Neurosci..

[76]  Colby R. Maldini,et al.  CAR T cells for infection, autoimmunity and allotransplantation , 2018, Nature Reviews Immunology.

[77]  J. Karn,et al.  The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells , 2018, Journal of Neuroimmune Pharmacology.

[78]  Laura Masullo,et al.  Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output , 2018, Nature Neuroscience.

[79]  Michael S. Fernandopulle,et al.  Transcription Factor–Mediated Differentiation of Human iPSCs into Neurons , 2018, Current protocols in cell biology.

[80]  H. Gendelman,et al.  EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment , 2018, PLoS pathogens.

[81]  M. Ato,et al.  Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3+CD4+ T Cells , 2018, Front. Immunol..

[82]  Wenwei Hu,et al.  Inhibition of HIV early replication by the p53 and its downstream gene p21 , 2018, Virology Journal.

[83]  M. Kamata,et al.  Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS , 2018, PLoS Pathogens.

[84]  S. Baig,et al.  Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins , 2018, Clinical Epigenetics.

[85]  D. Grimm,et al.  Synthetic AAV/CRISPR vectors for blocking HIV‐1 expression in persistently infected astrocytes , 2018, Glia.

[86]  Sigrid A. Langhans.  Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning , 2018, Front. Pharmacol..

[87]  J. Karn,et al.  HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency , 2017, Journal of NeuroVirology.

[88]  M. Tremblay,et al.  Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion , 2017, Journal of Neuroinflammation.

[89]  P. Benaroch,et al.  Myeloid Cell Interaction with HIV: A Complex Relationship , 2017, Front. Immunol..

[90]  E. Eugenin,et al.  HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim , 2017, Scientific Reports.

[91]  C. Van Lint,et al.  Molecular Control of HIV and SIV Latency. , 2017, Current topics in microbiology and immunology.

[92]  Arnold R. Kriegstein,et al.  The use of brain organoids to investigate neural development and disease , 2017, Nature Reviews Neuroscience.

[93]  H. Gendelman,et al.  Systemic HIV-1 infection produces a unique glial footprint in humanized mouse brains , 2017, Disease Models & Mechanisms.

[94]  F. Kashanchi,et al.  Exosomes from uninfected cells activate transcription of latent HIV-1 , 2017, The Journal of Biological Chemistry.

[95]  K. Brennand,et al.  An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells , 2017, bioRxiv.

[96]  Hans Clevers,et al.  Disease Modeling in Stem Cell-Derived 3D Organoid Systems. , 2017, Trends in molecular medicine.

[97]  Daniel R. Berger,et al.  Cell diversity and network dynamics in photosensitive human brain organoids , 2017, Nature.

[98]  Michael D. Cahalan,et al.  iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases , 2017, Neuron.

[99]  Chih-Ming Ho,et al.  Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels , 2017, Journal of biological engineering.

[100]  J. Nascimento,et al.  Derivation of Functional Human Astrocytes from Cerebral Organoids , 2017, Scientific Reports.

[101]  C. Sabin,et al.  Predictors of longitudinal change in bone mineral density in a cohort of HIV-positive and negative patients , 2017, AIDS.

[102]  Q. Sattentau,et al.  Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material , 2017, Cell reports.

[103]  S. Spector,et al.  Development and characterization of a human microglia cell model of HIV-1 infection , 2016, Journal of NeuroVirology.

[104]  Steven C George,et al.  A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. , 2017, Lab on a chip.

[105]  Abraham J. Kandathil,et al.  Are T cells the only HIV-1 reservoir? , 2016, Retrovirology.

[106]  R. Siliciano,et al.  Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques , 2016, AIDS.

[107]  L. Smirnova,et al.  A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity , 2016, ALTEX.

[108]  J. Karn,et al.  Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system , 2016, Journal of NeuroVirology.

[109]  C. Van Lint,et al.  HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1 , 2016, Scientific Reports.

[110]  G. Fogel,et al.  HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads , 2016, Journal of Virology.

[111]  Konrad Scheffler,et al.  Compartmentalized HIV rebound in the central nervous system after interruption of antiretroviral therapy , 2016, Virus evolution.

