Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise

[1]  Alexander van Oudenaarden,et al.  Variability in gene expression underlies incomplete penetrance , 2009, Nature.

[2]  Young-Joon Kim,et al.  Intrinsic variability of gene expression encoded in nucleosome positioning sequences , 2009, Nature Genetics.

[3]  J. A. Halliday,et al.  Transcriptional Infidelity Promotes Heritable Phenotypic Change in a Bistable Gene Network , 2009, PLoS biology.

[4]  T. Bruxner,et al.  A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development , 2008, Genome Biology.

[5]  C. Sandi,et al.  KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress , 2008, Neuron.

[6]  E. O’Shea,et al.  Chromatin decouples promoter threshold from dynamic range , 2008, Nature.

[7]  G. Kay,et al.  SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation , 2008, Nature Genetics.

[8]  S. Santos,et al.  Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism , 2008, Diabetes.

[9]  J. Opitz,et al.  Obesity: Genetic, molecular, and environmental aspects , 2007, American journal of medical genetics. Part A.

[10]  T. Mikkelsen,et al.  Genome-wide maps of chromatin state in pluripotent and lineage-committed cells , 2007, Nature.

[11]  H. Scott,et al.  Modifiers of epigenetic reprogramming show paternal effects in the mouse , 2007, Nature Genetics.

[12]  Farren J. Isaacs,et al.  Phenotypic consequences of promoter-mediated transcriptional noise. , 2006, Molecular cell.

[13]  T. Clark,et al.  Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited , 2006, Mammalian Genome.

[14]  T. Bruxner,et al.  An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  K. Mather,et al.  Heritable variation in a long inbred line of drosophila , 1955, Genetica.

[16]  J. Raser,et al.  Control of Stochasticity in Eukaryotic Gene Expression , 2004, Science.

[17]  A. Skoultchi,et al.  The ISWI ATPase Snf2h is required for early mouse development , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Mads Kærn,et al.  Noise in eukaryotic gene expression , 2003, Nature.

[19]  D. O’Carroll,et al.  Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression , 2002, The EMBO journal.

[20]  G. Maul,et al.  SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. , 2002, Genes & development.

[21]  Karl Mechtler,et al.  Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability , 2001, Cell.

[22]  J. Friedman,et al.  Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. , 2001, Genes & development.

[23]  P. Chambon,et al.  Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. , 2000, Development.

[24]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[25]  L Young,et al.  The Jackson Laboratory , 1998, Molecular medicine.

[26]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[27]  K. Gärtner,et al.  A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals? , 1990, Laboratory animals.

[28]  A. Griffiths Introduction to Genetic Analysis , 1976 .

[29]  D. Falconer The genetics of litter size in mice. , 1960, Journal of cellular and comparative physiology.

[30]  DONALD MICHIE,et al.  Variance Control in the Animal House , 1958, Nature.

[31]  C. Waddington Canalization of Development and the Inheritance of Acquired Characters , 1942, Nature.