论文信息 - Laser-assisted detection of endogenous porphyrins in malignant diseases

Laser-assisted detection of endogenous porphyrins in malignant diseases

Visualization of earlystagecancer turnsout to be a keypoint in dinical oncology. Ruorescence detection of systemicallyadministered dyes provento accumulate in tumors is one type of diagnostic procedure. The occurrence of endogenous chromophores in malignant tissue has been observed through laserinduced fluorescence in the red spectral range between 550nm and 750nm. Following lumination aftemating between violet and blue lines from a Kr-laser, an optkal mu1tkhanne1 analyser has detected fluorescence in defined areas wfthin chemically induced bladder tumors in rats. The same technique has also been used for the quantitative comparison of fluorescence in human gastrointestinal tumors in nude mice in-vivo. Results show that endogenous porphynns are present in rat bladder tumors as well as in gastrointestinal tumors in nude mice. A correlation between the porphyrin-related fluorescence signal and the histopathological examination indicates that the porphyrin content is dependent upon the tumor grading.

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