Which measures of obesity best predict cardiovascular risk?

“ The possible relationship between obesity and cardiovascular disease has been the subject of great controversy.” ([1][1]) In the 24 years since this statement was written, the contentiousness over the issue has evolved somewhat, but has not abated. Today, there is general acceptance that

[1]  R. Ross,et al.  Waist circumference and not body mass index explains obesity-related health risk 1 – 3 , 2004 .

[2]  J. Manson,et al.  A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women , 2005, The New England journal of medicine.

[3]  Simon Capewell,et al.  Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. , 2007, Journal of the American College of Cardiology.

[4]  M. Thun,et al.  The effect of age on the association between body-mass index and mortality. , 1998, The New England journal of medicine.

[5]  A. Folsom,et al.  Body Mass Index, Waist/Hip Ratio, and Coronary Heart Disease Incidence in African Americans and Whites , 1998 .

[6]  D Spiegelman,et al.  Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men. , 1995, American journal of epidemiology.

[7]  P. Zimmet,et al.  Expanding evidence for the multiple dangers of epidemic abdominal obesity. , 2008, Circulation.

[8]  N. Day,et al.  Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: results from the EPIC-Norfolk population-based cohort study. , 2006, Atherosclerosis.

[9]  Graham A. Colditz,et al.  Body weight and mortality among women , 1995 .

[10]  N. Day,et al.  Fat distribution, body mass index and blood pressure in 22 090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study , 2004, Journal of hypertension.

[11]  C. Lewis,et al.  Mortality and cardiac and vascular outcomes in extremely obese women. , 2006, JAMA.

[12]  J. Després,et al.  Abdominal obesity and metabolic syndrome , 2006, Nature.

[13]  K. Bailey,et al.  Recent trends in the prevalence of coronary disease: a population-based autopsy study of nonnatural deaths. , 2008, Archives of internal medicine.

[14]  B Rosner,et al.  A prospective study of postmenopausal estrogen therapy and coronary heart disease. , 1985, The New England journal of medicine.

[15]  S. Olshansky,et al.  A potential decline in life expectancy in the United States in the 21st century. , 2005, The New England journal of medicine.

[16]  Haskell Wl,et al.  Waist/hip ratio, body mass index and premature cardiovascular disease mortality in US Army veterans during a twenty-three year follow-up study. , 1992 .

[17]  T. Lakka,et al.  Abdominal obesity is associated with increased risk of acute coronary events in men. , 2002, European heart journal.

[18]  P. J. Larsen,et al.  Central and peripheral fat mass have contrasting effect on the progression of aortic calcification in postmenopausal women. , 2003, European heart journal.

[19]  J. Shaw,et al.  Waist circumference, waist–hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults , 2003, Journal of internal medicine.

[20]  Lauren Lissner,et al.  Hip circumference and cardiovascular morbidity and mortality in men and women. , 2004, Obesity research.

[21]  J Michael Gaziano,et al.  Measures of obesity and cardiovascular risk among men and women. , 2008, Journal of the American College of Cardiology.

[22]  C. Björkelund,et al.  Larger hip circumference independently predicts health and longevity in a Swedish female cohort. , 2001, Obesity research.

[23]  Iain Buchan,et al.  Body Fat Distribution and Risk of Coronary Heart Disease in Men and Women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk Cohort: A Population-Based Prospective Study , 2007, Circulation.

[24]  Frank B. Hu,et al.  Abdominal Obesity and the Risk of All-Cause, Cardiovascular, and Cancer Mortality: Sixteen Years of Follow-Up in US Women , 2008, Circulation.

[25]  K. Flegal,et al.  Prevalence of overweight and obesity in the United States, 1999-2004. , 2006, JAMA.

[26]  P. Wahl,et al.  Visceral adiposity and incident coronary heart disease in Japanese-American men. The 10-year follow-up results of the Seattle Japanese-American Community Diabetes Study. , 1999, Diabetes care.

[27]  K. Reynolds,et al.  Body weight and mortality among men and women in China. , 2006, JAMA.

[28]  S. Grundy,et al.  The metabolic syndrome , 2003, The Lancet.

[29]  E. Tuzcu,et al.  Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study). , 2006, The American journal of cardiology.

[30]  Sun Ha Jee,et al.  Body-mass index and mortality in Korean men and women. , 2006, The New England journal of medicine.

[31]  T. Sellers,et al.  Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. , 2000, Archives of internal medicine.

[32]  P. Björntorp,et al.  Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913. , 1984, British medical journal.

[33]  B. J. Gersh.  Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000 , 2008 .

[34]  G A Colditz,et al.  Abdominal adiposity and coronary heart disease in women. , 1998, JAMA.

[35]  M. Thun,et al.  Body-mass index and mortality in a prospective cohort of U.S. adults. , 1999, The New England journal of medicine.

[36]  A. Khera,et al.  The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study. , 2007, Journal of the American College of Cardiology.

[37]  Tim Byers,et al.  Overweight and mortality among baby boomers--now we're getting personal. , 2006, The New England journal of medicine.

[38]  R. Ross,et al.  Waist circumference and not body mass index explains obesity-related health risk. , 2004, The American journal of clinical nutrition.

[39]  Elizabeth Breeze,et al.  Weight, shape, and mortality risk in older persons: elevated waist-hip ratio, not high body mass index, is associated with a greater risk of death. , 2006, The American journal of clinical nutrition.

[40]  K. Pennert,et al.  Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. , 1984, British medical journal.

[41]  T. Harris,et al.  Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. , 2006, The New England journal of medicine.

[42]  R N Pierson,et al.  How useful is body mass index for comparison of body fatness across age, sex, and ethnic groups? , 1996, American journal of epidemiology.

[43]  J. Buring,et al.  Abdominal and total adiposity and risk of coronary heart disease in men , 2001, International Journal of Obesity.

[44]  Walter C Willett,et al.  Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women , 2006, Circulation.

[45]  S. Yusuf,et al.  Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study , 2005, The Lancet.

[46]  I-Min Lee,et al.  A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women , 2005 .

[47]  L. Pérusse,et al.  Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk factors: the Quebec Family Study. , 2001, The American journal of clinical nutrition.

[48]  Final report on the aspirin component of the ongoing Physicians' Health Study. , 1989, The New England journal of medicine.