论文信息 - Kinetics studies on triacontanyl palmitate: a urease inhibitor

Kinetics studies on triacontanyl palmitate: a urease inhibitor

The mechanism of inhibition of jack bean and Bacillus pasteurii ureases was investigated by triacontanyl palmitate (1) which is a long-chain fatty ester and has been isolated from Symplocos racemosa Roxb. Lineweaver–Burk, Dixon plots, and their secondary replots showed that 1 is a non-competitive inhibitor of these enzymes. Ki values were found to be 60.03 ± 1.72 and 88.23 ± 0.31 µM against jack bean and B. pasteurii ureases, respectively. †Dedicated to the memory of Dr Mohammad Hussain Panjwani (1940–1992), a renowned philanthropist and scholar.

M. Lodhi | M. Choudhary | V. Ahmad | M. Abbasi

[1] U. Farooq,et al. Lipoxygenase inhibiting ethyl substituted glycoside from Symplocos racemosa , 2005, Natural product research.

[2] V. Kalia,et al. Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology. , 2004, Journal of ethnopharmacology.

[3] R. Supino,et al. Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles. , 2004, Biochemical and biophysical research communications.

[4] M. Lodhi,et al. Biscoumarin: new class of urease inhibitors; economical synthesis and activity. , 2004, Bioorganic & medicinal chemistry.

[5] Atta-ur- Rahman,et al. Chemistry and mechanism of urease inhibition. , 2002, Current medicinal chemistry.

[6] R. Hausinger,et al. Copyright � 1995, American Society for Microbiology Molecular Biology of Microbial Ureases , 1995 .

[7] J. Polacco,et al. Essential Role of Urease in Germination of Nitrogen-Limited Arabidopsis thaliana Seeds , 1995, Plant physiology.

[8] E. Bayerdörffer,et al. The role of antibiotics in Campylobacter pylori associated peptic ulcer disease. , 1988, Scandinavian journal of gastroenterology. Supplement.