Structure and toxicity of AZA-59, an azaspiracid shellfish poisoning toxin produced by Azadinium poporum (Dinophyceae).
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Christian Zurhelle | U. Tillmann | J. Tebben | V. Trainer | B. Krock | Jonathan Deeds | J. Kilcoyne | I. Samdal | S. Sosa | A. Tubaro | Jan Tebben | Jane Kilcoyne
[1] C. Vale,et al. Targeting Chloride Ion Channels: New Insights into the Mechanism of Action of the Marine Toxin Azaspiracid. , 2021, Chemical research in toxicology.
[2] C. Vale,et al. Partial blockade of human voltage-dependent sodium channels by the marine toxins azaspiracids. , 2020, Chemical research in toxicology.
[3] U. Tillmann,et al. Temporal and spatial distribution of Azadinium species in the inland and coastal waters of the Pacific northwest in 2014-2018. , 2020, Harmful algae.
[4] U. Tillmann,et al. The effect of temperature and salinity on growth rate and azaspiracid cell quotas in two strains of Azadinium poporum (Dinophyceae) from Puget Sound, Washington State. , 2019, Harmful algae.
[5] J. Kilcoyne,et al. Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions , 2019, Marine drugs.
[6] C. Miles,et al. A Practical ELISA for Azaspiracids in Shellfish via Development of a New Plate-Coating Antigen. , 2019, Journal of agricultural and food chemistry.
[7] U. Tillmann,et al. Two novel azaspiracids from Azadinium poporum, and a comprehensive compilation of azaspiracids produced by Amphidomataceae, (Dinophyceae). , 2019, Harmful algae.
[8] U. Tillmann,et al. Sympatric occurrence of two Azadinium poporum ribotypes in the Eastern Mediterranean Sea. , 2018, Harmful algae.
[9] C. Vale,et al. In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development. , 2018, ACS chemical neuroscience.
[10] F. Rise,et al. Identification of 21,22-Dehydroazaspiracids in Mussels ( Mytilus edulis) and in Vitro Toxicity of Azaspiracid-26. , 2018, Journal of natural products.
[11] J. Kilcoyne,et al. Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, -2 and -3 in mice. , 2018, Toxicology letters.
[12] U. Tillmann,et al. Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA. , 2017, Harmful algae.
[13] U. Tillmann,et al. Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum , 2015, Marine drugs.
[14] C. Miles,et al. Development of an ELISA for the Detection of Azaspiracids. , 2015, Journal of agricultural and food chemistry.
[15] Natalia Vilariño,et al. In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. , 2014, Toxicon : official journal of the International Society on Toxinology.
[16] F. Rise,et al. Isolation, structure elucidation, relative LC-MS response, and in vitro toxicity of azaspiracids from the dinoflagellate Azadinium spinosum. , 2014, Journal of natural products.
[17] F. Rise,et al. Epimers of azaspiracids: Isolation, structural elucidation, relative LC-MS response, and in vitro toxicity of 37-epi-azaspiracid-1. , 2014, Chemical research in toxicology.
[18] N. Adams,et al. Diarrhetic Shellfish Toxins and Other Lipophilic Toxins of Human Health Concern in Washington State , 2013, Marine drugs.
[19] Xi-Ping Huang,et al. The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels , 2012 .
[20] M. Twiner,et al. Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid. , 2012, Chemical research in toxicology.
[21] C. Miles,et al. Improved isolation procedure for azaspiracids from shellfish, structural elucidation of azaspiracid-6, and stability studies. , 2012, Journal of agricultural and food chemistry.
[22] J. Kilcoyne,et al. Comparative effects of the marine algal toxins azaspiracid-1, -2, and -3 on Jurkat T lymphocyte cells. , 2012, Chemical research in toxicology.
[23] G. Rossini,et al. Azaspiracid-1 inhibits endocytosis of plasma membrane proteins in epithelial cells. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.
[24] K. James,et al. Azaspiracid poisoning (AZP) toxins in shellfish: toxicological and health considerations. , 2010, Toxicon : official journal of the International Society on Toxinology.
[25] J. Furrer. A robust, sensitive, and versatile HMBC experiment for rapid structure elucidation by NMR: IMPACT-HMBC. , 2010, Chemical communications.
[26] Masayuki Satake,et al. Proteomic response of human neuroblastoma cells to azaspiracid-1. , 2009, Journal of proteomics.
[27] A. Cembella,et al. Azadinium spinosum gen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins , 2009 .
[28] C. Vale,et al. Cytotoxic effect of azaspiracid‐2 and azaspiracid‐2‐methyl ester in cultured neurons: Involvement of the c‐Jun N‐terminal kinase , 2008, Journal of neuroscience research.
[29] K. Nicolaou,et al. Azaspiracid substituent at C1 is relevant to in vitro toxicity. , 2008, Chemical research in toxicology.
[30] M. Twiner,et al. Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts , 2008, Marine drugs.
[31] K. Nicolaou,et al. The c-Jun-N-Terminal Kinase is Involved in the Neurotoxic Effect of Azaspiracid-1 , 2007, Cellular Physiology and Biochemistry.
[32] K. Nicolaou,et al. Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. , 2007, Biochemical pharmacology.
[33] K. Nicolaou,et al. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. , 2007, Journal of medicinal chemistry.
[34] P. Hess,et al. Azaspiracid-1 alters the E-cadherin pool in epithelial cells. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[35] K. Nicolaou,et al. Structure toxicity relationships of synthetic azaspiracid-1 and analogs in mice , 2006 .
[36] N. Kulagina,et al. Azaspiracid-1 inhibits bioelectrical activity of spinal cord neuronal networks. , 2006, Toxicon : official journal of the International Society on Toxinology.
[37] M. Vieytes,et al. Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes. , 2005, Biochemical pharmacology.
[38] M. Satake,et al. Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines. , 2005, Toxicon : official journal of the International Society on Toxinology.
[39] M. Vieytes,et al. Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets. , 2002, Cellular signalling.
[40] M. Satake,et al. Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels. , 2002, Toxicon : official journal of the International Society on Toxinology.
[41] M. Satake,et al. Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. , 2000, Toxicon : official journal of the International Society on Toxinology.
[42] J. Silke,et al. Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. , 1999, Natural toxins (Print).
[43] J. Silke,et al. AZASPIRACID, A NEW MARINE TOXIN HAVING UNIQUE SPIRO RING ASSEMBLIES, ISOLATED FROM IRISH MUSSELS, MYTILUS EDULIS , 1998 .
[44] M. D. Keller,et al. MEDIA FOR THE CULTURE OF OCEANIC ULTRAPHYTOPLANKTON 1,2 , 1987 .
[45] J. Kilcoyne,et al. Azaspiracid toxins: toxicological profile , 2016 .
[46] J. Silke,et al. AZASPIRACIDS – Toxicological Evaluation, Test Methods and Identifcation of the Source Organisms (ASTOX II) , 2014 .
[47] J. Cravedi,et al. Marine biotoxins in shellfish - Azaspiracid group 1 Scientific Opinion of the Panel on Contaminants in the Food chain , 2008 .
[48] M. Satake,et al. Relative toxicity of dinophysistoxin-2 (DTX-2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice. , 2007, Toxicon : official journal of the International Society on Toxinology.