KORA-gen - Resource for Population Genetics, Controls and a Broad Spectrum of Disease Phenotypes

KORA-gen is a resource for genetic epidemiological research, based on the KORA platform (Cooperative Health Research in the Region of Augsburg). Biosamples and phenotypic characteristics as well as environmental parameters of 18,000 adults from Augsburg and the surrounding counties are available. The age range of the participants was 25 to 74 years of recruitment and is 30 to 90 years in 2005. KORA-gen can be used by external partners. Interested parties can inform themselves interactively via internet about the available data and the rules of access. The genotypic data base is a common resource of all partners.

[1]  A. Peters,et al.  Partikel in der Außenluft erhöhen das Risiko für Herz-Kreislauf-Erkrankungen , 2005 .

[2]  A. Schneider,et al.  Fall-Kohorten-Studien: Ein effektives Design zur Untersuchung von Biomarkern als Risikofaktoren für chronische Krankheiten - Darstellung am Beispiel der MONICA/KORA Augsburg Fall-Kohorten-Studie 1984 - 2002 , 2005 .

[3]  C. Meisinger,et al.  The MONICA Augsburg surveys--basis for prospective cohort studies. , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[4]  R Holle,et al.  KORA - A Research Platform for Population Based Health Research , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[5]  R. Holle,et al.  Genetics of Type 2 Diabetes: Impact of Interleukin-6 Gene Variants , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[6]  C. Hengstenberg,et al.  Cardiovascular phenotypes and functional parameters in the general population--results of the MONICA/KORA studies. , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[7]  Genetic diversity in german and European populations: looking for substructures and genetic patterns. , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[8]  R Holle,et al.  Inflammation and Type 2 Diabetes: Results from KORA Augsburg , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[9]  C. Meisinger,et al.  Systemic low-grade inflammation and risk of coronary heart disease: results from the MONICA/KORA Augsburg cohort studies. , 2005, Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)).

[10]  R. Holle,et al.  Association of Humoral Immunity to Human Hsp60 with the IL-6 Gene Polymorphism C-174G in Patients with Type 2 Diabetes and Controls , 2005, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[11]  Thomas Meitinger,et al.  Linkage disequilibrium patterns and tagSNP transferability among European populations. , 2005, American journal of human genetics.

[12]  R. Holle,et al.  Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes. , 2004, The Journal of clinical endocrinology and metabolism.

[13]  H. Wichmann,et al.  Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults , 2004, Journal of Medical Genetics.

[14]  Francis S. Collins,et al.  The case for a US prospective cohort study of genes and environment , 2004, Nature.

[15]  T. Gudermann,et al.  Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. , 2004, American journal of human genetics.

[16]  Jochen Hampe,et al.  High-resolution SNP scan of chromosome 6p21 in pooled samples from patients with complex diseases. , 2003, Genomics.

[17]  M. Wjst,et al.  Further Genetic Heterogeneity for Autosomal Dominant Human Sutural Cataracts , 2003, Ophthalmic Research.

[18]  Jocelyn Kaiser,et al.  Population Databases Boom, From Iceland to the U.S. , 2002, Science.

[19]  W. Eaton,et al.  The logic for a conception-to-death cohort study. , 2002, Annals of epidemiology.

[20]  Matthias Wjst,et al.  Large‐scale determination of SNP allele frequencies in DNA pools using MALDI‐TOF mass spectrometry , 2002, Human mutation.

[21]  W. Rathmann,et al.  Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors , 2002, Diabetologia.

[22]  Walter C Willett,et al.  Balancing Life-Style and Genomics Research for Disease Prevention , 2002, Science.

[23]  E A Thompson,et al.  Linkage disequilibrium mapping: the role of population history, size, and structure. , 2001, Advances in genetics.

[24]  J. Weitzman,et al.  Linkage disequilibrium , 2001, Genome Biology.

[25]  崇 韮澤.  ＭＡＬＤＩ-ＴＯＦ-ＭＳ , 1996 .