Genetics of COPO

The prevalence of COPD is increasing worldwide and has become the fourth leading cause of death in the United States. Although cigarette smoking is by far the most important risk factor, only 10-20% of smokers develop symptomatic COPD, and less than 15% of the variation in lung function among smokers can be explained by the extent and duration of cigarette smoking. These data indicate that host and/or environmental factors other than simple exposure must contribute to disease pathogenesis. Family and twin studies suggest that at least some of this variance is genetic. In this chapter we discuss approaches to identify disease-causing genes and provide a current summary of the results of linkage and association studies.

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