The role of mitogen-activated protein (MAP) kinase in breast cancer

[1]  R. Nicholson,et al.  Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). , 2001, Endocrinology.

[2]  C. Wade,et al.  Estrogen Receptor (ER)α and ERβ Exhibit Unique Pharmacologic Properties When Coupled to Activation of the Mitogen-Activated Protein Kinase Pathway. , 2001, Endocrinology.

[3]  J. McCubrey,et al.  Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf. , 2001, Advances in enzyme regulation.

[4]  C. Pritchard,et al.  MEK kinase activity is not necessary for Raf‐1 function , 2001, The EMBO journal.

[5]  R. Marais,et al.  S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3 , 2001, Molecular and Cellular Biology.

[6]  M. Cobb,et al.  Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. , 2001, Endocrine reviews.

[7]  R. Lefkowitz,et al.  Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. , 2001, Current opinion in cell biology.

[8]  B. Katzenellenbogen,et al.  Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity , 2001, Cell.

[9]  Robert G. Parton,et al.  GTP-dependent segregation of H-ras from lipid rafts is required for biological activity , 2001, Nature Cell Biology.

[10]  P. Pelicci,et al.  Evolution of Shc functions from nematode to human. , 2000, Current opinion in genetics & development.

[11]  A. Lenferink,et al.  Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. , 2000, Cancer research.

[12]  W. Kolch Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. , 2000, The Biochemical journal.

[13]  K. Bland,et al.  Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. , 2000, Molecular endocrinology.

[14]  William Rostène,et al.  Hormonal regulation of apoptosis in breast cells and tissues , 2000, Steroids.

[15]  E. Levin,et al.  Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. , 2000, Molecular endocrinology.

[16]  J. Peyrat,et al.  The mitogenic signaling pathway for fibroblast growth factor‐2 involves the tyrosine phosphorylation of cyclin D2 in MCF‐7 human breast cancer cells , 2000, FEBS letters.

[17]  Ji-ping Wang,et al.  Role of MAP kinase in the enhanced cell proliferation of long term estrogen deprived human breast cancer cells , 2000, Breast Cancer Research and Treatment.

[18]  T. Sturgill,et al.  A different function for a critical tryptophan in c-Raf and Hck , 2000, Oncogene.

[19]  L. Altucci,et al.  The antiestrogen ICI 182,780 inhibits proliferation of human breast cancer cells by interfering with multiple, sequential estrogen-regulated processes required for cell cycle completion , 2000, Molecular and Cellular Endocrinology.

[20]  W. Kolch,et al.  Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation* , 2000, The Journal of Biological Chemistry.

[21]  S. Eppenberger-Castori,et al.  Potential prognostic value of mitogen‐activated protein kinase activity for disease‐free survival of primary breast cancer patients , 2000, International journal of cancer.

[22]  Nissi M. Varki,et al.  Ras activation in human breast cancer , 2000, Breast Cancer Research and Treatment.

[23]  Donna J. Webb,et al.  Urokinase-type Plasminogen Activator Stimulates the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway and MCF-7 Cell Migration by a Mechanism That Requires Focal Adhesion Kinase, Src, and Shc , 2000, The Journal of Biological Chemistry.

[24]  J. McLachlan,et al.  Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. , 2000, International journal of oncology.

[25]  M. H. Cobb,et al.  Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 , 2000, Current Biology.

[26]  K. Olden,et al.  Arachidonic Acid Activates Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase 2 and Mediates Adhesion of a Human Breast Carcinoma Cell Line to Collagen Type IV through a p38 MAP Kinase-dependent Pathway* , 2000, The Journal of Biological Chemistry.

[27]  G. Palumbo,et al.  17β-Estradiol Inhibits Apoptosis in MCF-7 Cells, Inducing bcl-2 Expression via Two Estrogen-Responsive Elements Present in the Coding Sequence , 2000, Molecular and Cellular Biology.

