Behavioral Neuroscience: No Easy Path from Genes to Cognition

Two recent studies illustrate the limits of a strictly molecular approach toward understanding learning and memory.

[1]  L. Lyons,et al.  Massed Training-Induced Intermediate-Term Operant Memory in Aplysia Requires Protein Synthesis and Multiple Persistent Kinase Cascades , 2012, The Journal of Neuroscience.

[2]  Greg Villareal,et al.  Role of Protein Kinase C in the Induction and Maintenance of Serotonin-Dependent Enhancement of the Glutamate Response in Isolated Siphon Motor Neurons of Aplysia californica , 2009, The Journal of Neuroscience.

[3]  D. Glanzman,et al.  Olfactory habituation: Fresh insights from flies , 2011, Proceedings of the National Academy of Sciences.

[4]  Alcino J. Silva,et al.  Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein , 1994, Cell.

[5]  E. Pastalkova,et al.  Storage of Spatial Information by the Maintenance Mechanism of LTP , 2006, Science.

[6]  R G M Morris,et al.  Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[7]  D. Glanzman,et al.  Protein Kinase M Maintains Long-Term Sensitization and Long-Term Facilitation in Aplysia , 2011, The Journal of Neuroscience.

[8]  L. Lyons,et al.  PKA and PKC are required for long-term but not short-term in vivo operant memory in Aplysia. , 2010, Learning & memory.

[9]  Subhabrata Sanyal,et al.  Plasticity of local GABAergic interneurons drives olfactory habituation , 2011, Proceedings of the National Academy of Sciences.

[10]  M. Kirkpatrick.  Reinforcement and divergence under assortative mating , 2000, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[11]  André A Fenton,et al.  PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories , 2008, PLoS biology.

[12]  D. Levin.  REPRODUCTIVE CHARACTER DISPLACEMENT IN PHLOX , 1985, Evolution; international journal of organic evolution.

[13]  Yadin Dudai,et al.  Boundary conditions for the maintenance of memory by PKMzeta in neocortex. , 2009, Learning & memory.

[14]  M. Fanselow,et al.  Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. , 1994, Behavioral neuroscience.

[15]  C. Giovanni Galizia,et al.  Odor Coding in Insects , 2010 .

[16]  Sheena A. Josselyn,et al.  Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala , 2001, The Journal of Neuroscience.

[17]  M. Rausher,et al.  Pollinator-Mediated Selection on Flower Color Allele Drives Reinforcement , 2012, Science.

[18]  M. Rausher,et al.  MOLECULAR SIGNATURES OF SELECTION ON REPRODUCTIVE CHARACTER DISPLACEMENT OF FLOWER COLOR IN PHLOX DRUMMONDII , 2012, Evolution; international journal of organic evolution.

[19]  S. Tonegawa,et al.  The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory , 1996, Cell.

[20]  Eric R Kandel,et al.  A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia , 1995, Neuron.

[21]  M. Rausher,et al.  Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii , 2011, Nature.

[22]  Y. Dudai,et al.  Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKMζ , 2007, Science.

[23]  S. Jager,et al.  Rapid Erasure of Long-Term Memory Associations in the Cortex by an Inhibitor of PKM z , 2009 .

[24]  D. Glanzman,et al.  Synaptic Facilitation and Behavioral Dishabituation in Aplysia: Dependence on Release of Ca2+ from Postsynaptic Intracellular Stores, Postsynaptic Exocytosis, and Modulation of Postsynaptic AMPA Receptor Efficacy , 2005, The Journal of Neuroscience.

[25]  Mark Kirkpatrick,et al.  Speciation by Natural and Sexual Selection: Models and Experiments , 2002, The American Naturalist.

[26]  Michael A Sutton,et al.  Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1 , 2002, Integrative and comparative biology.

[27]  Michael Davis,et al.  Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala , 1990, Nature.