Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

[1]  Christopher B. Miller,et al.  BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros , 2008, Nature.

[2]  P. Swanson,et al.  V(D)J Recombinase Binding and Cleavage of Cryptic Recombination Signal Sequences Identified from Lymphoid Malignancies* , 2008, Journal of Biological Chemistry.

[3]  Michael M. Murphy,et al.  Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. , 2008, Blood.

[4]  D. Schatz,et al.  Two levels of protection for the B cell genome during somatic hypermutation , 2008, Nature.

[5]  T. Enver,et al.  Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia , 2008, Science.

[6]  Alberto Martin,et al.  Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AID , 2007, Molecular and Cellular Biology.

[7]  D. Arber,et al.  ''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases. , 2007, The Journal of molecular diagnostics : JMD.

[8]  Nayun Kim,et al.  Transcription-associated mutagenesis in yeast is directly proportional to the level of gene expression and influenced by the direction of DNA replication. , 2007, DNA repair.

[9]  D. Weinstock,et al.  Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70 , 2007, Nature Cell Biology.

[10]  M. Neuberger,et al.  Molecular mechanisms of antibody somatic hypermutation. , 2007, Annual review of biochemistry.

[11]  M. Lieber,et al.  The structure-specific nicking of small heteroduplexes by the RAG complex: implications for lymphoid chromosomal translocations. , 2007, DNA repair.

[12]  F. Papavasiliou,et al.  Regulation of AID expression in the immune response , 2007, The Journal of experimental medicine.

[13]  M. D. Boer,et al.  Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement , 2007, Leukemia.

[14]  Frederick W. Alt,et al.  References and Notes Supporting Online Material Materials and Methods Figs. S1 to S3 Table S1 References Antibody Class Switching Mediated by Yeast Endonuclease–generated Dna Breaks , 2022 .

[15]  K. Bendix,et al.  Multiplex PCR for the detection of BCL-1/IGH and BCL-2/IGH gene rearrangements – clinical validation in a prospective study of blood and bone marrow in 258 patients with or suspected of non-Hodgkin's lymphoma. , 2007, Acta oncologica.

[16]  W. Hofmann,et al.  Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1–transformed acute lymphoblastic leukemia cells , 2007, The Journal of experimental medicine.

[17]  Charles Lee,et al.  The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. , 2006, Blood.

[18]  J. Said,et al.  Association of Ig/BCL6 translocations with germinal center B lymphocytes in human lymphoid tissues: implications for malignant transformation. , 2006, Blood.

[19]  M. Lieber,et al.  Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations. , 2006, DNA repair.

[20]  D. Schatz,et al.  AID and Igh switch region-Myc chromosomal translocations. , 2006, DNA repair.

[21]  W. Klapper,et al.  Chromosomal Translocations Fusing the BCL6 Gene to Different Partner Loci Are Recurrent in Primary Central Nervous System Lymphoma and May Be Associated With Aberrant Somatic Hypermutation or Defective Class Switch Recombination , 2006, Journal of neuropathology and experimental neurology.

[22]  A. Ho,et al.  The bcl-2/IgH rearrangement in a population of 204 healthy individuals: occurrence, age and gender distribution, breakpoints, and detection method validity. , 2006, Leukemia research.

[23]  P. Jordan,et al.  Three‐way translocation involves MLL, MLLT3, and a novel cell cycle control gene, FLJ10374, in the pathogenesis of acute myeloid leukemia with t(9;11;19)(p22;q23;p13.3) , 2006, Genes, chromosomes & cancer.

[24]  M. D. Boer,et al.  The MLL recombinome of acute leukemias , 2006, Leukemia.

[25]  A. Tomkinson,et al.  DNA ligases: structure, reaction mechanism, and function. , 2006, Chemical reviews.

[26]  Yunmei Ma,et al.  Double-Strand Break Formation by the RAG Complex at the Bcl-2 Major Breakpoint Region and at Other Non-B DNA Structures In Vitro , 2005, Molecular and Cellular Biology.

[27]  K. Anderson,et al.  Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia , 2005, Nature Medicine.

[28]  A. W. Harris,et al.  T-cell lymphomas mask slower developing B-lymphoid and myeloid tumours in transgenic mice with broad haemopoietic expression of MYC , 2005, Oncogene.

[29]  R. Pieters,et al.  Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells. , 2005, Cancer research.

[30]  A. Borkhardt,et al.  Level of MYC overexpression in pediatric Burkitt's lymphoma is strongly dependent on genomic breakpoint location within the MYC locus , 2004, Genes, chromosomes & cancer.

