The role of mitogen-activated protein (MAP) kinase in breast cancer
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R. McPherson | Rakesh Kumar | R. Santen | W. Yue | L. Adam | M. Jeng | R. Song | Rakesh Kumar
[1] R. Nicholson,et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). , 2001, Endocrinology.
[2] C. Wade,et al. Estrogen Receptor (ER)α and ERβ Exhibit Unique Pharmacologic Properties When Coupled to Activation of the Mitogen-Activated Protein Kinase Pathway. , 2001, Endocrinology.
[3] J. McCubrey,et al. Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf. , 2001, Advances in enzyme regulation.
[4] C. Pritchard,et al. MEK kinase activity is not necessary for Raf‐1 function , 2001, The EMBO journal.
[5] R. Marais,et al. S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3 , 2001, Molecular and Cellular Biology.
[6] M. Cobb,et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.
[7] R. Lefkowitz,et al. Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. , 2001, Current opinion in cell biology.
[8] B. Katzenellenbogen,et al. Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity , 2001, Cell.
[9] Robert G. Parton,et al. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity , 2001, Nature Cell Biology.
[10] P. Pelicci,et al. Evolution of Shc functions from nematode to human. , 2000, Current opinion in genetics & development.
[11] A. Lenferink,et al. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. , 2000, Cancer research.
[12] W. Kolch. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. , 2000, The Biochemical journal.
[13] K. Bland,et al. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. , 2000, Molecular endocrinology.
[14] William Rostène,et al. Hormonal regulation of apoptosis in breast cells and tissues , 2000, Steroids.
[15] E. Levin,et al. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. , 2000, Molecular endocrinology.
[16] J. Peyrat,et al. The mitogenic signaling pathway for fibroblast growth factor‐2 involves the tyrosine phosphorylation of cyclin D2 in MCF‐7 human breast cancer cells , 2000, FEBS letters.
[17] Ji-ping Wang,et al. Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells , 2000, Breast Cancer Research and Treatment.
[18] T. Sturgill,et al. A different function for a critical tryptophan in c-Raf and Hck , 2000, Oncogene.
[19] L. Altucci,et al. The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion , 2000, Molecular and Cellular Endocrinology.
[20] W. Kolch,et al. Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation* , 2000, The Journal of Biological Chemistry.
[21] S. Eppenberger-Castori,et al. Potential prognostic value of mitogen‐activated protein kinase activity for disease‐free survival of primary breast cancer patients , 2000, International journal of cancer.
[22] Nissi M. Varki,et al. Ras activation in human breast cancer , 2000, Breast Cancer Research and Treatment.
[23] Donna J. Webb,et al. Urokinase-type Plasminogen Activator Stimulates the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway and MCF-7 Cell Migration by a Mechanism That Requires Focal Adhesion Kinase, Src, and Shc , 2000, The Journal of Biological Chemistry.
[24] J. McLachlan,et al. Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. , 2000, International journal of oncology.
[25] M. H. Cobb,et al. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 , 2000, Current Biology.
[26] K. Olden,et al. Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase-dependent Pathway* , 2000, The Journal of Biological Chemistry.
[27] G. Palumbo,et al. 17β-Estradiol Inhibits Apoptosis in MCF-7 Cells, Inducing bcl-2 Expression via Two Estrogen-Responsive Elements Present in the Coding Sequence , 2000, Molecular and Cellular Biology.
[28] L. Mazzolini,et al. Interconnections between E2-dependent regulation of cell cycle progression and apoptosis in MCF-7 tumors growing on nude mice. , 2000, Experimental cell research.
[29] J. Marks,et al. Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[30] C. Lange,et al. Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[31] C. Watson,et al. Antibodies to the estrogen receptor‐α modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[32] K. Moelling,et al. Phosphorylation and regulation of Raf by Akt (protein kinase B). , 1999, Science.
[33] Yan Tang,et al. Effects of environmental estrogens on tumor necrosis factor α-mediated apoptosis in MCF-7 cells , 1999 .
[34] P. Budtz. Role of proliferation and apoptosis in net growth rates of human breast cancer cells (MCF‐7) treated with oestradiol and/or tamoxifen , 1999, Cell proliferation.
[35] S. Takenoshita,et al. Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[36] C. Watson,et al. Estrogen Receptor-α Detected on the Plasma Membrane of Aldehyde-Fixed GH3/B6/F10 Rat Pituitary Tumor Cells by Enzyme-Linked Immunocytochemistry. , 1999, Endocrinology.
