Hybrid method for the chemical master equation

In order to make the solution of the chemical master equation computationally tractable, it is approximated in two different ways: The first two moments of the probability density function are computed or a macroscopic description is coupled to the master equation. In this way the computational complexity is reduced from exponential to polynomial growth of the work in the number of reacting chemical species and the dimension of the problem is lowered. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)