[28]  L. Mazzolini,et al.  Interconnections between E2-dependent regulation of cell cycle progression and apoptosis in MCF-7 tumors growing on nude mice. , 2000, Experimental cell research.

[29]  J. Marks,et al.  Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. , 2000, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[30]  C. Lange,et al.  Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[31]  C. Watson,et al.  Antibodies to the estrogen receptor‐α modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  K. Moelling,et al.  Phosphorylation and regulation of Raf by Akt (protein kinase B). , 1999, Science.

[33]  Yan Tang,et al.  Effects of environmental estrogens on tumor necrosis factor α-mediated apoptosis in MCF-7 cells , 1999 .

[34]  P. Budtz Role of proliferation and apoptosis in net growth rates of human breast cancer cells (MCF‐7) treated with oestradiol and/or tamoxifen , 1999, Cell proliferation.

[35]  S. Takenoshita,et al.  Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[36]  C. Watson,et al.  Estrogen Receptor-α Detected on the Plasma Membrane of Aldehyde-Fixed GH3/B6/F10 Rat Pituitary Tumor Cells by Enzyme-Linked Immunocytochemistry. , 1999, Endocrinology.

[37]  G. Cooper,et al.  B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway , 1999, Molecular and Cellular Biology.

[38]  W. Imagawa,et al.  Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF. , 1999, Carcinogenesis.

[39]  B. Calabretta,et al.  Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt. , 1999, Cancer research.

[40]  B. McEwen,et al.  Estrogen actions in the central nervous system. , 1999, Endocrine reviews.

[41]  A. Bilancio,et al.  Non‐transcriptional action of oestradiol and progestin triggers DNA synthesis , 1999, The EMBO journal.

[42]  Giulio Superti‐Furga,et al.  Serine and tyrosine phosphorylations cooperate in Raf‐1, but not B‐Raf activation , 1999, The EMBO journal.

[43]  J. York,et al.  Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Dorsa,et al.  The Mitogen-Activated Protein Kinase Pathway Mediates Estrogen Neuroprotection after Glutamate Toxicity in Primary Cortical Neurons , 1999, The Journal of Neuroscience.

[45]  T. Pappas,et al.  Rapid actions of estrogens in GH3/B6 pituitary tumor cells via a plasma membrane version of estrogen receptor-α , 1999, Steroids.

[46]  Xiaoping Guan,et al.  Estrogen-Induced Activation of Mitogen-Activated Protein Kinase in Cerebral Cortical Explants: Convergence of Estrogen and Neurotrophin Signaling Pathways , 1999, The Journal of Neuroscience.

[47]  G. Fricchione,et al.  Estradiol coupling to endothelial nitric oxide stimulates gonadotropin-releasing hormone release from rat median eminence via a membrane receptor. , 1999, Endocrinology.

[48]  G. Greene,et al.  Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. , 1999, Molecular endocrinology.

[49]  H. Frierson,et al.  Activation of mitogen-activated protein kinase associated with prostate cancer progression. , 1999, Cancer research.

[50]  K. Horwitz,et al.  Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer , 1998, The Journal of Biological Chemistry.

[51]  A. King,et al.  The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 , 1998, Nature.

[52]  T. León‐Quinto,et al.  Rapid insulinotropic effect of 17β‐estradiol via a plasma membrane receptor , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[53]  Rakesh Kumar,et al.  Estrogen Receptor Expression and Function in Long-Term Estrogen-Deprived Human Breast Cancer Cells* * This work was supported by Grants NIH-RO-1-65622-04 (to R.J.S.), HD-25719 (to M.A.S.), GM-55985 and CA-44579 (to T.P.B.), and CA-65746 (to R.K.). , 1998, Endocrinology.

[54]  L. Murphy,et al.  Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells. , 1998, Cancer research.

[55]  E. Elion Routing MAP Kinase Cascades , 1998, Science.

