Hybrid Nanoclusters for Near-Infrared to Near-Infrared Upconverted Persistent Luminescence Bioimaging.

Persistent luminescence (PL) bioimaging provides an optimal method of eliminating autofluorescence for a higher resolution and sensitivity because of the absence of excitation light. However, ultraviolet light is still necessary in common energy charging processes, which limits its reactivation in vivo because of its low penetration depth. In the present study, we introduce a type of hybrid nanocluster (UCPL-NC) composed of upconversion nanoparticles, β-NaYbF4:Tm@NaYF4, and persistent nanoparticles, Zn1.1Ga1.8Ge0.1O4:0.5%Cr, which can be activated by a 980 nm laser and exhibits an afterglow at 700 nm to realize near-infrared (NIR) to NIR UCPL bioimaging. The PL of the UCPL-NCs can be reactivated even when covered with a 10 mm pork. We demonstrate that these polyethylene glycol-modified phospholipid-functionalized UCPL-NCs can be reactivated in vivo and applied in the PL lymphatic imaging on small animals.

[1]  Jianhua Hao,et al.  X-ray-Activated Near-Infrared Persistent Luminescent Probe for Deep-Tissue and Renewable in Vivo Bioimaging. , 2017, ACS applied materials & interfaces.

[2]  Ling Huang,et al.  Near-infrared light activated persistent luminescence nanoparticles via upconversion , 2017, Nano Research.

[3]  Wei Feng,et al.  Anti-Stokes shift luminescent materials for bio-applications. , 2017, Chemical Society reviews.

[4]  Xiu‐Ping Yan,et al.  Activatable Multifunctional Persistent Luminescence Nanoparticle/Copper Sulfide Nanoprobe for in Vivo Luminescence Imaging-Guided Photothermal Therapy. , 2016, ACS applied materials & interfaces.

[5]  Dong-Dong Zhang,et al.  Synthesis of GdAlO3:Mn4+,Ge4+@Au Core-Shell Nanoprobes with Plasmon-Enhanced Near-Infrared Persistent Luminescence for in Vivo Trimodality Bioimaging. , 2016, ACS applied materials & interfaces.

[6]  J. Qiu,et al.  Long Persistent Phosphors — From Fundamentals to Applications , 2016 .

[7]  Yang Li,et al.  Long persistent phosphors--from fundamentals to applications. , 2016, Chemical Society reviews.

[8]  Xiu‐Ping Yan,et al.  Penetrating Peptide-Bioconjugated Persistent Nanophosphors for Long-Term Tracking of Adipose-Derived Stem Cells with Superior Signal-to-Noise Ratio. , 2016, Analytical chemistry.

[9]  Jiye Shi,et al.  Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging. , 2016, ACS applied materials & interfaces.

[10]  H. Ju,et al.  Persistent luminescence nanoprobe for biosensing and lifetime imaging of cell apoptosis via time-resolved fluorescence resonance energy transfer. , 2015, Biomaterials.

[11]  B. Liu,et al.  Biocompatible Green and Red Fluorescent Organic Dots with Remarkably Large Two-Photon Action Cross Sections for Targeted Cellular Imaging and Real-Time Intravital Blood Vascular Visualization. , 2015, ACS applied materials & interfaces.

[12]  Bhupendra B. Srivastava,et al.  Persistent luminescent sub-10 nm Cr doped ZnGa2O4 nanoparticles by a biphasic synthesis route. , 2015, Chemical communications.

[13]  W. Fan,et al.  Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence , 2015, Journal of the American Chemical Society.

[14]  Gang Han,et al.  Persistent Luminescence: In Vivo Repeatedly Charging Near‐Infrared‐Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites (Adv. Sci. 3/2015) , 2015, Advanced Science.

[15]  Gang Han,et al.  In Vivo Repeatedly Charging Near‐Infrared‐Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites , 2015, Advanced science.

[16]  Ou Chen,et al.  Magneto-Fluorescent Core-Shell Supernanoparticles , 2014, Nature Communications.

[17]  Feng Liu,et al.  Photostimulable Near-Infrared Persistent Luminescent Nanoprobes for Ultrasensitive and Longitudinal Deep-Tissue Bio-Imaging , 2014, Theranostics.

