Preparation, in vitro bioactivity and drug release property of well-ordered mesoporous 58S bioactive glass

Bioactive glasses (BG) have proved to be able to chemically bond to living bone due to the formation of an apatite-like layer on its surface. In this paper, well-ordered mesoporous 58S bioactive glass (M58S) was synthesized in aqueous solution by a two-step acid-catalyzed self-assembly process combined with hydrothermal treatment. The drug release behavior of the M58S was investigated in phosphate buffered saline (PBS) at 37.5 °C for 20 days, and the assessment of in vitro bioactivity of M58S powders was carried out in simulated body fluid (SBF) at 37.5 °C. The results showed that M58S possessed good drug release behavior due to its well-ordered mesoporous structure, and a higher ability to induce hydroxyapatite formation in SBF. Therefore, well-ordered mesoporous bioactive glasses might be used as a bioactive drug release system for preparation of bone implant materials.

[1]  David R. Pichora,et al.  A mechanistic study of antibiotic release from biodegradable poly(d,1-lactide) cylinders , 1994 .

[2]  J. Devoisselle,et al.  Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[4]  M. Vallet‐Regí,et al.  A New Property of MCM-41: Drug Delivery System , 2001 .

[5]  T Kitsugi,et al.  Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. , 1990, Journal of Biomedical Materials Research.

[6]  T. Peltola,et al.  Calcium phosphate formation on porous sol-gel-derived SiO2 and CaO-P2O5-SiO2 substrates in vitro. , 1999, Journal of biomedical materials research.

[7]  L L Hench,et al.  An investigation of bioactive glass powders by sol-gel processing. , 1991, Journal of applied biomaterials : an official journal of the Society for Biomaterials.

[8]  Xufeng Zhou,et al.  Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities. , 2004, Angewandte Chemie.

[9]  Fredrickson,et al.  Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores , 1998, Science.

[10]  Larry L. Hench,et al.  Bonding mechanisms at the interface of ceramic prosthetic materials , 1971 .

[11]  M. Vallet‐Regí,et al.  Bioactivity in ordered mesoporous materials , 2004 .

[12]  M. Vallet‐Regí,et al.  Glasses with Medical Applications , 2003 .

[13]  J. S. Beck,et al.  Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism , 1992, Nature.

[14]  A. Clark,et al.  Effect of Texture on the Rate of Hydroxyapatite Formation on Gel-Silica Surface , 1995 .

[15]  D. Pichora,et al.  Biodegradable Controlled Antibiotic Release Devices for Osteomyelitis: Optimization of Release Properties , 1994, The Journal of pharmacy and pharmacology.

[16]  M. Vallet‐Regí,et al.  New bioactive glass and changes in porosity during the growth of a carbonate hydroxyapatite layer on glass surfaces , 2000 .

[17]  D. Robinson,et al.  Comparison of new and existing spectrophotometric methods for the analysis of tobramycin and other aminoglycosides. , 1990, Journal of pharmaceutical sciences.

[18]  Mark E. Davis.  Ordered porous materials for emerging applications , 2002, Nature.