Fibrosing Cardiomyopathy within a Population of Managed Primates at a Single Zoological Facility 2000 - 2015

Gross and histopathological review of 74 cases of primate mortality from a single zoological facility from January 2000-December 2015 revealed that the cause of death (COD) in approximately 27% of the cases was cardiovascular disease (CVD). Among the most common CVD diagnoses were fibrosing cardiomyopathy (FCM). Fibrosing cardiomyopathy has been well documented in the great ape species but only on occasion in other primate species. Cardiomyopathy was diagnosed in 11 genera of primates within this col-lection during the study period including chimpanzees (Pan troglodytes) and Bornean orangutans (Pongo pygmaeus). Cardiac fibrosis as a histological finding was significant in 14/20 (70%) of the cardiovascular related deaths with 10 of them (71.4%) also having significant renal lesions. Six of seven cases with renal disease as the COD had cardiac fibrosis (85.7%). Significant histopathological lesions, typically chronic nephritis or glomerulonephritis were noted in 37/74 (50%) of all the cases even if the renal lesions were not implicated as COD.

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