Four-octyl itaconate activates Keap1-Nrf2 signaling to protect neuronal cells from hydrogen peroxide

[1]  Hai-yan Liu,et al.  Keratinocyte growth factor protects endometrial cells from oxygen glucose deprivation/re-oxygenation via activating Nrf2 signaling. , 2018, Biochemical and biophysical research communications.

[2]  Edward T Chouchani,et al.  Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 , 2018, Nature.

[3]  Maxim N. Artyomov,et al.  Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis , 2018, Nature.

[4]  Hua Liu,et al.  AntagomiR-613 protects neuronal cells from oxygen glucose deprivation/re-oxygenation via increasing SphK2 expression. , 2017, Biochemical and biophysical research communications.

[5]  Xiaofeng Li,et al.  MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV , 2017, Oncotarget.

[6]  Byung-Hyun Park,et al.  Butein induction of HO‐1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high‐fat diet induced adipose hypertrophy in mice , 2017, European journal of pharmacology.

[7]  A. I. Rojo,et al.  Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases , 2017, Redox biology.

[8]  J. Coombes,et al.  Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality? , 2016, Oxidative medicine and cellular longevity.

[9]  Takafumi Suzuki,et al.  Molecular basis of the Keap1-Nrf2 system. , 2015, Free radical biology & medicine.

[10]  C. Sanderson,et al.  Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways , 2015, Biochemical Society transactions.

[11]  R. Deighton,et al.  Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 , 2015, Nature Communications.

[12]  L. Benowitz,et al.  NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. , 2015, The Journal of clinical investigation.

[13]  Qiong Wang,et al.  EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages. , 2015, Biochemical and biophysical research communications.

[14]  Zhenlong Xin,et al.  An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. , 2015, Cytokine & growth factor reviews.

[15]  H. Ohta,et al.  Cytoprotective effects of 12-oxo phytodienoic acid, a plant-derived oxylipin jasmonate, on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells. , 2014, Biochimica et biophysica acta.

[16]  H. Okazawa,et al.  Brain imaging for oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. , 2014, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....

[17]  Jin Yao,et al.  Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling. , 2014, Free radical biology & medicine.

[18]  A. Papavassiliou,et al.  Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease , 2014, NeuroMolecular Medicine.

[19]  M. Tanabe.  Cytoprotective effects of 12-oxo phytodienoic acid, a plant-derived oxylipin jasmonate, on oxidative stress-induced toxicity in human neuroblastoma SH-SY5Y cells , 2014 .

[20]  Chen Li,et al.  Oxygen Glucose Deprivation (OGD)/Re-Oxygenation-Induced In Vitro Neuronal Cell Death Involves Mitochondrial Cyclophilin-D/P53 Signaling Axis , 2013, Neurochemical Research.

[21]  P. Picone,et al.  Are oxidative stress and mitochondrial dysfunction the key players in the neurodegenerative diseases? , 2012, Free radical research.

[22]  Y. Pi,et al.  Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: Evidence from a meta-analysis , 2012, Journal of the Neurological Sciences.

[23]  Sarah Crunkhorn.  Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress , 2012, Nature Reviews Drug Discovery.

[24]  Xin Yang,et al.  NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population , 2011, Journal of the Neurological Sciences.

[25]  R. Hui,et al.  No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population. , 2011, Atherosclerosis.

[26]  M. McMahon,et al.  Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals , 2010, Proceedings of the National Academy of Sciences.

[27]  John H. Zhang,et al.  Sulforaphane protects brains against hypoxic–ischemic injury through induction of Nrf2-dependent phase 2 enzyme , 2010, Brain Research.

[28]  Melvin E Andersen,et al.  A systems biology perspective on Nrf2-mediated antioxidant response. , 2010, Toxicology and applied pharmacology.

[29]  Baoshan Xu,et al.  Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells , 2010, Laboratory Investigation.

[30]  C. Allen,et al.  Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke , 2009, International journal of stroke : official journal of the International Stroke Society.

[31]  Yuyuan Han,et al.  Gαi1 and Gαi3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway , 2009, Science Signaling.

[32]  S. Kim,et al.  Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. , 2008, Toxicology.

[33]  Robert A. Smith,et al.  Oxidative stress in neurodegeneration and available means of protection. , 2008, Frontiers in bioscience : a journal and virtual library.

[34]  S. Biswal,et al.  Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury , 2007, Neuroscience.

[35]  Yang Sun,et al.  Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. , 2007, European journal of pharmacology.

[36]  C. McMurray,et al.  Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases , 2007, Neuroscience.

[37]  W. Plunkett,et al.  H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation , 2007, Molecular Cancer Therapeutics.

[38]  T. Murphy,et al.  A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia In Vivo , 2005, The Journal of Neuroscience.

[39]  J. Milbrandt,et al.  Ninjurin2, a Novel Homophilic Adhesion Molecule, Is Expressed in Mature Sensory and Enteric Neurons and Promotes Neurite Outgrowth , 2000, The Journal of Neuroscience.