Structure and toxicity of AZA-59, an azaspiracid shellfish poisoning toxin produced by Azadinium poporum (Dinophyceae).

[1]  C. Vale,et al.  Targeting Chloride Ion Channels: New Insights into the Mechanism of Action of the Marine Toxin Azaspiracid. , 2021, Chemical research in toxicology.

[2]  C. Vale,et al.  Partial blockade of human voltage-dependent sodium channels by the marine toxins azaspiracids. , 2020, Chemical research in toxicology.

[3]  U. Tillmann,et al.  Temporal and spatial distribution of Azadinium species in the inland and coastal waters of the Pacific northwest in 2014-2018. , 2020, Harmful algae.

[4]  U. Tillmann,et al.  The effect of temperature and salinity on growth rate and azaspiracid cell quotas in two strains of Azadinium poporum (Dinophyceae) from Puget Sound, Washington State. , 2019, Harmful algae.

[5]  J. Kilcoyne,et al.  Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions , 2019, Marine drugs.

[6]  C. Miles,et al.  A Practical ELISA for Azaspiracids in Shellfish via Development of a New Plate-Coating Antigen. , 2019, Journal of agricultural and food chemistry.

[7]  U. Tillmann,et al.  Two novel azaspiracids from Azadinium poporum, and a comprehensive compilation of azaspiracids produced by Amphidomataceae, (Dinophyceae). , 2019, Harmful algae.

[8]  U. Tillmann,et al.  Sympatric occurrence of two Azadinium poporum ribotypes in the Eastern Mediterranean Sea. , 2018, Harmful algae.

[9]  C. Vale,et al.  In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development. , 2018, ACS chemical neuroscience.

[10]  F. Rise,et al.  Identification of 21,22-Dehydroazaspiracids in Mussels ( Mytilus edulis) and in Vitro Toxicity of Azaspiracid-26. , 2018, Journal of natural products.

[11]  J. Kilcoyne,et al.  Toxic equivalency factors (TEFs) after acute oral exposure of azaspiracid 1, -2 and -3 in mice. , 2018, Toxicology letters.

[12]  U. Tillmann,et al.  Identification of Azadinium species and a new azaspiracid from Azadinium poporum in Puget Sound, Washington State, USA. , 2017, Harmful algae.

[13]  U. Tillmann,et al.  Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum , 2015, Marine drugs.

[14]  C. Miles,et al.  Development of an ELISA for the Detection of Azaspiracids. , 2015, Journal of agricultural and food chemistry.

[15]  Natalia Vilariño,et al.  In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. , 2014, Toxicon : official journal of the International Society on Toxinology.

[16]  F. Rise,et al.  Isolation, structure elucidation, relative LC-MS response, and in vitro toxicity of azaspiracids from the dinoflagellate Azadinium spinosum. , 2014, Journal of natural products.

[17]  F. Rise,et al.  Epimers of azaspiracids: Isolation, structural elucidation, relative LC-MS response, and in vitro toxicity of 37-epi-azaspiracid-1. , 2014, Chemical research in toxicology.

[18]  N. Adams,et al.  Diarrhetic Shellfish Toxins and Other Lipophilic Toxins of Human Health Concern in Washington State , 2013, Marine drugs.

[19]  Xi-Ping Huang,et al.  The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels , 2012 .

[20]  M. Twiner,et al.  Induction of apoptosis pathways in several cell lines following exposure to the marine algal toxin azaspiracid. , 2012, Chemical research in toxicology.

[21]  C. Miles,et al.  Improved isolation procedure for azaspiracids from shellfish, structural elucidation of azaspiracid-6, and stability studies. , 2012, Journal of agricultural and food chemistry.

[22]  J. Kilcoyne,et al.  Comparative effects of the marine algal toxins azaspiracid-1, -2, and -3 on Jurkat T lymphocyte cells. , 2012, Chemical research in toxicology.

