Therapeutic Efficacy Assessment of Dectomax® (Doramectin) in Sheep and Cattle From Timis County, Romania

Introduction: Gastrointestinal parasitic infestations are one of the major health concerns worldwide; hence, this study aimed to investigate the efficacy of a doramectin-based anti-parasitic drug. Methods: To achieve this goal, we collected fresh faecal samples (50-100 g) from 20 sheep and 20 cattle, which were subsequently examined through coproparasitic methods. Results: Pre-therapeutic coproscopic screening of samples from sheep and cattle led to the identification of digestive strongyles, Eimeria spp., Balantidium coli, Cestodes, and Toxocara spp. The prevalence rates for sheep were 100%, 35%, 35%, 30%, and 15%, respectively, and 80%, 30%, 30%, 10%, and 10% for cattle. Conclusion: The study led to the identification of parasites belonging to three different species: Sporozoa, Nematoda, and Cestoda. None of the investigated helminths proved resistant to Dectomax®, meaning that the average efficacy rate of Dectomax® in sheep and cattle naturally infected with digestive strongyles, Eimeria spp. or Toxocara spp. was 94% and 95%, respectively.

[1]  P. Geldhof,et al.  Anthelmintic resistance and common worm control practices in sheep farms in Flanders, Belgium. , 2020, Veterinary parasitology, regional studies and reports.

[2]  L. Rinaldi.  25 th International Conference of the WAAVP (World Association for the Advancement of Veterinary Parasitology) , 2015 .

[3]  Khayatnouri Mirhadi,et al.  The Effect of Ivermectin Pour-On Administration Against Natural Trichostrongylus colubriformis Infestations and Prevalence Rate of that in Cattle , 2011 .

[4]  S. Indumathy,et al.  Anthelminthic activity of Asta Churna , 2010 .

[5]  M. S. Silva.  Efficacy of moxidectin, ivermectin and doramectin for the control of gastrointestinal nematodes in cattle in the Sertão Paraibano mesoregion. , 2009 .

[6]  F. Borgsteede,et al.  Doramectin and albendazole resistance in sheep in The Netherlands. , 2007, Veterinary parasitology.

[7]  F. Regassa,et al.  Epidemiology of Gastrointestinal Parasites of Ruminants in Western Oromia, Ethiopia , 2006 .

[8]  J. Cabaret,et al.  Faecal egg count reduction test for assessing anthelmintic efficacy: average versus individually based estimations. , 2004, Veterinary parasitology.

[9]  A. Sahin,et al.  The Efficacy of Moxidectin and Doramectin against Gastrointestinal Nematode Infection in Cattle , 2003 .

[10]  D. Keller,et al.  Efficacy of topically administered doramectin against eyeworms, lungworms, and gastrointestinal nematodes of cattle. , 1999, American journal of veterinary research.

[11]  P. Waller.  International approaches to the concept of integrated control of nematode parasites of livestock. , 1999, International journal for parasitology.

[12]  P. Waller.  Nematode parasite control of livestock in the tropics/subtropics: the need for novel approaches. , 1997, International journal for parasitology.

[13]  J. Malone,et al.  World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine) , 1995, Veterinary parasitology.

[14]  T. Watson,et al.  Efficacy of doramectin against experimental infections by some nematode parasites in cattle in New Zealand. , 1995, New Zealand veterinary journal.

[15]  Dwight D. Bowman,et al.  Georgis' Parasitology for Veterinarians , 1995 .

[16]  R. K. Reinecke.  Parasitic control in intensive vs. non-intensive systems--ruminants. , 1994, Veterinary parasitology.

[17]  P. Waller.  Towards sustainable nematode parasite control of livestock. , 1993, Veterinary parasitology.

[18]  P. Waller.  Anthelmintic resistance and the future for roundworm control. , 1987, Veterinary parasitology.

[19]  H. Willis.  A SIMPLE LEVITATION METHOD FOR THE DETECTION OF HOOKWORM OVA , 1921 .