[112]  S. Horvath,et al.  Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders , 2016, Journal of NeuroVirology.

[113]  David W. Nauen,et al.  Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure , 2016, Cell.

[114]  Carolyn M. Scott,et al.  Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium , 2016, Stem cells translational medicine.

[115]  P. Garcez,et al.  Zika virus impairs growth in human neurospheres and brain organoids , 2016, Science.

[116]  D. Fuchs,et al.  Immune Activation and HIV-Specific CD8(+) T Cells in Cerebrospinal Fluid of HIV Controllers and Noncontrollers. , 2016, AIDS research and human retroviruses.

[117]  A. Kim,et al.  Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier , 2016, Current pharmaceutical design.

[118]  J. McCann,et al.  KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. , 2016, Molecular cell.

[119]  M. Churchill,et al.  Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells , 2016, Journal of NeuroVirology.

[120]  R. Siliciano,et al.  HIV reservoirs: what, where and how to target them , 2015, Nature Reviews Microbiology.

[121]  C. Van Lint,et al.  Epigenetic control of HIV-1 post integration latency: implications for therapy , 2015, Clinical Epigenetics.

[122]  G. Pantaleo,et al.  The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo , 2015, PLoS pathogens.

[123]  A. Chauhan.  Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent. , 2015, Microbes and infection.

[124]  M. Churchill,et al.  CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies , 2015, Molecular Psychiatry.

[125]  S. Álvarez,et al.  Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism , 2015, Scientific Reports.

[126]  V. Fossati,et al.  Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells , 2015, Nature Protocols.

[127]  Arsène Burny,et al.  An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression , 2015, PLoS pathogens.

[128]  Tao Wu,et al.  Progress and challenges in the use of latent HIV-1 reactivating agents , 2015, Acta Pharmacologica Sinica.

[129]  M. Salemi,et al.  SIV encephalitis lesions are composed of CD163(+) macrophages present in the central nervous system during early SIV infection and SIV-positive macrophages recruited terminally with AIDS. , 2015, The American journal of pathology.

[130]  J. Garcia,et al.  Humanized mouse models for HIV-1 infection of the CNS , 2015, Journal of NeuroVirology.

[131]  D. Geschwind,et al.  Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture , 2015, Nature Methods.

[132]  M. Wainberg,et al.  Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis , 2015, Retrovirology.

[133]  Johnny J. He,et al.  Cell–cell contact viral transfer contributes to HIV infection and persistence in astrocytes , 2015, Journal of NeuroVirology.

[134]  R. Siliciano,et al.  Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations , 2015, Nature.

[135]  S. Spector,et al.  Autophagy Induction by Histone Deacetylase Inhibitors Inhibits HIV Type 1* , 2014, The Journal of Biological Chemistry.

[136]  A. Epstein,et al.  Associations between brain microstructures, metabolites, and cognitive deficits during chronic HIV-1 infection of humanized mice , 2014, Molecular Neurodegeneration.

[137]  D. Margolis,et al.  Eradicating HIV-1 infection: seeking to clear a persistent pathogen , 2014, Nature Reviews Microbiology.

[138]  Jon W. Johnson,et al.  Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation , 2014, Organogenesis.

[139]  R. Siliciano,et al.  Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1. , 2014, The Journal of allergy and clinical immunology.

[140]  Jinyan Liu,et al.  Rapid Seeding of the Viral Reservoir Prior to SIV Viremia in Rhesus Monkeys , 2014, Nature.

[141]  C. Schwartz,et al.  The Many Lives of CTIP2: From AIDS to Cancer and Cardiac Hypertrophy , 2014, Journal of cellular physiology.

[142]  Kholoud Porter,et al.  Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy , 2014, AIDS.

[143]  C. Passaes,et al.  HIV cure research: advances and prospects. , 2014, Virology.

[144]  J. Karn,et al.  Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure. , 2014, Virology.

[145]  M. Churchill,et al.  HIV-1 Entry and Trans-Infection of Astrocytes Involves CD81 Vesicles , 2014, PloS one.

