Redox signaling loops in the unfolded protein response.

[1]  C. Glorieux,et al.  Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: implications for tumor recurrence. , 2012, Free radical biology & medicine.

[2]  A. Benham.  The protein disulfide isomerase family: key players in health and disease. , 2012, Antioxidants & redox signaling.

[3]  D. Pappin,et al.  H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response , 2011, Science Signaling.

[4]  J. McClintick,et al.  The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress , 2011, Molecular biology of the cell.

[5]  M. Wise,et al.  Role of Pro-oncogenic Protein Disulfide Isomerase (PDI) Family Member Anterior Gradient 2 (AGR2) in the Control of Endoplasmic Reticulum Homeostasis* , 2011, The Journal of Biological Chemistry.

[6]  M. Bentires-Alj,et al.  Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. , 2011, The Biochemical journal.

[7]  N. Bulleid,et al.  Multiple ways to make disulfides. , 2011, Trends in biochemical sciences.

[8]  J. Jassem,et al.  Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer , 2011, Drugs.

[9]  I. Braakman,et al.  Protein folding and modification in the mammalian endoplasmic reticulum. , 2011, Annual review of biochemistry.

[10]  D. Hebert,et al.  Characterization of Early EDEM1 Protein Maturation Events and Their Functional Implications* , 2011, The Journal of Biological Chemistry.

[11]  K. Inaba,et al.  Molecular Bases of Cyclic and Specific Disulfide Interchange between Human ERO1α Protein and Protein-disulfide Isomerase (PDI)* , 2011, The Journal of Biological Chemistry.

[12]  E. Chevet,et al.  Differential expression of the anterior gradient protein‐2 is a conserved feature during morphogenesis and carcinogenesis of the biliary tree , 2011, Liver international : official journal of the International Association for the Study of the Liver.

[13]  J. Hoseki,et al.  Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5. , 2011, Molecular cell.

[14]  F. Haj,et al.  Differential Regulation of Endoplasmic Reticulum Stress by Protein Tyrosine Phosphatase 1B and T Cell Protein Tyrosine Phosphatase* , 2011, The Journal of Biological Chemistry.

[15]  N. Bulleid,et al.  Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum , 2010, The EMBO journal.

[16]  D. Ron,et al.  Disulphide production by Ero1α–PDI relay is rapid and effectively regulated , 2010, The EMBO journal.

[17]  C. Hetz,et al.  HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction , 2010, PLoS biology.

[18]  G. Bánhegyi,et al.  Redox control of endoplasmic reticulum function. , 2010, Antioxidants & redox signaling.

[19]  C. Kahn,et al.  A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response , 2010, Nature Medicine.

[20]  M. Permutt,et al.  Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. , 2010, The Journal of clinical investigation.

[21]  S. Lipkin,et al.  Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. , 2010, Developmental biology.

[22]  C. Futter,et al.  Membrane contacts between endosomes and ER provide sites for PTP1B–epidermal growth factor receptor interaction , 2010, Nature Cell Biology.

[23]  Abhinav K. Jain,et al.  Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance , 2009, Journal of Cell Science.

[24]  R. Schekman,et al.  In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles , 2009, Proceedings of the National Academy of Sciences.

[25]  M. Kitamura,et al.  Biphasic, bidirectional regulation of NF-kappaB by endoplasmic reticulum stress. , 2009, Antioxidants & redox signaling.

[26]  J. Weissman,et al.  Regulated Ire1-dependent decay of messenger RNAs in mammalian cells , 2009, The Journal of cell biology.

[27]  Yasuhiro Nakagami,et al.  The protein disulfide isomerase AGR2 is essential for production of intestinal mucus , 2009, Proceedings of the National Academy of Sciences.

[28]  F. Martinon,et al.  BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. , 2009, Molecular cell.

[29]  B. Neel,et al.  Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress , 2009, Diabetes.

[30]  M. Tremblay,et al.  Regulation of the Met Receptor-tyrosine Kinase by the Protein-tyrosine Phosphatase 1B and T-cell Phosphatase* , 2008, Journal of Biological Chemistry.

[31]  A. Trusina,et al.  Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions , 2008, Cell.

[32]  R. Kaufman,et al.  Antioxidants reduce endoplasmic reticulum stress and improve protein secretion , 2008, Proceedings of the National Academy of Sciences.

[33]  J. Hoseki,et al.  ERdj5 Is Required as a Disulfide Reductase for Degradation of Misfolded Proteins in the ER , 2008, Science.

[34]  J. Keaney,et al.  Regulation of ROS signal transduction by NADPH oxidase 4 localization , 2008, The Journal of cell biology.

[35]  Yan Xu,et al.  ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. , 2008, Molecular biology of the cell.

[36]  Christian Appenzeller‐Herzog,et al.  The human PDI family: versatility packed into a single fold. , 2008, Biochimica et biophysica acta.

[37]  Zheng Wang,et al.  The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation. , 2008, Cancer research.

