(Imidazol‐2‐yl)methyl‐1,3‐propanediones: Regioselective C–H Functionalization of the Imidazole Ring by Acylacetylene/Aldehyde Pairs

The metal-free regioselective C-2–H functionalization of 1-substituted imidazoles has been effected by a cascade reaction with aromatic or heteroaromatic aldehydes and acylacetylenes under mild conditions (55–60 °C, MeCN) to give (imidazol-2-yl)methyl-1,3-propanediones in 22–77 %, mainly 40–70 % yields.

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