[56]  Y. Lazebnik,et al.  Caspases: enemies within. , 1998, Science.

[57]  J C Reed,et al.  Mitochondria and apoptosis. , 1998, Science.

[58]  V. Dixit,et al.  Death receptors: signaling and modulation. , 1998, Science.

[59]  S. Cory,et al.  The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.

[60]  G. Evan,et al.  A matter of life and cell death. , 1998, Science.

[61]  U. Rapp,et al.  Interaction between the Protein Kinase B-Raf and the α-Subunit of the 11S Proteasome Regulator , 1998 .

[62]  P. W. Janes,et al.  Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells , 1998, Oncogene.

[63]  E. Mccleskey,et al.  Rap1 mediates sustained MAP kinase activation induced by nerve growth factor , 1998, Nature.

[64]  S. L. Gonias,et al.  Binding of Urokinase-type Plasminogen Activator to Its Receptor in MCF-7 Cells Activates Extracellular Signal-regulated Kinase 1 and 2 Which Is Required for Increased Cellular Motility* , 1998, The Journal of Biological Chemistry.

[65]  C. Marshall,et al.  Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. , 1998, Science.

[66]  Wen-rong Gong,et al.  Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross‐talk with estrogen receptor , 1998, The EMBO journal.

[67]  J. Blenis,et al.  pp90rsk1 Regulates Estrogen Receptor-Mediated Transcription through Phosphorylation of Ser-167 , 1998, Molecular and Cellular Biology.

[68]  J. Tesarik,et al.  Nongenomic actions of steroid hormones in reproductive tissues. , 1998, Endocrine reviews.

[69]  N. Ahn,et al.  Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1)* , 1998, The Journal of Biological Chemistry.

[70]  J. Sussenbach,et al.  The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells , 1998, Oncogene.

[71]  D. Green A Myc-Induced Apoptosis Pathway Surfaces , 1997, Science.

[72]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[73]  U. Eppenberger,et al.  Tumor-necrosis factor-alpha modulates mitogen-activated protein kinase activity of epidermal-growth-factor-stimulated MCF-7 breast cancer cells. , 1997, European journal of biochemistry.

[74]  E. Krebs,et al.  Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. , 1997, Endocrinology.

[75]  J. Brugge,et al.  Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation , 1997, Molecular and cellular biology.

[76]  S. Kato,et al.  Rapid activation of MAP kinase by estrogen in the bone cell line. , 1997, Biochemical and biophysical research communications.

[77]  S. Nass,et al.  Defining a role for c-Myc in breast tumorigenesis , 1997, Breast Cancer Research and Treatment.

[78]  G. Nuovo,et al.  Hyperexpression of mitogen-activated protein kinase in human breast cancer. , 1997, The Journal of clinical investigation.

[79]  L. Altucci,et al.  Estrogen induces early and timed activation of cyclin-dependent kinases 4, 5, and 6 and increases cyclin messenger ribonucleic acid expression in rat uterus. , 1997, Endocrinology.

[80]  R. Frey,et al.  Involvement of Extracellular Signal-regulated Kinase 2 and Stress-activated Protein Kinase/Jun N-Terminal Kinase Activation by Transforming Growth Factor β in the Negative Growth Control of Breast Cancer Cells , 1997 .

[81]  N. Normanno,et al.  Cripto Enhances the Tyrosine Phosphorylation of Shc and Activates Mitogen-activated Protein Kinase (MAPK) in Mammary Epithelial Cells* , 1997, The Journal of Biological Chemistry.

[82]  G. Evan,et al.  Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB , 1997, Nature.

[83]  J. Ferrell Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. , 1996, Trends in biochemical sciences.

[84]  A. Bilancio,et al.  Estradiol activation of human colon carcinoma-derived Caco-2 cell growth. , 1996, Cancer research.

[85]  A. Bianco,et al.  c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[86]  L. Altucci,et al.  17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. , 1996, Oncogene.

