Soft network composite materials with deterministic and bio-inspired designs

Hard and soft structural composites found in biology provide inspiration for the design of advanced synthetic materials. Many examples of bio-inspired hard materials can be found in the literature; far less attention has been devoted to soft systems. Here we introduce deterministic routes to low-modulus thin film materials with stress/strain responses that can be tailored precisely to match the non-linear properties of biological tissues, with application opportunities that range from soft biomedical devices to constructs for tissue engineering. The approach combines a low-modulus matrix with an open, stretchable network as a structural reinforcement that can yield classes of composites with a wide range of desired mechanical responses, including anisotropic, spatially heterogeneous, hierarchical and self-similar designs. Demonstrative application examples in thin, skin-mounted electrophysiological sensors with mechanics precisely matched to the human epidermis and in soft, hydrogel-based vehicles for triggered drug release suggest their broad potential uses in biomedical devices.

[1]  Elaine Nicpon Marieb,et al.  Study Guide: Human Anatomy & Physiology , 1998 .

[2]  Dae-Hyeong Kim,et al.  Multifunctional wearable devices for diagnosis and therapy of movement disorders. , 2014, Nature nanotechnology.

[3]  Stephen A. Morin,et al.  Camouflage and Display for Soft Machines , 2012, Science.

[4]  M. Ashby,et al.  Micro-architectured materials: past, present and future , 2010, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[5]  Tetsuya Matoba,et al.  Cyclophilin A enhances vascular oxidative stress and development of angiotensin II-induced aortic aneurysms , 2009, Nature Medicine.

[6]  Cecilia Laschi,et al.  Soft robotics: a bioinspired evolution in robotics. , 2013, Trends in biotechnology.

[7]  M. Ashby,et al.  The topological design of multifunctional cellular metals , 2001 .

[8]  Lorna J. Gibson,et al.  Size effects in ductile cellular solids. Part I: modeling , 2001 .

[9]  Dennis Normile,et al.  Clinical Trials Guidelines at Odds With U.S. Policy , 2008, Science.

[10]  Ray Vanderby,et al.  Subfailure damage in ligament: a structural and cellular evaluation. , 2002, Journal of applied physiology.

[11]  Markus J. Buehler,et al.  Nonlinear material behaviour of spider silk yields robust webs , 2012, Nature.

[12]  Alexander Huber,et al.  Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold. , 2011, Biomaterials.

[13]  Elena Aikawa Calcific Aortic Valve Disease , 2013 .

[14]  Koichiro Komatsu,et al.  Mechanical Strength and Viscoelastic Response of the Periodontal Ligament in Relation to Structure , 2009, Journal of dental biomechanics.

[15]  R. Lakes Materials with structural hierarchy , 1993, Nature.

[16]  Zhiyong Tang,et al.  Nanostructured artificial nacre , 2003, Nature materials.

[17]  Luis Dorfmann The mechanics of soft biological systems , 2013 .

[18]  Sindy K. Y. Tang,et al.  Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity , 2011, Nature.

[19]  Adam J. Stevenson,et al.  Strong, tough and stiff bioinspired ceramics from brittle constituents. , 2014, Nature materials.

[20]  Michel Destrade,et al.  Characterization of the anisotropic mechanical properties of excised human skin. , 2013, Journal of the mechanical behavior of biomedical materials.

[21]  M. Meyers,et al.  Structural Biological Materials: Critical Mechanics-Materials Connections , 2013, Science.

[22]  M. Ashby Overview No. 80: On the engineering properties of materials , 1989 .

[23]  Yonggang Huang,et al.  Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations , 2008, Proceedings of the National Academy of Sciences.

[24]  L. Kaufman,et al.  Strain stiffening in collagen I networks. , 2013, Biopolymers.

[25]  G. Mayer,et al.  Rigid Biological Systems as Models for Synthetic Composites , 2005, Science.

[26]  S. Weiner,et al.  Design strategies in mineralized biological materials , 1997 .

[27]  Sheng Xu,et al.  A hierarchical computational model for stretchable interconnects with fractal-inspired designs , 2014 .

[28]  Wei Wang,et al.  Nano-structured smart hydrogels with rapid response and high elasticity , 2013, Nature Communications.

[29]  Sanat S Bhole,et al.  Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin , 2014, Science.

[30]  Yoshimitsu Kuroyanagi,et al.  Design of artificial skin , 1996 .

[31]  M. Kaltenbrunner,et al.  An ultra-lightweight design for imperceptible plastic electronics , 2013, Nature.

[32]  C. Otto,et al.  Calcific aortic valve disease: outflow obstruction is the end stage of a systemic disease process. , 2009, European heart journal.

[33]  Jung Woo Lee,et al.  Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring , 2014, Nature Communications.

[34]  R. Ritchie,et al.  Tough, Bio-Inspired Hybrid Materials , 2008, Science.

[35]  Michael F. Ashby,et al.  On materials and shape , 1991 .

[36]  T van Dillen,et al.  Alternative explanation of stiffening in cross-linked semiflexible networks. , 2005, Physical review letters.

[37]  Mark G Allen,et al.  Generation of Spatially Aligned Collagen Fiber Networks Through Microtransfer Molding , 2014, Advanced healthcare materials.

[38]  J. Aizenberg,et al.  Skeleton of Euplectella sp.: Structural Hierarchy from the Nanoscale to the Macroscale , 2005, Science.

[39]  L. Mahadevan,et al.  Self-Organization of a Mesoscale Bristle into Ordered, Hierarchical Helical Assemblies , 2009, Science.

[40]  M. Ashby,et al.  FOAM TOPOLOGY BENDING VERSUS STRETCHING DOMINATED ARCHITECTURES , 2001 .

[41]  I. Yannas,et al.  Design of an artificial skin. I. Basic design principles. , 1980, Journal of biomedical materials research.

[42]  E. Terentjev,et al.  Mechanics of biological networks: from the cell cytoskeleton to connective tissue. , 2014, Soft matter.

[43]  Takao Someya Stretchable Electronics: SOMEYA:STRETCHABLE ELECT O-BK , 2012 .

[44]  Z. Suo,et al.  Compliant thin film patterns of stiff materials as platforms for stretchable electronics , 2005 .

[45]  Yonggang Huang,et al.  Materials and Mechanics for Stretchable Electronics , 2010, Science.

[46]  Robert Langer,et al.  Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients , 2013, Science.

[47]  Clément Sanchez,et al.  Biomimetism and bioinspiration as tools for the design of innovative materials and systems , 2005, Nature materials.

[48]  Christine Ortiz,et al.  Bioinspired Structural Materials , 2008, Science.

[49]  D. Tyler,et al.  Stimuli-Responsive Polymer Nanocomposites Inspired by the Sea Cucumber Dermis , 2008, Science.

[50]  Ludwig J. Gauckler,et al.  Bioinspired Design and Assembly of Platelet Reinforced Polymer Films , 2008, Science.

[51]  Oliver A. Shergold,et al.  The uniaxial stress versus strain response of pig skin and silicone rubber at low and high strain rates , 2006 .

[52]  Michael F. Ashby,et al.  Overview No. 92: Materials and shape , 1991 .

[53]  Jonathan A. Fan,et al.  Stretchable batteries with self-similar serpentine interconnects and integrated wireless recharging systems , 2013, Nature Communications.

[54]  D. Holdstock Past, present--and future? , 2005, Medicine, conflict, and survival.