Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study

BACKGROUND Whether local exposure to major roadways adversely affects lung-function growth during the period of rapid lung development that takes place between 10 and 18 years of age is unknown. This study investigated the association between residential exposure to traffic and 8-year lung-function growth. METHODS In this prospective study, 3677 children (mean age 10 years [SD 0.44]) participated from 12 southern California communities that represent a wide range in regional air quality. Children were followed up for 8 years, with yearly lung-function measurements recorded. For each child, we identified several indicators of residential exposure to traffic from large roads. Regression analysis was used to establish whether 8-year growth in lung function was associated with local traffic exposure, and whether local traffic effects were independent of regional air quality. FINDINGS Children who lived within 500 m of a freeway (motorway) had substantial deficits in 8-year growth of forced expiratory volume in 1 s (FEV(1), -81 mL, p=0.01 [95% CI -143 to -18]) and maximum midexpiratory flow rate (MMEF, -127 mL/s, p=0.03 [-243 to -11), compared with children who lived at least 1500 m from a freeway. Joint models showed that both local exposure to freeways and regional air pollution had detrimental, and independent, effects on lung-function growth. Pronounced deficits in attained lung function at age 18 years were recorded for those living within 500 m of a freeway, with mean percent-predicted 97.0% for FEV1 (p=0.013, relative to >1500 m [95% CI 94.6-99.4]) and 93.4% for MMEF (p=0.006 [95% CI 89.1-97.7]). INTERPRETATION Local exposure to traffic on a freeway has adverse effects on children's lung development, which are independent of regional air quality, and which could result in important deficits in attained lung function in later life.

[1]  R K Griffiths,et al.  Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. , 1994, Archives of environmental health.

[2]  M. Segal,et al.  Association between lifetime ambient ozone exposure and pulmonary function in college freshmen--results of a pilot study. , 1997, Environmental research.

[3]  U Keil,et al.  Inner city air pollution and respiratory health and atopy in children. , 1999, The European respiratory journal.

[4]  D. Dockery,et al.  Pulmonary function growth velocity in children 6 to 18 years of age. , 1993, The American review of respiratory disease.

[5]  A. Hodgson,et al.  Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study. , 2004, American journal of respiratory and critical care medicine.

[6]  Lesley Rushton,et al.  Carbon in airway macrophages and lung function in children , 2006, European Respiratory Review.

[7]  Atif J. Khan,et al.  Atmospheric transport of elemental carbon , 2006 .

[8]  Duanping Liao,et al.  Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. , 2003, American journal of epidemiology.

[9]  W S Linn,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. , 1999, American journal of respiratory and critical care medicine.

[10]  M. Wjst,et al.  Road traffic and adverse effects on respiratory health in children. , 1993, BMJ.

[11]  Ira B. Tager,et al.  Chronic Exposure to Ambient Ozone and Lung Function in Young Adults , 2005, Epidemiology.

[12]  Simon Kingham,et al.  Traffic-related differences in outdoor and indoor concentrations of particles and volatile organic compounds in Amsterdam , 2000 .

[13]  W James Gauderman,et al.  Childhood Asthma and Exposure to Traffic and Nitrogen Dioxide , 2005, Epidemiology.

[14]  M Chiron,et al.  Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study , 2003, Journal of epidemiology and community health.

[15]  R. Delfino,et al.  Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. , 2001, Environmental health perspectives.

[16]  J D Spengler,et al.  Health effects of acid aerosols on North American children: pulmonary function. , 1996, Environmental health perspectives.

[17]  Edward B Rappaport,et al.  Association between air pollution and lung function growth in southern California children: results from a second cohort. , 2002, American journal of respiratory and critical care medicine.

[18]  W. Jędrychowski,et al.  The adverse effect of low levels of ambient air pollutants on lung function growth in preadolescent children. , 1999, Environmental health perspectives.

[19]  A. Siegelaub,et al.  Lung function and risk of myocardial infarction and sudden cardiac death. , 1976, The New England journal of medicine.

[20]  Bert Brunekreef,et al.  Air pollution from traffic in city districts near major motorways. , 1998 .

[21]  Rebecca Bascom,et al.  Health effects of outdoor air pollution , 1996 .

[22]  K. Berhane,et al.  Association between air pollution and lung function growth in southern California children. , 2000, American journal of respiratory and critical care medicine.

[23]  Bert Brunekreef,et al.  Air Pollution from Truck Traffic and Lung Function in Children Living near Motorways , 1997, Epidemiology.