[37] G. Cooper,et al. B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway , 1999, Molecular and Cellular Biology.
[38] W. Imagawa,et al. Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF. , 1999, Carcinogenesis.
[39] B. Calabretta,et al. Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. , 1999, Cancer research.
[40] B. McEwen,et al. Estrogen actions in the central nervous system. , 1999, Endocrine reviews.
[41] A. Bilancio,et al. Non‐transcriptional action of oestradiol and progestin triggers DNA synthesis , 1999, The EMBO journal.
[42] Giulio Superti‐Furga,et al. Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation , 1999, The EMBO journal.
[43] J. York,et al. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[44] D. Dorsa,et al. The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons , 1999, The Journal of Neuroscience.
[45] T. Pappas,et al. Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-α , 1999, Steroids.
[46] Xiaoping Guan,et al. Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways , 1999, The Journal of Neuroscience.
[47] G. Fricchione,et al. Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor. , 1999, Endocrinology.
[48] G. Greene,et al. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. , 1999, Molecular endocrinology.
[49] H. Frierson,et al. Activation of mitogen-activated protein kinase associated with prostate cancer progression. , 1999, Cancer research.
[50] K. Horwitz,et al. Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer , 1998, The Journal of Biological Chemistry.
[51] A. King,et al. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 , 1998, Nature.
[52] T. León‐Quinto,et al. Rapid insulinotropic effect of 17β‐estradiol via a plasma membrane receptor , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[53] Rakesh Kumar,et al. Estrogen Receptor Expression and Function in Long-Term Estrogen-Deprived Human Breast Cancer Cells* * This work was supported by Grants NIH-RO-1-65622-04 (to R.J.S.), HD-25719 (to M.A.S.), GM-55985 and CA-44579 (to T.P.B.), and CA-65746 (to R.K.). , 1998, Endocrinology.
[54] L. Murphy,et al. Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells. , 1998, Cancer research.
[55] E. Elion. Routing MAP Kinase Cascades , 1998, Science.
[56] Y. Lazebnik,et al. Caspases: enemies within. , 1998, Science.
[57] J C Reed,et al. Mitochondria and apoptosis. , 1998, Science.
[58] V. Dixit,et al. Death receptors: signaling and modulation. , 1998, Science.
[59] S. Cory,et al. The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.
[60] G. Evan,et al. A matter of life and cell death. , 1998, Science.
[61] U. Rapp,et al. Interaction between the Protein Kinase B-Raf and the α-Subunit of the 11S Proteasome Regulator , 1998 .
[62] P. W. Janes,et al. Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells , 1998, Oncogene.
[63] E. Mccleskey,et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor , 1998, Nature.
[64] S. L. Gonias,et al. Binding of Urokinase-type Plasminogen Activator to Its Receptor in MCF-7 Cells Activates Extracellular Signal-regulated Kinase 1 and 2 Which Is Required for Increased Cellular Motility* , 1998, The Journal of Biological Chemistry.
[65] C. Marshall,et al. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. , 1998, Science.
[66] Wen-rong Gong,et al. Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross‐talk with estrogen receptor , 1998, The EMBO journal.
[67] J. Blenis,et al. pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 , 1998, Molecular and Cellular Biology.
[68] J. Tesarik,et al. Nongenomic actions of steroid hormones in reproductive tissues. , 1998, Endocrine reviews.
[69] N. Ahn,et al. Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1)* , 1998, The Journal of Biological Chemistry.
[70] J. Sussenbach,et al. The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells , 1998, Oncogene.
[71] D. Green. A Myc-Induced Apoptosis Pathway Surfaces , 1997, Science.
[72] S. R. Datta,et al. Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.
[73] U. Eppenberger,et al. Tumor-necrosis factor-alpha modulates mitogen-activated protein kinase activity of epidermal-growth-factor-stimulated MCF-7 breast cancer cells. , 1997, European journal of biochemistry.
[74] E. Krebs,et al. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. , 1997, Endocrinology.
[75] J. Brugge,et al. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation , 1997, Molecular and cellular biology.
[76] S. Kato,et al. Rapid activation of MAP kinase by estrogen in the bone cell line. , 1997, Biochemical and biophysical research communications.
[77] S. Nass,et al. Defining a role for c-Myc in breast tumorigenesis , 1997, Breast Cancer Research and Treatment.