[31]  U. Storb,et al.  Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Nussenzweig,et al.  AID Is Required for c-myc/IgH Chromosome Translocations In Vivo , 2004, Cell.

[33]  M. Lieber,et al.  A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex , 2004, Nature.

[34]  M. Lieber,et al.  DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine* , 2004, Journal of Biological Chemistry.

[35]  T. Imanishi‐Kari,et al.  T cell-independent somatic hypermutation in murine B cells with an immature phenotype. , 2004, Immunity.

[36]  E. Zucca,et al.  Molecular basis of mantle cell lymphoma , 2004, British journal of haematology.

[37]  M. Greaves,et al.  Origins of chromosome translocations in childhood leukaemia , 2003, Nature Reviews Cancer.

[38]  M. Boccadoro,et al.  Recurrence of Bcl-2/IgH polymerase chain reaction positivity following a prolonged molecular remission can be unrelated to the original follicular lymphoma clone. , 2003, Experimental hematology.

[39]  Francisco Vega,et al.  Chromosomal translocations involved in non-Hodgkin lymphomas. , 2003, Archives of pathology & laboratory medicine.

[40]  D. Barnes,et al.  Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas , 2003, Oncogene.

[41]  E. Jaffe Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissues , 2003 .

[42]  M. Goodman,et al.  Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation , 2003, Nature.

[43]  N. Kakazu,et al.  Constitutive Expression of AID Leads to Tumorigenesis , 2003, The Journal of experimental medicine.

[44]  M. Loh,et al.  Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California , 2003, Genes, chromosomes & cancer.

[45]  A. Borkhardt,et al.  Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy‐related AML after treatment without etoposides , 2003, Genes, chromosomes & cancer.

[46]  M. Goodman,et al.  Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[47]  F. Behm,et al.  Characterization of the MLL partner gene AF15q14 involved in t(11;15)(q23;q14) , 2003, Oncogene.

[48]  T. Bestor Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis , 2003, Annals of the New York Academy of Sciences.

[49]  J. Wiemels,et al.  TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. , 2003, Leukemia research.

[50]  D. Wechsler,et al.  A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein , 2003, Genes, chromosomes & cancer.

[51]  Kaoru Inoue,et al.  Prevalent Involvement of Illegitimate V(D)J Recombination in Chromosome 9p21 Deletions in Lymphoid Leukemia* , 2002, The Journal of Biological Chemistry.

[52]  W. Edelmann,et al.  Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Xiaomei Ma,et al.  Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  A. Norton,et al.  JH probe real‐time quantitative polymerase chain reaction assay for Bcl‐2/IgH rearrangements , 2002, British journal of haematology.

[55]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[56]  F. Alt,et al.  The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.

[57]  P. Nowell,et al.  Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[58]  W. J. Kent,et al.  BLAT--the BLAST-like alignment tool. , 2002, Genome research.

[59]  M. Kurrer,et al.  High frequency of t(14;18)-translocation breakpoints outside of major breakpoint and minor cluster regions in follicular lymphomas: improved polymerase chain reaction protocols for their detection. , 2002, The American journal of pathology.

[60]  J. Rowley,et al.  Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[61]  M. Lieber,et al.  The Cleavage Efficiency of the Human Immunoglobulin Heavy Chain VH Elements by the RAG Complex , 2002, The Journal of Biological Chemistry.

[62]  D. Schatz V(D)J recombination , 2002, Immunological Reviews.

[63]  B. Nadel,et al.  V(D)J-mediated Translocations in Lymphoid Neoplasms , 2002, The Journal of experimental medicine.

[64]  P. Vyas,et al.  Pathology and genetics: Tumours of haematopoietic and lymphoid tissues , 2001 .

[65]  Vasco M. Barreto,et al.  Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice , 2001, European journal of immunology.

[66]  M. Segal,et al.  Molecular characterization of genomic AML1-ETO fusions in childhood leukemia , 2001, Leukemia.

[67]  R. Siebert,et al.  Detection of translocations affecting the BCL6 locus in B cell non-Hodgkin's lymphoma by interphase fluorescence in situ hybridization , 2001, Leukemia.

[68]  M. Lieber,et al.  Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints* , 2001, The Journal of Biological Chemistry.

[69]  I. Soubeyran,et al.  A 1-Kb Bcl-2-PCR Fragment Detection in a Patient With Follicular Lymphoma and Development of a New Diagnostic PCR Method , 2001, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[70]  O. Haas,et al.  Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL , 2001, Oncogene.