[24]  V M Hawthorne,et al.  Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study , 1996, BMJ.

[25]  W Winkelstein,et al.  Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study. , 2000, Chest.

[26]  Yifang Zhu,et al.  Comparison of daytime and nighttime concentration profiles and size distributions of ultrafine particles near a major highway. , 2006, Environmental science & technology.

[27]  Bert Brunekreef,et al.  Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. , 2002, American journal of respiratory and critical care medicine.

[28]  Bert Brunekreef,et al.  Estimating Long-Term Average Particulate Air Pollution Concentrations: Application of Traffic Indicators and Geographic Information Systems , 2003, Epidemiology.

[29]  Clifford Qualls,et al.  Characterization of a spatial gradient of nitrogen dioxide across a United States-Mexico border city during winter. , 2005, The Science of the total environment.

[30]  J D Spengler,et al.  Effects of inhalable particles on respiratory health of children. , 1989, The American review of respiratory disease.

[31]  U. Krämer,et al.  The Influence of Large-Scale Airborne Particle Decline and Traffic-Related Exposure on Children’s Lung Function , 2005, Environmental health perspectives.

[32]  S. Weiland,et al.  Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children , 2003, European Respiratory Journal.

[33]  Yifang Zhu,et al.  Concentration and Size Distribution of Ultrafine Particles Near a Major Highway , 2002, Journal of the Air & Waste Management Association.

[34]  D. Dockery,et al.  Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children. , 1986, The American review of respiratory disease.

[35]  J. Schauer,et al.  The Distribution of Particle-Phase Organic Compounds in the Atmosphere and Their Use for Source Apportionment during the Southern California Children’s Health Study , 2003, Journal of the Air & Waste Management Association.

[36]  André Nel,et al.  ATMOSPHERE: Enhanced: Air Pollution-Related Illness: Effects of Particles , 2005 .

[37]  P. E. Benson.  CALINE4 - A DISPERSION MODEL FOR PREDICTING AIR POLLUTANT CONCENTRATIONS NEAR ROADWAYS. FINAL REPORT , 1984 .

[38]  R Urbanek,et al.  Lung function growth and ambient ozone: a three-year population study in school children. , 1999, American journal of respiratory and critical care medicine.

[39]  J. Spengler,et al.  Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren , 2002, European Respiratory Journal.

[40]  Duncan C. Thomas,et al.  Statistical Issues in Studies of the Long-Term Effects of Air Pollution: The Southern California Children’s Health Study , 2004 .

[41]  B. Brunekreef,et al.  The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. , 2003, Environmental health perspectives.

[42]  David M Stieb,et al.  Ambient nitrogen dioxide and distance from a major highway. , 2003, The Science of the total environment.

[43]  Michael Lipsett,et al.  Title: Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study Authors and Affiliations , 2004 .

[44]  B. Brunekreef,et al.  Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. , 1997, Environmental research.

[45]  S J London,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. , 1999, American journal of respiratory and critical care medicine.

[46]  Mark S Goldberg,et al.  Assessing Spatial Variability of Ambient Nitrogen Dioxide in Montréal, Canada, with a Land-Use Regression Model , 2005, Journal of the Air & Waste Management Association.

[47]  R. Hubbard,et al.  Living near a main road and the risk of wheezing illness in children. , 2001, American journal of respiratory and critical care medicine.

[48]  Kiros Berhane,et al.  Traffic, Susceptibility, and Childhood Asthma , 2006, Environmental health perspectives.

[49]  W. Kannel,et al.  PULMONARY FUNCTION: RELATION TO AGING, CIGARETTE HABIT, AND MORTALITY , 1976 .

[50]  K. Berhane,et al.  The effect of air pollution on lung development from 10 to 18 years of age. , 2004, The New England journal of medicine.

[51]  R. Hubbard,et al.  Local road traffic activity and the prevalence, severity, and persistence of wheeze in school children: combined cross sectional and longitudinal study , 2000, Occupational and environmental medicine.

[52]  J. Schwartz,et al.  Lung function and chronic exposure to air pollution: a cross-sectional analysis of NHANES II. , 1989, Environmental research.

[53]  W. Kannel,et al.  Vital capacity as a predictor of cardiovascular disease: the Framingham study. , 1983, American heart journal.

[54]  Andre E Nel,et al.  Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. , 2003, Clinical immunology.

[55]  A. James,et al.  Lung function, respiratory symptoms, and mortality: results from the Busselton Health Study. , 1999, Annals of epidemiology.