Hydroxytyrosol and dopamine metabolites: Anti-aggregative effect and neuroprotective activity against α-synuclein-induced toxicity.

[1]  T. Richard,et al.  Oxyresveratrol and Gnetol Glucuronide Metabolites: Chemical Production, Structural Identification, Metabolism by Human and Rat Liver Fractions, and In Vitro Anti-inflammatory Properties , 2022, Journal of agricultural and food chemistry.

[2]  M. C. García-Parrilla,et al.  Anti-VEGF Effect of Bioactive Indolic Compounds and Hydroxytyrosol Metabolites , 2022, Foods.

[3]  C. Ríos,et al.  Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP+ Model of Parkinson’s Disease , 2021, Neurochemical Research.

[4]  C. Dobson,et al.  The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends , 2020, Nature Communications.

[5]  C. Follmer,et al.  In Vitro Protective Action of Monomeric and Fibrillar α-Synuclein on Neuronal Cells Exposed to the Dopaminergic Toxins Salsolinol and DOPAL. , 2020, ACS chemical neuroscience.

[6]  Amrendra P. Singh,et al.  Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson’s disease , 2020, Molecular Diversity.

[7]  D. Agard,et al.  Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism , 2020, bioRxiv.

[8]  M. Stefani,et al.  Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans , 2020, International journal of molecular sciences.

[9]  D. Goldstein,et al.  The catecholaldehyde hypothesis: where MAO fits in , 2019, Journal of Neural Transmission.

[10]  A. M. Troncoso,et al.  Melatonin, protocatechuic acid and hydroxytyrosol effects on vitagenes system against alpha-synuclein toxicity. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[11]  M. Bucciantini,et al.  Insight into the molecular mechanism underlying the inhibition of α-synuclein aggregation by hydroxytyrosol. , 2019, Biochemical pharmacology.

[12]  D. Sulzer,et al.  Dopamine, Oxidative Stress and Protein-Quinone Modifications in Parkinson's and Other Neurodegenerative Diseases. , 2019, Angewandte Chemie.

[13]  D. Eliezer,et al.  Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of α-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde. , 2018, ACS chemical neuroscience.

[14]  D. Eliezer,et al.  Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified α-synuclein. , 2018, Biochemical and biophysical research communications.

[15]  P. Dušek,et al.  Prevention of progression in Parkinson’s disease , 2018, BioMetals.

[16]  M. Motilva,et al.  Brain uptake of hydroxytyrosol and its main circulating metabolites: Protective potential in neuronal cells , 2018, Journal of Functional Foods.

[17]  A. M. Troncoso,et al.  Protective effects of hydroxytyrosol against α-synuclein toxicity on PC12 cells and fibril formation. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[18]  M. Bucciantini,et al.  Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates , 2018, Scientific Reports.

[19]  A. Mitchell,et al.  Quantitation of Oleuropein and Related Phenolics in Cured Spanish-Style Green, California-Style Black Ripe, and Greek-Style Natural Fermentation Olives. , 2018, Journal of agricultural and food chemistry.

[20]  A. M. Troncoso,et al.  In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid‐&bgr; Kinetics and Neuroprotection , 2018, Molecular nutrition & food research.

[21]  S. Lucchetti,et al.  Phenolics fate in table olives (Olea europaea L. cv. Nocellara del Belice) debittered using the Spanish and Castelvetrano methods. , 2017, Food research international.

[22]  M. Vendruscolo,et al.  The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation , 2017, Scientific Reports.

[23]  P. Hanson,et al.  SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease , 2017, BMC Neuroscience.

[24]  Deborah Penque,et al.  The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease , 2017, PLoS biology.

[25]  L. Bubacco,et al.  DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function , 2017, Scientific Reports.

[26]  A. M. Troncoso,et al.  Protocatechuic Acid: Inhibition of Fibril Formation, Destabilization of Preformed Fibrils of Amyloid-β and α-Synuclein, and Neuroprotection. , 2016, Journal of agricultural and food chemistry.

[27]  A. Bax,et al.  Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with Lysines of α-Synuclein. , 2016, Angewandte Chemie.

[28]  A. Pastor,et al.  Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol , 2016, Drug metabolism reviews.

[29]  C. Piñol,et al.  Differential absorption and metabolism of hydroxytyrosol and its precursors oleuropein and secoiridoids , 2016 .

[30]  D. Eliezer,et al.  Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL)* , 2015, The Journal of Biological Chemistry.

[31]  B. Tang,et al.  SIRT1 in the brain—connections with aging-associated disorders and lifespan , 2015, Front. Cell. Neurosci..

[32]  A. Singleton,et al.  Parkinson’s disease in GTP cyclohydrolase 1 mutation carriers , 2014, Brain : a journal of neurology.

[33]  V. Calabrese,et al.  Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer’s disease , 2014, Front. Pharmacol..

[34]  D. Eliezer,et al.  Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity , 2014, Front. Aging Neurosci..

[35]  P. McLean,et al.  Targeting heat shock proteins to modulate α-synuclein toxicity , 2014, Therapeutic advances in neurological disorders.

[36]  Rick Morimoto.  Creating a path from the heat shock response to therapeutics of protein-folding diseases: an interview with Rick Morimoto , 2014, Disease Models & Mechanisms.

[37]  H. Kelebek,et al.  Characterization of the Volatile, Phenolic and Antioxidant Properties of Monovarietal Olive Oil Obtained from cv. Halhali , 2013 .

[38]  Daniel Weindl,et al.  Complexity of dopamine metabolism , 2013, Cell Communication and Signaling.

