Murisolin: A New Cytotoxic Mono-tetrahydrofuran-g-lactone from Annona muricata

Using cytotoxicity as a bioassay guide led to the isolation of a new active acetogenin from the seed of Annona muricata. Murisolin, 1 is the first example of a mono-tetrahydrofuran-γ-lactone acetogenin with only three hydroxyl groups. Its structure was characterised by mass spectrometry and 2D homonuclear and heteronuclear correlations nmr spectroscopy. The relative stereochemistry of four of its six chiral centers was established bh 1 H-nmr comparative spectral studies between the murisolin triacetate and some bistetrahydrofuran acetogenin acetates