[38]  Hiderou Yoshida,et al.  Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. , 2007, Developmental cell.

[39]  P. Walter,et al.  Signal integration in the endoplasmic reticulum unfolded protein response , 2007, Nature Reviews Molecular Cell Biology.

[40]  W. Cai,et al.  High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. , 2007, Cancer letters.

[41]  K. Mori,et al.  Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress , 2006, Molecular and Cellular Biology.

[42]  T. Kietzmann,et al.  The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control. , 2006, Antioxidants & redox signaling.

[43]  S. Korsmeyer,et al.  Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α , 2006, Science.

[44]  John Calvin Reed,et al.  Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Hiderou Yoshida,et al.  pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response , 2006, The Journal of cell biology.

[46]  Veena Sangwan,et al.  Protein-tyrosine Phosphatase 1B Deficiency Protects against Fas-induced Hepatic Failure* , 2006, Journal of Biological Chemistry.

[47]  R. Khosravi‐Far,et al.  Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family. , 2005, Molecular phylogenetics and evolution.

[48]  J. Cheville,et al.  AGR2, an androgen‐inducible secretory protein overexpressed in prostate cancer , 2005, Genes, chromosomes & cancer.

[49]  Dong Liu,et al.  Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas. , 2005, Cancer research.

[50]  K. Mikoshiba,et al.  Subtype-Specific and ER Lumenal Environment-Dependent Regulation of Inositol 1,4,5-Trisphosphate Receptor Type 1 by ERp44 , 2005, Cell.

[51]  E. Chevet,et al.  Protein-tyrosine Phosphatase 1B Potentiates IRE1 Signaling during Endoplasmic Reticulum Stress* , 2004, Journal of Biological Chemistry.

[52]  A. Cooper,et al.  Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. , 2004, Molecular cell.

[53]  R. Kaufman,et al.  Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. , 2004, Journal of biochemistry.

[54]  Masayuki Yamamoto,et al.  Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 , 2004, Molecular and Cellular Biology.

[55]  J. Alan Diehl,et al.  PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress* , 2004, Journal of Biological Chemistry.

[56]  R. Glockshuber,et al.  ERp57 Is a Multifunctional Thiol-Disulfide Oxidoreductase* , 2004, Journal of Biological Chemistry.

[57]  G. Kozlov,et al.  Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two‐hybrid system , 2004, The EMBO journal.

[58]  Taiji Kimura,et al.  Different Contributions of the Three CXXC Motifs of Human Protein-disulfide Isomerase-related Protein to Isomerase Activity and Oxidative Refolding* , 2004, Journal of Biological Chemistry.

[59]  L. Glimcher,et al.  XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response , 2003, Molecular and Cellular Biology.

[60]  S. Camerini,et al.  Thiol‐mediated protein retention in the endoplasmic reticulum: the role of ERp44 , 2003, The EMBO journal.

[61]  Randal J. Kaufman,et al.  Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival , 2003, Molecular and Cellular Biology.

[62]  M. Howard,et al.  Functional Characterization of ERp18, a New Endoplasmic Reticulum-located Thioredoxin Superfamily Member* , 2003, Journal of Biological Chemistry.

[63]  M. Gorospe,et al.  P58IPK, a Novel Endoplasmic Reticulum Stress-inducible Protein and Potential Negative Regulator of eIF2α Signaling* , 2003, The Journal of Biological Chemistry.

[64]  T. Finkel.  Oxidant signals and oxidative stress. , 2003, Current opinion in cell biology.

[65]  R. Paules,et al.  An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. , 2003, Molecular cell.

[66]  Hiderou Yoshida,et al.  A time-dependent phase shift in the mammalian unfolded protein response. , 2003, Developmental cell.

[67]  Roberto Sitia,et al.  ERdj5, an Endoplasmic Reticulum (ER)-resident Protein Containing DnaJ and Thioredoxin Domains, Is Expressed in Secretory Cells or following ER Stress* , 2003, The Journal of Biological Chemistry.

[68]  L. Neckers,et al.  Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α , 2002, Molecular and Cellular Biology.

[69]  M. Katze,et al.  Control of PERK eIF2α kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Xi Chen,et al.  ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. , 2002, Developmental cell.

[71]  Kiyoshi Inoue,et al.  ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. , 2002, Genes & development.

[72]  Ron Prywes,et al.  The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi* , 2002, The Journal of Biological Chemistry.

[73]  M. Alessio,et al.  ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family , 2002, The EMBO journal.

[74]  K. Mori,et al.  XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor , 2001, Cell.

[75]  I. Braakman,et al.  Manipulation of oxidative protein folding and PDI redox state in mammalian cells , 2001, The EMBO journal.

[76]  A. Choi,et al.  Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein , 2001, The Journal of Biological Chemistry.

[77]  P. Walter,et al.  Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. , 2001, Current opinion in cell biology.

[78]  D. Ron,et al.  Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α , 2001, The Journal of cell biology.

