Loss of surface IgD by human B lymphocytes during polyclonal activation*

Surface and cytoplasmic immunoglobulins were studied by direct immunofluorescence in pokeweed mitogen‐stimulated cultures of human blood lymphocytes. The results compared to those of studies of unstimulated cultures and of fresh normal lymphocytes showed a striking decrease in surface IgD during terminal maturation of B lymphocytes into plasma cells. The number of cells which expressed IgG Fc receptor also decreased, although to a lesser extent.

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