[146]  D. Margolis,et al.  Emerging strategies to deplete the HIV reservoir , 2014, Current opinion in infectious diseases.

[147]  P. Mallon.  Impact of nucleoside reverse transcriptase inhibitors on coronary heart disease. , 2014, Reviews in cardiovascular medicine.

[148]  R. Johnstone,et al.  New and emerging HDAC inhibitors for cancer treatment. , 2014, The Journal of clinical investigation.

[149]  L. Al-Harthi,et al.  Epigenetic Regulation of HIV-1 Latency in Astrocytes , 2013, Journal of Virology.

[150]  A. Debnath,et al.  Dual-acting stapled peptides target both HIV-1 entry and assembly , 2013, Retrovirology.

[151]  W. Greene,et al.  An Integrated Overview of HIV-1 Latency , 2013, Cell.

[152]  Madeline A. Lancaster,et al.  Cerebral organoids model human brain development and microcephaly , 2013, Nature.

[153]  F. Dequiedt,et al.  CTIP2 is a negative regulator of P-TEFb , 2013, Proceedings of the National Academy of Sciences.

[154]  Alessandro Marcello,et al.  HIV-1 transcription and latency: an update , 2013, Retrovirology.

[155]  E. Verdin,et al.  Reactivation of latent HIV by histone deacetylase inhibitors. , 2013, Trends in microbiology.

[156]  M. Benkirane,et al.  Phosphorylation of SAMHD1 by cyclin A2/CDK1 regulates its restriction activity toward HIV-1. , 2013, Cell reports.

[157]  E. Masliah,et al.  Molecular and pathologic insights from latent HIV-1 infection in the human brain , 2013, Neurology.

[158]  J. Martinez-Picado,et al.  Attacking the HIV Reservoir from the Immune and Viral Perspective , 2013, Current HIV/AIDS Reports.

[159]  A. Rice,et al.  Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+ T Cells , 2012, Journal of Virology.

[160]  F. J. Livesey,et al.  Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks , 2012, Nature Protocols.

[161]  R. Fromentin,et al.  An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription. , 2012, Cell host & microbe.

[162]  F. Bushman,et al.  Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency , 2012, PLoS pathogens.

[163]  T. Chun,et al.  Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy , 2012, Journal of Virology.

[164]  E. V. Bockstaele,et al.  HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes , 2012, Neurobiology of Disease.

[165]  Andrew P. Rice,et al.  Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes , 2011, Journal of Virology.

[166]  C. Van Lint,et al.  LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing , 2011, Nucleic acids research.

[167]  H. Xiong,et al.  HIV-1gp120 Induces Neuronal Apoptosis through Enhancement of 4-Aminopyridine-Senstive Outward K+ Currents , 2011, PloS one.

[168]  J. Bell,et al.  Brain cell reservoirs of latent virus in presymptomatic HIV-infected individuals. , 2011, The American journal of pathology.

[169]  Jonathan Karn,et al.  T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway. , 2011, Journal of molecular biology.

[170]  J. Karn,et al.  Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2 , 2011, Journal of Virology.

[171]  J. Clements,et al.  Eradication of HIV from the brain: reasons for pause. , 2011, AIDS.

[172]  H. Fox,et al.  MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease , 2010, Cell Death and Disease.

[173]  J. Clements,et al.  Simian immunodeficiency virus-infected macaques treated with highly active antiretroviral therapy have reduced central nervous system viral replication and inflammation but persistence of viral DNA. , 2010, The Journal of infectious diseases.

[174]  K. Jeang,et al.  Human cellular restriction factors that target HIV-1 replication , 2009, BMC medicine.

[175]  S. Burma,et al.  Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells , 2009, EMBO reports.

[176]  E. Verdin,et al.  Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation , 2009, PLoS pathogens.

[177]  J. Dai,et al.  Human Immunodeficiency Virus Integrates Directly into Naïve Resting CD4+ T Cells but Enters Naïve Cells Less Efficiently than Memory Cells , 2009, Journal of Virology.

[178]  E. Paskaleva,et al.  BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex. , 2008, Virology.