[87]  C. Peschle,et al.  Apoptotic response to oncogenic stimuli: cooperative and antagonistic interactions between c-myb and the growth suppressor p53. , 1996, Cancer research.

[88]  R. Simerly,et al.  Hormonal Regulation of CREB Phosphorylation in the Anteroventral Periventricular Nucleus , 1996, The Journal of Neuroscience.

[89]  D. Dorsa,et al.  Estrogen rapidly induces the phosphorylation of the cAMP response element binding protein in rat brain. , 1996, Endocrinology.

[90]  M. Lisanti,et al.  Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains , 1996, The Journal of Biological Chemistry.

[91]  L. Altucci,et al.  Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors. , 1996, Biochemical and biophysical research communications.

[92]  P. Bontempo,et al.  Tyrosine kinase/p21ras/MAP‐kinase pathway activation by estradiol‐receptor complex in MCF‐7 cells. , 1996, The EMBO journal.

[93]  L. Altucci,et al.  17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation. , 1996, Oncogene.

[94]  L. E. Stevenson,et al.  Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the RAS signaling pathway , 1996, International journal of cancer.

[95]  Daniel Metzger,et al.  Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.

[96]  Thomas T. Y. Wang,et al.  Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. , 1995, Cancer research.

[97]  J. Tesarik,et al.  Nongenomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. , 1995, The Journal of clinical endocrinology and metabolism.

[98]  N. Qian,et al.  Acetylcholine muscarinic receptor regulation of the Ras/Raf/MAP kinase pathway. , 1995, Life sciences.

[99]  A. deFazio,et al.  Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. , 1994, Oncogene.

[100]  B. Katzenellenbogen,et al.  Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[101]  J. Hancock,et al.  N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization , 1994, Molecular and cellular biology.

[102]  Walter Kolch,et al.  Protein kinase Cα activates RAF-1 by direct phosphorylation , 1993, Nature.

[103]  B. Vanderhyden,et al.  A new, nongenomic estrogen action: the rapid release of intracellular calcium. , 1992, Endocrinology.

[104]  R. Shiu,et al.  Mechanism of estrogen activation of c-myc oncogene expression. , 1992, Oncogene.

[105]  S. Batra Effect of estrogen and progesterone treatment on calcium uptake by the myometrium and smooth muscle of the lower urinary tract. , 1986, European journal of pharmacology.

[106]  C. M. Szego,et al.  Estrogen action at endometrial membranes: alterations in luminal surface detectable within seconds , 1983, The Journal of cell biology.

[107]  R. Pietras,et al.  Metabolic and proliferative responses to estrogen by hepatocytes selected for plasma membrane binding‐sites specific for estradiol‐17β , 1979, Journal of cellular physiology.

[108]  R. Pietras,et al.  Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells , 1977, Nature.

[109]  R. Pietras,et al.  Endometrial cell calcium and oestrogen action , 1975, Nature.

[110]  R. McPherson,et al.  Linkage of Rapid Estrogen Action to MAPK Activation by ER-Shc Association and Shc Pathway Activation , 2001 .

[111]  X. F. Zhang,et al.  Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. , 2001, Recent progress in hormone research.

[112]  Taylor Murray,et al.  Cancer Statistics, 2001 , 2001, CA: a cancer journal for clinicians.

[113]  N. Hynes,et al.  Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. , 2001, Cancer research.

[114]  J. Swiątecka,et al.  Influence of estrogen, antiestrogen and UV-light on the balance between proliferation and apoptosis in MCF-7 breast adenocarcinoma cells culture. , 2000, Neoplasma.

[115]  Rakesh Kumar,et al.  Estradiol Hypersensitivity and Mitogen-Activated Protein Kinase Expression in Long-Term Estrogen Deprived Human Breast Cancer Cells in Vivo1. , 2000, Endocrinology.

[116]  A. Marotta,et al.  Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer. , 1999, Anticancer research.