[71]  M. Melbye,et al.  Characterization of t(12;21) breakpoint junctions in acute lymphoblastic leukemia , 2001, Leukemia.

[72]  B. Nadel,et al.  Templated nucleotide addition and immunoglobulin JH-gene utilization in t(11;14) junctions: implications for the mechanism of translocation and the origin of mantle cell lymphoma. , 2001, Cancer research.

[73]  T. Lister,et al.  Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[74]  M. Greaves,et al.  Microclustering of TEL‐AML1 translocation breakpoints in childhood acute lymphoblastic leukemia , 2000, Genes, chromosomes & cancer.

[75]  L. Urban,et al.  Diagnostic value of the detection of t(14;18) chromosome translocation in malignant hematological and immunopathological diseases using polymerase chain reaction. , 2000, Acta medica Okayama.

[76]  G. Deléage,et al.  AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14) , 2000, Oncogene.

[77]  B. Nadel,et al.  Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocation. , 2000, Blood.

[78]  M. Seto,et al.  Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5′-RACE and LA – PCR analyses of biopsy samples , 1999, Oncogene.

[79]  A. Villa,et al.  The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination. , 1999, Molecular cell.

[80]  I. Soubeyran,et al.  Evolution of BCL-2/IgH hybrid gene RNA expression during treatment of T(14;18)-bearing follicular lymphomas , 1999, British Journal of Cancer.

[81]  M. Greaves,et al.  Structure and possible mechanisms of TEL-AML1 gene fusions in childhood acute lymphoblastic leukemia. , 1999, Cancer research.

[82]  R. Marschalek,et al.  Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research. , 1999, Cancer research.

[83]  U. Kees,et al.  Molecular characterization of a complex chromosomal translocation breakpoint t(10;14) including the HOX11 oncogene locus , 1999, Leukemia.

[84]  K. Stamatopoulos,et al.  Molecular analysis of bcl‐1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation , 1999, British journal of haematology.

[85]  J. SantaLucia,et al.  Nearest-neighbor thermodynamics and NMR of DNA sequences with internal A.A, C.C, G.G, and T.T mismatches. , 1999, Biochemistry.

[86]  R. Marschalek,et al.  Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation , 1998, Oncogene.

[87]  G. Delsol,et al.  Detection of t(14;18) carrying cells in bone marrow and peripheral blood from patients affected by non-lymphoid diseases. , 1998, Molecular pathology : MP.

[88]  M. Tiemann,et al.  Structure of Bcl-1 and IgH-CDR3 rearrangements as clonal markers in mantle cell lymphomas , 1998, Leukemia.

[89]  M. Qumsiyeh,et al.  No Requirement for V(D)J Recombination in p53-Deficient Thymic Lymphoma , 1998, Molecular and Cellular Biology.

[90]  E. Rappaport,et al.  t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[91]  S. Sowerby,et al.  The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia. , 1998, Human molecular genetics.

[92]  D. Leonard,et al.  Novel bcl‐2 Breakpoints in Patients with Follicular Lymphoma , 1998, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[93]  K. Saito,et al.  Two Burkitt-type lymphoma/leukemia-derived cell lines presenting 3q27 translocations and immunoglobulin/BCL6 chimeric transcripts. , 1997, Leukemia.

[94]  T. Lindahl,et al.  XRCC1 protein interacts with one of two distinct forms of DNA ligase III. , 1997, Biochemistry.

[95]  W. Pugh,et al.  The Application of Fluorescence‐Based PCR and PCR‐SSCP to Monitor the Clonal Relationship of Cells Bearing the t(14;18)(q32;q21) in Sequential Biopsy Specimens from Patients with Follicle Center Cell Lymphoma , 1997, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[96]  J. Buckley,et al.  The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline. , 1996, Journal of molecular biology.

[97]  R. Chaganti,et al.  Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. , 1995, The EMBO journal.

[98]  M. Potter,et al.  Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations. , 1995, Cancer research.

[99]  H. Griesser,et al.  MSH2 deficient mice are viable and susceptible to lymphoid tumours , 1995, Nature Genetics.

[100]  R. Beart,et al.  Base excision repair of U:G mismatches at a mutational hotspot in the p53 gene is more efficient than base excision repair of T:G mismatches in extracts of human colon tumors. , 1995, Cancer research.

[101]  P. Ye,et al.  Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. , 1995, Cancer research.

[102]  R. Marschalek,et al.  Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;ll) , 1995, British journal of haematology.

[103]  D. Jong,et al.  Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals. , 1995, Blood.

