Excitatory effects of GABA in established brain networks

Although GABA remains the predominant inhibitory neurotransmitter of the brain, there are numerous recent examples of excitatory actions of GABA. These actions can be classified in two broad categories: phasic excitatory effects, as follow single activation of GABAergic afferents, and sustained excitatory effects, as follow prolonged activation of GABA(A) receptors. Evidence reviewed here indicates that, contrary to common belief, these effects are not restricted to embryonic or neonatal preparations.

[1]  G. Stuart,et al.  Excitatory Actions of GABA in the Cortex , 2003, Neuron.

[2]  M. Segal.  GABA induces a unique rise of [CA]i in cultured rat hippocampal neurons , 1993, Hippocampus.

[3]  A. Marty,et al.  Osmotic Tension as a Possible Link between GABAA Receptor Activation and Intracellular Calcium Elevation , 2004, Neuron.

[4]  R. Miles,et al.  On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro , 2002, Science.

[5]  J. Voipio,et al.  GABAergic excitation and K(+)-mediated volume transmission in the hippocampus. , 2000, Progress in brain research.

[6]  R. Miles,et al.  Mesial temporal lobe epilepsy: A pathological replay of developmental mechanisms? , 2003, Biology of the cell.

[7]  E. Delpire.  Cation-Chloride Cotransporters in Neuronal Communication. , 2000, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[8]  B. Gähwiler,et al.  Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro. , 1989, Journal of neurophysiology.

[9]  Arnold R. Kriegstein,et al.  Is there more to gaba than synaptic inhibition? , 2002, Nature Reviews Neuroscience.

[10]  Y. Isomura,et al.  Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons. , 2003, Journal of neurophysiology.

[11]  A. N. van den Pol,et al.  GABA-dependent firing of glutamate-evoked action potentials at AMPA/kainate receptors in developing hypothalamic neurons. , 1998, Journal of neurophysiology.

[12]  M. Poo,et al.  Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity , 2003, Neuron.

[13]  S. Royer,et al.  Cell-type-specific GABA responses and chloride homeostasis in the cortex and amygdala. , 2001, Journal of neurophysiology.

[14]  J. Voipio,et al.  Two developmental switches in GABAergic signalling: the K+–Cl− cotransporter KCC2 and carbonic anhydrase CAVII , 2005, The Journal of physiology.

[15]  T. Yoshioka,et al.  Developmental and circadian changes in Ca2+ mobilization mediated by GABAA and NMDA receptors in the suprachiasmatic nucleus , 2003, The European journal of neuroscience.

[16]  R. Sah,et al.  γ‐Aminobutyric acidA neurotransmission and cerebral ischemia , 2001 .

[17]  M B Jackson,et al.  GABAA receptor activation and the excitability of nerve terminals in the rat posterior pituitary. , 1995, The Journal of physiology.

[18]  A. Bordey,et al.  GABA Depolarizes Neuronal Progenitors of the Postnatal Subventricular Zone Via GABAA Receptor Activation , 2003, The Journal of physiology.

[19]  J. Connor,et al.  Depolarization- and transmitter-induced changes in intracellular Ca2+ of rat cerebellar granule cells in explant cultures , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[20]  Yosef Yarom,et al.  GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity , 1997, Nature.

[21]  J. Palva,et al.  Carbonic Anhydrase Isoform VII Acts as a Molecular Switch in the Development of Synchronous Gamma-Frequency Firing of Hippocampal CA1 Pyramidal Cells , 2004, The Journal of Neuroscience.

[22]  J. Voipio,et al.  Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance , 1987, Nature.

[23]  L. Nguyen,et al.  Autocrine/Paracrine Activation of the GABAA Receptor Inhibits the Proliferation of Neurogenic Polysialylated Neural Cell Adhesion Molecule-Positive (PSA-NCAM+) Precursor Cells from Postnatal Striatum , 2003, The Journal of Neuroscience.

[24]  A. Bordey,et al.  GABA Release and Uptake Regulate Neuronal Precursor Migration in the Postnatal Subventricular Zone , 2004, The Journal of Neuroscience.

[25]  Y. Ben-Ari.  Excitatory actions of gaba during development: the nature of the nurture , 2002, Nature Reviews Neuroscience.

[26]  K. Lamsa,et al.  Use-dependent shift from inhibitory to excitatory GABAA receptor action in SP-O interneurons in the rat hippocampal CA3 area. , 2003, Journal of neurophysiology.

[27]  Yves De Koninck,et al.  Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain , 2003, Nature.

[28]  M. Luskin,et al.  Neural progenitor cells of the neonatal rat anterior subventricular zone express functional GABA(A) receptors. , 2002, Journal of neurobiology.

[29]  J. A. Payne,et al.  Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 , 2004, The Journal of Neuroscience.

[30]  L. Trussell,et al.  Mixed excitatory and inhibitory GABA‐mediated transmission in chick cochlear nucleus , 2001, The Journal of physiology.

[31]  A. Marty,et al.  Coexistence of Excitatory and Inhibitory GABA Synapses in the Cerebellar Interneuron Network , 2003, The Journal of Neuroscience.