Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
暂无分享,去创建一个
[1] Leach,et al. The in silico world of virtual libraries. , 2000, Drug discovery today.
[2] Jürgen Bajorath,et al. Distinguishing between Natural Products and Synthetic Molecules by Descriptor Shannon Entropy Analysis and Binary QSAR Calculations , 2000, J. Chem. Inf. Comput. Sci..
[3] Morton E. Munk,et al. A Novel Formalism To Characterize the Degree of Unsaturation of Organic Molecules , 2001, J. Chem. Inf. Comput. Sci..
[4] Jack W. Szostak,et al. Introduction: Combinatorial Chemistry. , 1997, Chemical reviews.
[5] Tudor I. Oprea,et al. Property distribution of drug-related chemical databases* , 2000, J. Comput. Aided Mol. Des..
[6] G. Crippen,et al. Prediction of Physicochemical Parameters by Atomic Contributions. , 1999 .
[7] Thomas Henkel,et al. Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds. , 1999, Angewandte Chemie.
[8] G L Verdine,et al. The combinatorial chemistry of nature. , 1996, Nature.
[9] G Klebe,et al. Energetic and entropic factors determining binding affinity in protein-ligand complexes. , 1997, Journal of receptor and signal transduction research.
[10] D G Hall,et al. Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: a comprehensive survey. , 2001, Journal of combinatorial chemistry.
[11] Jun Xu,et al. Drug-Like Index: A New Approach to Measure Drug-Like Compounds and Their Diversity. , 2001 .
[12] David J. Triggle,et al. 28 – THE TRANSITION FROM AGONIST TO ANTAGONIST ACTIVITY: SYMMETRY AND OTHER CONSIDERATIONS , 2003 .
[13] M. G. Finn,et al. Click Chemistry: Diverse Chemical Function from a Few Good Reactions , 2001 .
[14] G. Bemis,et al. Properties of known drugs. 2. Side chains. , 1999, Journal of medicinal chemistry.
[15] M. G. Finn,et al. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. , 2001, Angewandte Chemie.
[16] G. Bemis,et al. The properties of known drugs. 1. Molecular frameworks. , 1996, Journal of medicinal chemistry.
[17] G. Schneider,et al. Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries. , 2001, Journal of combinatorial chemistry.
[18] H. Kubinyi,et al. A scoring scheme for discriminating between drugs and nondrugs. , 1998, Journal of medicinal chemistry.
[19] Ajay,et al. Can we learn to distinguish between "drug-like" and "nondrug-like" molecules? , 1998, Journal of medicinal chemistry.
[20] F. Lombardo,et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.
[21] D. Dodds,et al. Application of biocatalysis and biotransformations to the synthesis of pharmaceuticals , 1997 .
[22] Robert Bywater,et al. Improving the Odds in Discriminating "Drug-like" from "Non Drug-like" Compounds , 2000, J. Chem. Inf. Comput. Sci..