Second generation stationary digital breast tomosynthesis system with faster scan time and wider angular span

Purpose The aim of this study was to characterize a new generation stationary digital breast tomosynthesis system with higher tube flux and increased angular span over a first generation system. Methods The linear CNT x‐ray source was designed, built, and evaluated to determine its performance parameters. The second generation system was then constructed using the CNT x‐ray source and a Hologic gantry. Upon construction, test objects and phantoms were used to characterize system resolution as measured by the modulation transfer function (MTF), and artifact spread function (ASF). Results The results indicated that the linear CNT x‐ray source was capable of stable operation at a tube potential of 49 kVp, and measured focal spot sizes showed source‐to‐source consistency with a nominal focal spot size of 1.1 mm. After construction, the second generation (Gen 2) system exhibited entrance surface air kerma rates two times greater the previous s‐DBT system. System in‐plane resolution as measured by the MTF is 7.7 cycles/mm, compared to 6.7 cycles/mm for the Gen 1 system. As expected, an increase in the z‐axis depth resolution was observed, with a decrease in the ASF from 4.30 mm to 2.35 mm moving from the Gen 1 system to the Gen 2 system as result of an increased angular span. Conclusions The results indicate that the Gen 2 stationary digital breast tomosynthesis system, which has a larger angular span, increased entrance surface air kerma, and faster image acquisition time over the Gen 1 s‐DBT system, results in higher resolution images. With the detector operating at full resolution, the Gen 2 s‐DBT system can achieve an in‐plane resolution of 7.7 cycles per mm, which is better than the current commercial DBT systems today, and may potentially result in better patient diagnosis.

[1]  A. Rodríguez-Ruiz,et al.  Evaluation of the technical performance of three different commercial digital breast tomosynthesis systems in the clinical environment. , 2016, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[2]  Tao Wu,et al.  A comparison of reconstruction algorithms for breast tomosynthesis. , 2004, Medical physics.

[3]  Jing Shan.  Development of a stationary chest tomosynthesis system using carbon nanotube x-ray source array , 2015 .

[4]  F Verhaegen,et al.  SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes , 2009, Physics in medicine and biology.

[5]  Otto Zhou,et al.  Dependency of image quality on system configuration parameters in a stationary digital breast tomosynthesis system. , 2013, Medical physics.

[6]  Francesca Caumo,et al.  Breast screening using 2D-mammography or integrating digital breast tomosynthesis (3D-mammography) for single-reading or double-reading--evidence to guide future screening strategies. , 2014, European journal of cancer.

[7]  Thomas Mertelmeier,et al.  Experimental validation of a three-dimensional linear system model for breast tomosynthesis. , 2008, Medical physics.

[8]  Martin J. Yaffe,et al.  Digital breast tomosynthesis geometry calibration , 2007, SPIE Medical Imaging.

[9]  Tao Wu,et al.  A new generation FFDM/tomosynthesis fusion system with selenium detector , 2010, Medical Imaging.

[10]  Lubomir M. Hadjiiski,et al.  A comparative study of limited-angle cone-beam reconstruction methods for breast tomosynthesis. , 2006, Medical physics.

[11]  Andrew D. A. Maidment,et al.  Dynamic reconstruction and rendering of 3D tomosynthesis images , 2011, Medical Imaging.

[12]  Hye-Suk Park,et al.  Optimization of configuration parameters in a newly developed digital breast tomosynthesis system , 2013, Journal of radiation research.

[13]  E Platin,et al.  Stationary intraoral digital tomosynthesis using a carbon nanotube X-ray source array. , 2015, Dento maxillo facial radiology.

[14]  A. Arieno,et al.  Digital Breast Tomosynthesis: Principles and Practice , 2016, Current Radiology Reports.

[15]  Kunio Doi,et al.  A simple method for determining the modulation transfer function in digital radiography , 1992, IEEE Trans. Medical Imaging.

[16]  Hee-Joung Kim,et al.  Optimization of the key imaging parameters for detection of microcalcifications in a newly developed digital breast tomosynthesis system. , 2013, Clinical imaging.

[17]  Ehsan Samei,et al.  How does c-view image quality compare with conventional 2D FFDM? , 2016, Medical physics.

[18]  Bo Zhao,et al.  Image artifacts in digital breast tomosynthesis: investigation of the effects of system geometry and reconstruction parameters using a linear system approach. , 2008, Medical physics.

[19]  I. Sechopoulos.  A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications. , 2013, Medical physics.

[20]  Otto Zhou,et al.  Initial clinical evaluation of stationary digital breast tomosynthesis , 2015, Medical Imaging.

[21]  Yueh Z. Lee,et al.  Comparison of a stationary digital breast tomosynthesis system to magnified 2D mammography using breast tissue specimens. , 2014, Academic radiology.

[22]  Alberto Tagliafico,et al.  Digital breast tomosynthesis: A practical approach , 2016 .

[23]  I. Sechopoulos.  A review of breast tomosynthesis. Part I. The image acquisition process. , 2013, Medical physics.

[24]  Yiheng Zhang,et al.  High resolution stationary digital breast tomosynthesis using distributed carbon nanotube x-ray source array. , 2012, Medical physics.

[25]  L. Tabár,et al.  Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening , 2003, The Lancet.

[26]  Manuela Durando,et al.  Characterisation of microcalcification clusters on 2D digital mammography (FFDM) and digital breast tomosynthesis (DBT): does DBT underestimate microcalcification clusters? Results of a multicentre study , 2014, European Radiology.

[27]  F Sprenger,et al.  Design and feasibility studies of a stationary digital breast tomosynthesis system. , 2011, Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment.

[28]  Ioannis Sechopoulos,et al.  Optimization of the acquisition geometry in digital tomosynthesis of the breast. , 2009, Medical physics.

[29]  Otto Zhou,et al.  Stationary chest tomosynthesis using a CNT x-ray source array , 2013, Medical Imaging.

[30]  Otto Zhou,et al.  Increased microcalcification visibility in lumpectomy specimens using a stationary digital breast tomosynthesis system , 2014, Medical Imaging.

[31]  Ian Shaw,et al.  Design and performance of the prototype full field breast tomosynthesis system with selenium based flat panel detector , 2005, SPIE Medical Imaging.

[32]  Stephen J. Glick,et al.  Effect of postreconstruction filter strength on microcalcification detection at different imaging doses in digital breast tomosynthesis: human and model observer studies , 2012, Medical Imaging.

[33]  Mark A Helvie,et al.  Digital mammography imaging: breast tomosynthesis and advanced applications. , 2010, Radiologic clinics of North America.

[34]  Xinhua Li,et al.  A generic geometric calibration method for tomographic imaging systems with flat-panel detectors--a detailed implementation guide. , 2010, Medical physics.

[35]  Otto Zhou,et al.  Adapted fan-beam volume reconstruction for stationary digital breast tomosynthesis , 2015, Medical Imaging.

[36]  C P Lawinski,et al.  A comparison of the accuracy of film-screen mammography, full-field digital mammography, and digital breast tomosynthesis. , 2012, Clinical radiology.

[37]  Anders Tingberg,et al.  Performance of one-view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the Malmö Breast Tomosynthesis Screening Trial, a population-based study , 2015, European Radiology.

[38]  Ehsan Samei,et al.  Optimized image acquisition for breast tomosynthesis in projection and reconstruction space. , 2009, Medical physics.