Stevens-Johnson syndrome following concurrent phenytoin and holocranial radiotherapy

t o the editor, Antiepileptic drugs (AEDs) are an essential component of management of patients with primary or meta static central nervous system (CNS) tumors presenting with seizure activity, with phenytoin being one of the commonest drugs employed in this scenario. A large majority of these patients also require use of systemic steroids and cranial radiotherapy for man agement of their symptoms. we present a patient with CNS-metastatic breast cancer, who developed a severe cutaneous reaction to a combination of the above modalities, in order to highlight the importance of identifying and anticipating this potentially fatal but pre