[78] G. Nuovo,et al. Hyperexpression of mitogen-activated protein kinase in human breast cancer. , 1997, The Journal of clinical investigation.
[79] L. Altucci,et al. Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. , 1997, Endocrinology.
[80] R. Frey,et al. Involvement of Extracellular Signal-regulated Kinase 2 and Stress-activated Protein Kinase/Jun N-Terminal Kinase Activation by Transforming Growth Factor β in the Negative Growth Control of Breast Cancer Cells , 1997 .
[81] N. Normanno,et al. Cripto Enhances the Tyrosine Phosphorylation of Shc and Activates Mitogen-activated Protein Kinase (MAPK) in Mammary Epithelial Cells* , 1997, The Journal of Biological Chemistry.
[82] G. Evan,et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.
[83] J. Ferrell. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. , 1996, Trends in biochemical sciences.
[84] A. Bilancio,et al. Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. , 1996, Cancer research.
[85] A. Bianco,et al. c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[86] L. Altucci,et al. 17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. , 1996, Oncogene.
[87] C. Peschle,et al. Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. , 1996, Cancer research.
[88] R. Simerly,et al. Hormonal Regulation of CREB Phosphorylation in the Anteroventral Periventricular Nucleus , 1996, The Journal of Neuroscience.
[89] D. Dorsa,et al. Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain. , 1996, Endocrinology.
[90] M. Lisanti,et al. Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains , 1996, The Journal of Biological Chemistry.
[91] L. Altucci,et al. Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors. , 1996, Biochemical and biophysical research communications.
[92] P. Bontempo,et al. Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells. , 1996, The EMBO journal.
[93] L. Altucci,et al. 17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. , 1996, Oncogene.
[94] L. E. Stevenson,et al. Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the RAS signaling pathway , 1996, International journal of cancer.
[95] Daniel Metzger,et al. Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.
[96] Thomas T. Y. Wang,et al. Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. , 1995, Cancer research.
[97] J. Tesarik,et al. Nongenomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. , 1995, The Journal of clinical endocrinology and metabolism.
[98] N. Qian,et al. Acetylcholine muscarinic receptor regulation of the Ras/Raf/MAP kinase pathway. , 1995, Life sciences.
[99] A. deFazio,et al. Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. , 1994, Oncogene.
[100] B. Katzenellenbogen,et al. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[101] J. Hancock,et al. N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization , 1994, Molecular and cellular biology.
[102] Walter Kolch,et al. Protein kinase Cα activates RAF-1 by direct phosphorylation , 1993, Nature.
[103] B. Vanderhyden,et al. A new, nongenomic estrogen action: the rapid release of intracellular calcium. , 1992, Endocrinology.
[104] R. Shiu,et al. Mechanism of estrogen activation of c-myc oncogene expression. , 1992, Oncogene.
[105] S. Batra. Effect of estrogen and progesterone treatment on calcium uptake by the myometrium and smooth muscle of the lower urinary tract. , 1986, European journal of pharmacology.
[106] C. M. Szego,et al. Estrogen action at endometrial membranes: alterations in luminal surface detectable within seconds , 1983, The Journal of cell biology.
[107] R. Pietras,et al. Metabolic and proliferative responses to estrogen by hepatocytes selected for plasma membrane binding‐sites specific for estradiol‐17β , 1979, Journal of cellular physiology.
[108] R. Pietras,et al. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells , 1977, Nature.
[109] R. Pietras,et al. Endometrial cell calcium and oestrogen action , 1975, Nature.
[110] R. McPherson,et al. Linkage of Rapid Estrogen Action to MAPK Activation by ER-Shc Association and Shc Pathway Activation , 2001 .
[111] X. F. Zhang,et al. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. , 2001, Recent progress in hormone research.
[112] Taylor Murray,et al. Cancer Statistics, 2001 , 2001, CA: a cancer journal for clinicians.
[113] N. Hynes,et al. Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. , 2001, Cancer research.
[114] J. Swiątecka,et al. Influence of estrogen, antiestrogen and UV-light on the balance between proliferation and apoptosis in MCF-7 breast adenocarcinoma cells culture. , 2000, Neoplasma.
[115] Rakesh Kumar,et al. Estradiol Hypersensitivity and Mitogen-Activated Protein Kinase Expression in Long-Term Estrogen Deprived Human Breast Cancer Cells in Vivo1. , 2000, Endocrinology.
[116] A. Marotta,et al. Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. , 1999, Anticancer research.