[23]  G. Rossini,et al.  Azaspiracid-1 inhibits endocytosis of plasma membrane proteins in epithelial cells. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[24]  K. James,et al.  Azaspiracid poisoning (AZP) toxins in shellfish: toxicological and health considerations. , 2010, Toxicon : official journal of the International Society on Toxinology.

[25]  J. Furrer A robust, sensitive, and versatile HMBC experiment for rapid structure elucidation by NMR: IMPACT-HMBC. , 2010, Chemical communications.

[26]  Masayuki Satake,et al.  Proteomic response of human neuroblastoma cells to azaspiracid-1. , 2009, Journal of proteomics.

[27]  A. Cembella,et al.  Azadinium spinosum gen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins , 2009 .

[28]  C. Vale,et al.  Cytotoxic effect of azaspiracid‐2 and azaspiracid‐2‐methyl ester in cultured neurons: Involvement of the c‐Jun N‐terminal kinase , 2008, Journal of neuroscience research.

[29]  K. Nicolaou,et al.  Azaspiracid substituent at C1 is relevant to in vitro toxicity. , 2008, Chemical research in toxicology.

[30]  M. Twiner,et al.  Azaspiracid Shellfish Poisoning: A Review on the Chemistry, Ecology, and Toxicology with an Emphasis on Human Health Impacts , 2008, Marine drugs.

[31]  K. Nicolaou,et al.  The c-Jun-N-Terminal Kinase is Involved in the Neurotoxic Effect of Azaspiracid-1 , 2007, Cellular Physiology and Biochemistry.

[32]  K. Nicolaou,et al.  Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. , 2007, Biochemical pharmacology.

[33]  K. Nicolaou,et al.  Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. , 2007, Journal of medicinal chemistry.

[34]  P. Hess,et al.  Azaspiracid-1 alters the E-cadherin pool in epithelial cells. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[35]  K. Nicolaou,et al.  Structure toxicity relationships of synthetic azaspiracid-1 and analogs in mice , 2006 .

[36]  N. Kulagina,et al.  Azaspiracid-1 inhibits bioelectrical activity of spinal cord neuronal networks. , 2006, Toxicon : official journal of the International Society on Toxinology.

[37]  M. Vieytes,et al.  Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes. , 2005, Biochemical pharmacology.

[38]  M. Satake,et al.  Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines. , 2005, Toxicon : official journal of the International Society on Toxinology.

[39]  M. Vieytes,et al.  Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets. , 2002, Cellular signalling.

[40]  M. Satake,et al.  Chronic effects in mice caused by oral administration of sublethal doses of azaspiracid, a new marine toxin isolated from mussels. , 2002, Toxicon : official journal of the International Society on Toxinology.

[41]  M. Satake,et al.  Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. , 2000, Toxicon : official journal of the International Society on Toxinology.

[42]  J. Silke,et al.  Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. , 1999, Natural toxins (Print).

[43]  J. Silke,et al.  AZASPIRACID, A NEW MARINE TOXIN HAVING UNIQUE SPIRO RING ASSEMBLIES, ISOLATED FROM IRISH MUSSELS, MYTILUS EDULIS , 1998 .

[44]  M. D. Keller,et al.  MEDIA FOR THE CULTURE OF OCEANIC ULTRAPHYTOPLANKTON 1,2 , 1987 .

[45]  J. Kilcoyne,et al.  Azaspiracid toxins: toxicological profile , 2016 .

[46]  J. Silke,et al.  AZASPIRACIDS – Toxicological Evaluation, Test Methods and Identifcation of the Source Organisms (ASTOX II) , 2014 .

[47]  J. Cravedi,et al.  Marine biotoxins in shellfish - Azaspiracid group 1 Scientific Opinion of the Panel on Contaminants in the Food chain , 2008 .

[48]  M. Satake,et al.  Relative toxicity of dinophysistoxin-2 (DTX-2) compared with okadaic acid, based on acute intraperitoneal toxicity in mice. , 2007, Toxicon : official journal of the International Society on Toxinology.