[79]  M. Tohyama,et al.  Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress* , 2001, The Journal of Biological Chemistry.

[80]  X. Chen,et al.  ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.

[81]  D. Harrison,et al.  Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. , 2000, Circulation research.

[82]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[83]  M. Schapira,et al.  Regulated translation initiation controls stress-induced gene expression in mammalian cells. , 2000, Molecular cell.

[84]  N. Bulleid,et al.  Endoplasmic Reticulum Oxidoreductin 1-Lβ (ERO1-Lβ), a Human Gene Induced in the Course of the Unfolded Protein Response* 210 , 2000, The Journal of Biological Chemistry.

[85]  Anne Bertolotti,et al.  Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response , 2000, Nature Cell Biology.

[86]  M. Rocchi,et al.  ERO1-L, a Human Protein That Favors Disulfide Bond Formation in the Endoplasmic Reticulum* , 2000, The Journal of Biological Chemistry.

[87]  F. Urano,et al.  Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. , 2000, Science.

[88]  A Helenius,et al.  Setting the standards: quality control in the secretory pathway. , 1999, Science.

[89]  K. Mori,et al.  Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. , 1999, Molecular biology of the cell.

[90]  H. Söling,et al.  The protein disulphide-isomerase family: unravelling a string of folds. , 1999, The Biochemical journal.

[91]  S. Hirohashi,et al.  Cloning of the gene gob-4, which is expressed in intestinal goblet cells in mice. , 1999, Biochimica et biophysica acta.

[92]  D. Ron,et al.  Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase , 1999, Nature.

[93]  Hiderou Yoshida,et al.  Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins , 1998, The Journal of Biological Chemistry.

[94]  K. Miyazono,et al.  ASK1 is essential for JNK/SAPK activation by TRAF2. , 1998, Molecular cell.

[95]  Kohei Miyazono,et al.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.

[96]  D. Barford,et al.  Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography* , 1998, The Journal of Biological Chemistry.

[97]  M. Mann,et al.  ER‐60, a chaperone with thiol‐dependent reductase activity involved in MHC class I assembly , 1998, The EMBO journal.

[98]  Xiaozhong Wang,et al.  CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. , 1998, Genes & development.

[99]  David Y. Thomas,et al.  Enhanced Catalysis of Ribonuclease B Folding by the Interaction of Calnexin or Calreticulin with ERp57* , 1998, The Journal of Biological Chemistry.

[100]  K. Itoh,et al.  An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.

[101]  A. Palotie,et al.  Structures of the human gene for the protein disulfide isomerase-related polypeptide ERp60 and a processed gene and assignment of these genes to 15q15 and 1q21. , 1997, Genomics.

[102]  S. High,et al.  Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins , 1997, Science.

[103]  Minoru Takagi,et al.  Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways , 1997, Science.

[104]  A. Jaiswal,et al.  Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[105]  J. Olefsky,et al.  Protein Tyrosine Phosphatase 1B Interacts With the Activated Insulin Receptor , 1996, Diabetes.

[106]  B. Martin,et al.  cDNA cloning and baculovirus expression of the human liver endoplasmic reticulum P58: characterization as a protein disulfide isomerase isoform, but not as a protease or a carnitine acyltransferase. , 1995, Archives of biochemistry and biophysics.

[107]  M. Kikuchi,et al.  Molecular cloning of the cDNA encoding a novel protein disulfide isomerase‐related protein (PDIR) , 1995, FEBS letters.

[108]  Y. Kan,et al.  Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[109]  J. Sambrook,et al.  A transmembrane protein with a cdc2+ CDC28 -related kinase activity is required for signaling from the ER to the nucleus , 1993, Cell.

[110]  Peter Walter,et al.  Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase , 1993, Cell.

[111]  A J Sinskey,et al.  Oxidized redox state of glutathione in the endoplasmic reticulum. , 1992, Science.

[112]  H. Weintraub,et al.  Progressive determination during formation of the anteroposterior axis in Xenopus laevis , 1989, Cell.

[113]  W. Rutter,et al.  Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin , 1985, Nature.

[114]  C. Epstein,et al.  Acceleration of reactivation of reduced bovine pancreatic ribonuclease by a microsomal system from rat liver. , 1963, The Journal of biological chemistry.

[115]  K. Mori,et al.  Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus. , 2011, Cell structure and function.

[116]  A. Passaniti,et al.  ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer. , 2010, Cancer research.

[117]  K. Mori,et al.  pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation. , 2009, Cell structure and function.

[118]  A. Harada,et al.  ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum. , 2008, Cell structure and function.

[119]  P. Rudland,et al.  Increased expression of anterior gradient-2 is significantly associated with poor survival of prostate cancer patients , 2007, Prostate Cancer and Prostatic Diseases.

[120]  K. Mori,et al.  Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. , 2006, Cell structure and function.

[121]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.

[122]  H. Lodish.  Molecular Cell Biology , 1986 .