[104]  J. Goldman,et al.  Characterization of genomic BCR‐ABL breakpoints in chronic myeloid leukaemia by PCR , 1995, British journal of haematology.

[105]  W. Hiddemann,et al.  Low incidence of mbr bcl‐2/JH fusion genes in Hodgkin's disease , 1995, The Journal of pathology.

[106]  R. Braylan,et al.  CD5-expressing B-cell non-Hodgkin's lymphomas with bcl-1 gene rearrangement have a relatively homogeneous immunophenotype and are associated with an overall poor prognosis. , 1995, Blood.

[107]  D. Shibata,et al.  BCL2 translocation frequency rises with age in humans. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[108]  H. Lovec,et al.  Cyclin D1/bcl‐1 cooperates with myc genes in the generation of B‐cell lymphoma in transgenic mice. , 1994, The EMBO journal.

[109]  F. Berger,et al.  Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas. , 1994, Blood.

[110]  M. Schlissel,et al.  Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated. , 1993, Genes & development.

[111]  P. Koduru,et al.  Molecular characterization of a variant Ph1 translocation t(9;22;11) (q34;q11;q13) in chronic myelogenous leukemia (CML) reveals the translocation of the 3'-part of BCR gene to the chromosome band 11q13. , 1993, Oncogene.

[112]  C. Bartram,et al.  Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood. , 1993, Blood.

[113]  R. Berger,et al.  Characterization of translocation t(1;14)(p32;q11) in a T and in a B acute leukemia. , 1993, Leukemia.

[114]  C. Croce,et al.  Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. , 1993, Cancer research.

[115]  M. Williams,et al.  Chromosome t(11;14)(q13;q32) breakpoints in centrocytic lymphoma are highly localized at the bcl-1 major translocation cluster. , 1993, Leukemia.

[116]  H. Tilly,et al.  LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas , 1993, Nature Genetics.

[117]  W. Sterry,et al.  SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. , 1993, Leukemia.

[118]  R. Espinosa,et al.  Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[119]  M. Amylon,et al.  Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study. , 1993, Blood.

[120]  R. Brunning,et al.  Duplication of small segments within the major breakpoint cluster region in chronic myelogenous leukemia. , 1993, Blood.

[121]  S. Raimondi,et al.  Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia , 1992, The Journal of experimental medicine.

[122]  R. Berger,et al.  A third tal-1 promoter is specifically used in human T cell leukemias , 1992, The Journal of experimental medicine.

[123]  J. Sklar,et al.  Detection of the t(14;18) at similar frequencies in hyperplastic lymphoid tissues from American and Japanese patients. , 1992, The American journal of pathology.

[124]  Adrian Bird,et al.  The essentials of DNA methylation , 1992, Cell.

[125]  A. Polack,et al.  Two antisense promoters in the immunoglobulin mu-switch region drive expression of c-myc in the Burkitt's lymphoma cell line BL67. , 1992, Oncogene.

[126]  A. Zelenetz,et al.  BCL2 oncogene translocation is mediated by a chi-like consensus , 1992, The Journal of experimental medicine.

[127]  P. Elvin,et al.  Amplification and sequencing of genomic breakpoints located within the M-bcr region by Vectorette-mediated polymerase chain reaction. , 1992, Leukemia.

[128]  A. Carroll,et al.  The translocation (1;14)(p34;q11) in human t‐cell leukemia: Chromosome breakage 25 kilobase pairs downstream of the tal1 protooncogene , 1992, Genes, chromosomes & cancer.

[129]  H. Sather,et al.  Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. , 1992, Blood.

[130]  J. Rowley,et al.  A complex genetic rearrangement in a t(10;14)(q24;q11) associated with T‐cell acute lymphoblastic leukemia , 1992, Genes, chromosomes & cancer.

[131]  D. de Jong,et al.  Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasia. , 1991, Oncogene.

[132]  D. Withers,et al.  Cloning of the t(11;14)(q13;q32) translocation breakpoints from two human leukemia cell lines. , 1991, Leukemia.

[133]  T. Lister,et al.  Detection of additional JH/BCL2 translocations in follicular lymphoma. , 1991, Leukemia.

[134]  Ó. Jónsson,et al.  Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia. , 1991, The Journal of clinical investigation.

[135]  I. Kirsch,et al.  Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. , 1990, Science.

[136]  S. Raimondi,et al.  Molecular characterization of the t(10;14) translocation breakpoints in T‐cell acute lymphoblastic leukemia: Further evidence for illegitimate physiological recombination , 1990, Genes, chromosomes & cancer.

[137]  A. Bird,et al.  High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines , 1990, Cell.