[179]  D. Greiner,et al.  Creation of “Humanized” Mice to Study Human Immunity , 2008, Current protocols in immunology.

[180]  Dongyang Yu,et al.  Human macrophages support persistent transcription from unintegrated HIV-1 DNA. , 2008, Virology.

[181]  D. Nickle,et al.  Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. , 2008, The Journal of infectious diseases.

[182]  Y. Yen,et al.  Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression* , 2007, Journal of Biological Chemistry.

[183]  F. Dequiedt,et al.  Recruitment of chromatin‐modifying enzymes by CTIP2 promotes HIV‐1 transcriptional silencing , 2007, The EMBO journal.

[184]  A. Knezevich,et al.  Suv39H1 and HP1γ are responsible for chromatin‐mediated HIV‐1 transcriptional silencing and post‐integration latency , 2007, The EMBO journal.

[185]  D. Dormont,et al.  Characterization of human monocyte‐derived microglia‐like cells , 2006, Glia.

[186]  A. Pol.  Viral infections in the developing and mature brain , 2006, Trends in Neurosciences.

[187]  M. Churchill,et al.  Use of laser capture microdissection to detect integrated HIV-1 DNA in macrophages and astrocytes from autopsy brain tissues , 2006, Journal of NeuroVirology.

[188]  J. Clements,et al.  Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model. , 2006, The Journal of infectious diseases.

[189]  M. Pazin,et al.  Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions , 2006, Science.

[190]  Axel Imhof,et al.  Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9 , 2005, Nature chemical biology.

[191]  C. Van Lint,et al.  COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells , 2005, Nucleic acids research.

[192]  A. Brooks,et al.  A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[193]  K. Morris,et al.  Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells , 2004, Science.

[194]  F. Bushman,et al.  RNA interference against retroviruses. , 2004, Virus research.

[195]  T. Rana,et al.  Inhibition of Human Immunodeficiency Virus Type 1 Replication by RNA Interference Directed against Human Transcription Elongation Factor P-TEFb (CDK9/CyclinT1) , 2004, Journal of Virology.

[196]  John J Rossi,et al.  Approaches for the sequence-specific knockdown of mRNA , 2003, Nature Biotechnology.

[197]  D. Aunis,et al.  Regulation of HIV‐1 gene transcription: from lymphocytes to microglial cells , 2003, Journal of leukocyte biology.

[198]  M. Leid,et al.  COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. , 2002, The Biochemical journal.

[199]  Tara L. Kieffer,et al.  Intrinsic Stability of Episomal Circles Formed during Human Immunodeficiency Virus Type 1 Replication , 2002, Journal of Virology.

[200]  M. Leid,et al.  Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors* , 2000, The Journal of Biological Chemistry.

[201]  D. Aunis,et al.  Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells , 2000, Journal of Virology.

[202]  R. Lempicki,et al.  HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[203]  J. Clements,et al.  High Viral Load in the Cerebrospinal Fluid and Brain Correlates with Severity of Simian Immunodeficiency Virus Encephalitis , 1999, Journal of Virology.

[204]  Anthony S. Fauci,et al.  AIDS: Re-emergence of HIV after stopping therapy , 1999, Nature.

[205]  B. Korber,et al.  A new classification for HIV-1 , 1998, Nature.

[206]  D. Aunis,et al.  COUP-TF and Sp1 Interact and Cooperate in the Transcriptional Activation of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Human Microglial Cells* , 1997, The Journal of Biological Chemistry.

[207]  D. Richman,et al.  Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. , 1997, Science.

[208]  E A Emini,et al.  Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. , 1997, The New England journal of medicine.

[209]  Alan S. Perelson,et al.  Decay characteristics of HIV-1-infected compartments during combination therapy , 1997, Nature.

[210]  M. Bina,et al.  Regulation of HIV-1 gene expression by NF-IL6. , 1996, Journal of molecular biology.

[211]  A. Perelson,et al.  HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time , 1996, Science.

[212]  H. Vinters,et al.  High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients , 1990, Nature.

[213]  C. Wiley,et al.  Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[214]  R. Brack-Werner.  Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. , 1999, AIDS.