[18]  Didier Gourier,et al.  The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells. , 2014, Nature materials.

[19]  Xiaogang Liu,et al.  Multicolor tuning of lanthanide-doped nanoparticles by single wavelength excitation. , 2014, Accounts of chemical research.

[20]  J. Ransohoff,et al.  Tracking gene and cell fate for therapeutic gain. , 2014, Nature materials.

[21]  R. Weissleder,et al.  Imaging macrophages with nanoparticles. , 2014, Nature materials.

[22]  Chun Li,et al.  A targeted approach to cancer imaging and therapy. , 2014, Nature materials.

[23]  Chun-Hua Yan,et al.  Paradigms and challenges for bioapplication of rare earth upconversion luminescent nanoparticles: small size and tunable emission/excitation spectra. , 2014, Accounts of chemical research.

[24]  Baran D. Sumer,et al.  A Broad Nanoparticle-Based Strategy for Tumor Imaging by Nonlinear Amplification of Microenvironment Signals , 2013, Nature materials.

[25]  Qiang Zhao,et al.  Functional near infrared-emitting Cr3+/Pr3+ co-doped zinc gallogermanate persistent luminescent nanoparticles with superlong afterglow for in vivo targeted bioimaging. , 2013, Journal of the American Chemical Society.

[26]  Shuyan Song,et al.  Rare earth fluorides upconversion nanophosphors: from synthesis to applications in bioimaging , 2013 .

[27]  Liang Yan,et al.  Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications , 2013, Advanced materials.

[28]  Ling-Dong Sun,et al.  Nd(3+)-sensitized upconversion nanophosphors: efficient in vivo bioimaging probes with minimized heating effect. , 2013, ACS nano.

[29]  B. Wall,et al.  Rare-earth-doped biological composites as in vivo shortwave infrared reporters , 2013, Nature Communications.

[30]  Feng Liu,et al.  Photostimulated near-infrared persistent luminescence as a new optical read-out from Cr3+-doped LiGa5O8 , 2013, Scientific Reports.

[31]  Kaibo Zheng,et al.  Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging. , 2013, Chemical Society Reviews.

[32]  Wei Feng,et al.  Luminescent chemodosimeters for bioimaging. , 2013, Chemical reviews.

[33]  Zhenda Lu,et al.  Colloidal nanoparticle clusters: functional materials by design. , 2012, Chemical Society reviews.

[34]  Paras N. Prasad,et al.  (α-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. , 2012, ACS nano.

[35]  Renren Deng,et al.  Tuning upconversion through energy migration in core-shell nanoparticles. , 2011, Nature materials.

[36]  Didier Gourier,et al.  Controlling electron trap depth to enhance optical properties of persistent luminescence nanoparticles for in vivo imaging. , 2011, Journal of the American Chemical Society.

[37]  O. Wolfbeis,et al.  Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging. , 2010, Current opinion in chemical biology.

[38]  Soojin Lim,et al.  NIR dyes for bioimaging applications. , 2010, Current opinion in chemical biology.

[39]  Taeghwan Hyeon,et al.  Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. , 2009, Chemical Society reviews.

[40]  Zhengquan Li,et al.  An efficient and user-friendly method for the synthesis of hexagonal-phase NaYF4:Yb, Er/Tm nanocrystals with controllable shape and upconversion fluorescence , 2008, Nanotechnology.

[41]  Jung Ho Yu,et al.  Designed Fabrication of a Multifunctional Polymer Nanomedical Platform for Simultaneous Cancer‐ Targeted Imaging and Magnetically Guided Drug Delivery , 2008 .

[42]  Didier Gourier,et al.  Nanoprobes with near-infrared persistent luminescence for in vivo imaging , 2007, Proceedings of the National Academy of Sciences.

[43]  Ya-Wen Zhang,et al.  High-quality sodium rare-earth fluoride nanocrystals: controlled synthesis and optical properties. , 2006, Journal of the American Chemical Society.

[44]  Swadeshmukul Santra,et al.  Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: a multifunctional probe for bioimaging. , 2005, Journal of the American Chemical Society.

[45]  R. Weissleder.  A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[46]  Zhengwei Pan,et al.  Sunlight-activated long-persistent luminescence in the near-infrared from Cr(3+)-doped zinc gallogermanates. , 2011, Nature materials.