[39]  D. Teplow,et al.  Effect of melatonin on α-synuclein self-assembly and cytotoxicity , 2012, Neurobiology of Aging.

[40]  J. Segura-Aguilar,et al.  Dopamine Oxidation and Autophagy , 2012, Parkinson's disease.

[41]  P. McLean,et al.  Protein degradation pathways in Parkinson’s disease: curse or blessing , 2012, Acta Neuropathologica.

[42]  Nikolaos Scarmeas,et al.  The association between Mediterranean diet adherence and Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[43]  Beixue Gao,et al.  Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2–mediated reversal of T-cell tolerance , 2012, Proceedings of the National Academy of Sciences.

[44]  M. Palma,et al.  Direct liquid chromatography method for the simultaneous quantification of hydroxytyrosol and tyrosol in red wines. , 2011, Journal of agricultural and food chemistry.

[45]  M. Haigis,et al.  Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases. , 2011, Current pharmaceutical design.

[46]  P. Brundin,et al.  A deadly spread: cellular mechanisms of α-synuclein transfer , 2011, Cell Death and Differentiation.

[47]  Fred H. Gage,et al.  In vivo demonstration that α-synuclein oligomers are toxic , 2011, Proceedings of the National Academy of Sciences.

[48]  M. Mattson,et al.  Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. , 2010, Antioxidants & redox signaling.

[49]  A. Braca,et al.  Phenolic compounds in olive oil and olive pomace from Cilento (Campania, Italy) and their antioxidant activity , 2010 .

[50]  D. Ehrnhoefer,et al.  EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity , 2010, Proceedings of the National Academy of Sciences.

[51]  P. Thonart,et al.  Antioxidant phenolic compounds loss during the fermentation of Chétoui olives , 2009 .

[52]  C. Pagliuca,et al.  Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models. , 2009, Molecular nutrition & food research.

[53]  Yu-Tse Wu,et al.  Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection. , 2009, Journal of chromatography. A.

[54]  E. Calabrese,et al.  Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis , 2009, BioFactors.

[55]  R. Mayeux,et al.  Mediterranean diet and mild cognitive impairment. , 2009, Archives of neurology.

[56]  W. Burke,et al.  Aggregation of α-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine , 2008, Acta Neuropathologica.

[57]  S. Sang,et al.  Biotransformation of green tea polyphenols and the biological activities of those metabolites. , 2007, Molecular pharmaceutics.

[58]  A. Macario,et al.  Chaperonopathies by Defect, Excess, or Mistake , 2007, Annals of the New York Academy of Sciences.

[59]  Brian C. Smith,et al.  Linking SIRT2 to Parkinson's disease. , 2007, ACS chemical biology.

[60]  Ruben Abagyan,et al.  Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease , 2007, Science.

[61]  Andre Fischer,et al.  SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis , 2007, The EMBO journal.

[62]  L. Estevinho,et al.  Table olives from Portugal: phenolic compounds, antioxidant potential, and antimicrobial activity. , 2006, Journal of agricultural and food chemistry.

[63]  Abhinav K. Jain,et al.  Phosphorylation of Tyrosine 568 Controls Nuclear Export of Nrf2* , 2006, Journal of Biological Chemistry.

[64]  E. Boselli,et al.  Phenolic composition and quality of white d.o.c. wines from Marche (Italy) , 2006 .

[65]  J. Growdon,et al.  Clinical and biochemical correlates of insoluble α-synuclein in dementia with Lewy bodies , 2006, Acta Neuropathologica.

[66]  D. Butterfield,et al.  Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance. , 2004, Antioxidants & redox signaling.

[67]  C. Mancuso.  Heme oxygenase and its products in the nervous system. , 2004, Antioxidants & redox signaling.

[68]  M. Komaitis,et al.  High performance liquid chromatography analysis of phenolic substances in Greek wines , 2004 .

[69]  D. Twelves,et al.  Systematic review of incidence studies of Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.

[70]  R. Foresti,et al.  Regulation of heme oxygenase-1 by redox signals involving nitric oxide. , 2002, Antioxidants & redox signaling.

[71]  Bruce A. Yankner,et al.  Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease , 2002, Nature Medicine.

[72]  M. Katan,et al.  Olive oil phenols are absorbed in humans. , 2002, The Journal of nutrition.

[73]  Michel Goedert,et al.  Parkinsons Disease and other α-Synucleinopathies , 2001 .

[74]  W. Burke,et al.  Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria. , 2001, Free radical biology & medicine.

[75]  S. Gottesman,et al.  Posttranslational quality control: folding, refolding, and degrading proteins. , 1999, Science.

[76]  W. Burke,et al.  Quantitation of 3,4-dihydroxyphenylacetaldehyde and 3, 4-dihydroxyphenylglycolaldehyde, the monoamine oxidase metabolites of dopamine and noradrenaline, in human tissues by microcolumn high-performance liquid chromatography. , 1999, Analytical biochemistry.

[77]  R. Calabrese,et al.  Identification and quantitation of hydroxytyrosol in Italian wines , 1998 .

[78]  S. Fahn,et al.  Neurodegeneration and neuroprotection in Parkinson disease , 2011, NeuroRX.

[79]  E. Esposito,et al.  Birth, life and death of dopaminergic neurons in the substantia nigra. , 2009, Journal of neural transmission. Supplementum.

[80]  S. Salek,et al.  A Review of the Health-Related Quality of Life and Economic Impact of Parkinson’s Disease , 2006, Drugs & aging.