[138]  S. Korsmeyer,et al.  The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the delta T-cell receptor with TCL3, a conserved and activated locus at 10q24. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[139]  T. Kunkel,et al.  A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. , 1990, Biochemistry.

[140]  R. Berger,et al.  Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T‐cell leukemias , 1990, Genes, chromosomes & cancer.

[141]  M. Siciliano,et al.  The chromosome translocation (11;14)(p13;q11) associated with T-cell acute lymphocytic leukemia: an 11p13 breakpoint cluster region. , 1989, Blood.

[142]  P. Nowell,et al.  Clustering of breakpoints on chromosome 10 in acute T-cell leukemias with the t(10;14) chromosome translocation. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[143]  M. Cleary,et al.  Detection of chromosomal translocation t(14;18) within the minor cluster region of bcl-2 by polymerase chain reaction and direct genomic sequencing of the enzymatically amplified DNA in follicular lymphomas. , 1989, Blood.

[144]  S. Korsmeyer,et al.  The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein , 1989, Molecular and cellular biology.

[145]  S. Korsmeyer,et al.  bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation , 1989, Cell.

[146]  T. Waldmann,et al.  Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[147]  Y. Tsujimoto,et al.  The reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanism. , 1988, Oncogene.

[148]  S. Korsmeyer,et al.  Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[149]  P. Leder,et al.  A translocated human c-myc oncogene is altered in a conserved coding sequence. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[150]  C. Croce,et al.  The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. , 1985, Science.

[151]  S. Korsmeyer,et al.  Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18 , 1985, Cell.

[152]  Kees Stam,et al.  Structural organization of the bcr gene and its role in the Ph′ translocation , 1985, Nature.

[153]  P. Nowell,et al.  Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation , 1985, Nature.

[154]  C. Croce,et al.  Cloning and sequencing of a c-myc oncogene in a Burkitt's lymphoma cell line that is translocated to a germ line alpha switch region , 1985, Molecular and cellular biology.

[155]  W. S. Hayward,et al.  Activation of a translocated c-myc gene: role of structural alterations in the upstream region. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[156]  W. S. Hayward,et al.  Activation of the c-myc gene by translocation: a model for translational control. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[157]  M. Wabl,et al.  Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement , 1983, Nature.

[158]  P. Leder,et al.  The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphoma , 1983, Cell.

[159]  F. Alt,et al.  Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line , 1982, Nature.

[160]  S. Tonegawa,et al.  Somatic generation of antibody diversity. , 1976, Nature.

[161]  W. Chan,et al.  Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event. , 2008, American journal of clinical pathology.

[162]  G. Xu,et al.  Cytosine methylation and DNA repair. , 2006, Current topics in microbiology and immunology.

[163]  M. Schlissel,et al.  Leukemia and lymphoma: a cost of doing business for adaptive immunity. , 2006, Genes & development.

[164]  G. Pfeifer Mutagenesis at methylated CpG sequences. , 2006, Current topics in microbiology and immunology.

[165]  C. Friedberg Errol,et al.  DNA Repair and Mutagenesis, Second Edition , 2006 .

[166]  E. Friedberg,et al.  DNA Repair and Mutagenesis , 2006 .

[167]  F. Alt,et al.  Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. , 2005, Advances in immunology.

[168]  Daiya Takai,et al.  The CpG Island Searcher: A new WWW resource , 2003, Silico Biol..

[169]  W. Edelmann,et al.  Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation. , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[170]  B. Nadel,et al.  Alternative end-joining in follicular lymphomas’ t(14;18) translocation , 2002, Leukemia.

[171]  Tactggtat Agcctagatgtgtttaga,et al.  J-mediated Translocations in Lymphoid Neoplasms : A Functional Assessment of Genomic Instability by Cryptic Sites , 2001 .

[172]  M. Dyer,et al.  Rapid molecular cloning of rearrangements of the IGHJ locus using long-distance inverse polymerase chain reaction. , 1997, Blood.

[173]  R. Warnke,et al.  Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma. , 1997, Annals of oncology : official journal of the European Society for Medical Oncology.

[174]  B. Roe,et al.  Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia. , 1997, Genes, chromosomes & cancer.

[175]  E. Freireich,et al.  Joining of recombination signals on the der 14q- chromosome in T-cell acute leukemia with t(10;14) chromosome translocation. , 1994, Cancer research.

[176]  J. Melo,et al.  Chromosome abnormalities at 11q13 in B cell tumours , 1988 .

[177]  E. Friedberg DNA Excision Repair Pathways , 2022 .