Stereocontrolled solid-phase synthesis of a 90-membered library of indoline-alkaloid-like polycycles from an enantioenriched aminoindoline scaffold.

A library of tricyclic derivatives, similar to indoline alkaloids, has been generated by using a stereocontrolled, conjugate hetero‐Michael approach in both the solution and the solid phase (see scheme; P=protecting group, R=functional group). The mild reaction conditions that lead to the tricyclic derivatives, which contain β‐amino acid functionalities, are highly attractive.

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