Role of the EGF-CFC Family in Mammary Gland Development and Neoplasia

[1]  N. Normanno,et al.  Regulation of human cripto‐1 gene expression by TGF‐β1 and BMP‐4 in embryonal and colon cancer cells , 2008, Journal of cellular physiology.

[2]  N. Normanno,et al.  Regulation of Cripto-1 signaling and biological activity by caveolin-1 in mammary epithelial cells. , 2008, The American journal of pathology.

[3]  C. Bianco,et al.  Requirement of Glycosylphosphatidylinositol Anchor of Cripto-1 for trans Activity as a Nodal Co-receptor* , 2007, Journal of Biological Chemistry.

[4]  C. Ibáñez,et al.  Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. , 2007, Developmental biology.

[5]  W. Fischer,et al.  GRP78 and Cripto Form a Complex at the Cell Surface and Collaborate To Inhibit Transforming Growth Factor β Signaling and Enhance Cell Growth , 2007, Molecular and Cellular Biology.

[6]  C. Bianco,et al.  Growth Factor Induction of Cripto-1 Shedding by Glycosylphosphatidylinositol-Phospholipase D and Enhancement of Endothelial Cell Migration* , 2007, Journal of Biological Chemistry.

[7]  P. Stanley,et al.  The Threonine That Carries Fucose, but Not Fucose, Is Required for Cripto to Facilitate Nodal Signaling* , 2007, Journal of Biological Chemistry.

[8]  R. Rampal,et al.  Notch signaling in normal and disease States: possible therapies related to glycosylation. , 2007, Current molecular medicine.

[9]  M. Stockler,et al.  BS01
LOCALLY ADVANCED BREAST CANCER: NEED FOR A CO‐ORDINATED, MULTIDISCIPLINARY APPROACH , 2007 .

[10]  C. Kennedy,et al.  Overexpression of Cripto and its prognostic significance in breast cancer: a study with long-term survival. , 2007, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[11]  Amy S. Lee GRP78 induction in cancer: therapeutic and prognostic implications. , 2007, Cancer research.

[12]  C. Bianco,et al.  beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. , 2007, Biochemical and biophysical research communications.

[13]  M. Shen Nodal signaling: developmental roles and regulation , 2007, Development.

[14]  E. Yang,et al.  Anti-Cripto Mab inhibit tumour growth and overcome MDR in a human leukaemia MDR cell line by inhibition of Akt and activation of JNK/SAPK and bad death pathways , 2007, British Journal of Cancer.

[15]  W. Vale,et al.  Cripto Binds Transforming Growth Factor β (TGF-β) and Inhibits TGF-β Signaling , 2006, Molecular and Cellular Biology.

[16]  I. Tomlinson,et al.  Colorectal cancer and genetic alterations in the Wnt pathway , 2006, Oncogene.

[17]  C. Pedone,et al.  Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala. , 2006, Journal of medicinal chemistry.

[18]  I. Kurth,et al.  Germ Cell Nuclear Factor Is a Repressor of CRIPTO-1 and CRIPTO-3* , 2006, Journal of Biological Chemistry.

[19]  W. Vale,et al.  Cripto Binds Transforming Growth Factor β (TGF-β) and Inhibits TGF-β Signaling , 2006, Molecular and Cellular Biology.

[20]  J. Brickman,et al.  Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal. , 2006, Development.

[21]  G. D'aiuto,et al.  Identification of Cripto-1 as a Novel Serologic Marker for Breast and Colon Cancer , 2006, Clinical Cancer Research.

[22]  A. Chambery,et al.  Chemical synthesis of mouse cripto CFC variants , 2006, Proteins.

[23]  S. Groshen,et al.  GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. , 2006, Cancer research.

[24]  M. Hendrix,et al.  Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness , 2006, Nature Network Boston.

[25]  C. Hill,et al.  A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos. , 2006, Developmental biology.

[26]  Amy S. Lee,et al.  Stress induction of GRP78/BiP and its role in cancer. , 2006, Current molecular medicine.

[27]  M. Matzuk,et al.  The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo , 2005, Development.

[28]  W. Abdallah,et al.  Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo , 2005, Journal of Cell Science.

[29]  A. Ebert,et al.  Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma , 2005, Oncogene.

[30]  A. Nicholson,et al.  Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. , 2005, The American journal of pathology.

[31]  P. Xing,et al.  Cripto as a target for cancer immunotherapy , 2005, Expert opinion on therapeutic targets.

[32]  M. Asashima,et al.  Maternal Wnt11 Activates the Canonical Wnt Signaling Pathway Required for Axis Formation in Xenopus Embryos , 2005, Cell.

[33]  A. Ebert,et al.  Role of human cripto-1 in tumor angiogenesis. , 2005, Journal of the National Cancer Institute.

[34]  N. Normanno,et al.  Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV‐Cripto‐1 transgenic mice , 2004, Journal of cellular physiology.

[35]  N. Normanno,et al.  CRIPTO-1: a novel target for therapeutic intervention in human carcinoma. , 2004, International journal of oncology.

[36]  Shuji Takahashi,et al.  Xantivin suppresses the activity of EGF-CFC genes to regulate nodal signaling. , 2004, The International journal of developmental biology.

[37]  G. Pietersz,et al.  Cripto: a novel target for antibody-based cancer immunotherapy. , 2004, Cancer research.

[38]  Michael M Shen,et al.  Two Modes by which Lefty Proteins Inhibit Nodal Signaling , 2004, Current Biology.

[39]  C. Bianco,et al.  Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis. , 2004, The American journal of pathology.

[40]  H. Adkins,et al.  Nodal and Cripto-1: Embryonic Pattern Formation Genes Involved in Mammary Gland Development and Tumorigenesis , 2004, Journal of Mammary Gland Biology and Neoplasia.

[41]  T. Lepage,et al.  Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo. , 2004, Developmental cell.

[42]  Alexander F Schier,et al.  Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors , 2004, PLoS biology.

[43]  R. Kalluri,et al.  The role of epithelial-to-mesenchymal transition in renal fibrosis , 2004, Journal of Molecular Medicine.

[44]  N. Normanno,et al.  Cripto‐1 overexpression leads to enhanced invasiveness and resistance to anoikis in human MCF‐7 breast cancer cells , 2004, Journal of cellular physiology.

[45]  Hans Clevers,et al.  β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation , 2003, Development.

[46]  A. Schier Nodal signaling in vertebrate development. , 2003, Annual review of cell and developmental biology.

[47]  Chenbei Chang,et al.  Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto. , 2003, Genes & development.

[48]  E. Adamson,et al.  Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells , 2003, The Journal of cell biology.

[49]  D. Kane,et al.  One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling. , 2003, Developmental biology.

[50]  H. V. van Vlijmen,et al.  The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis. , 2003, European journal of biochemistry.

[51]  Mohammad Zafari,et al.  Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. , 2003, The Journal of clinical investigation.

[52]  Y. Saijoh,et al.  Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. , 2003, Genes & development.

[53]  Y. Saijoh,et al.  Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate , 2003, Development.

[54]  W. Vale,et al.  Cripto forms a complex with activin and type II activin receptors and can block activin signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  N. Normanno,et al.  A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src. , 2003, Cancer research.

[56]  F. Fagotto,et al.  The ins and outs of APC and β‐catenin nuclear transport , 2002 .

[57]  R. Cardiff,et al.  Activation of different Wnt/β-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors , 2002, Oncogene.

[58]  M. Shen,et al.  Dual Roles of Cripto as a Ligand and Coreceptor in the Nodal Signaling Pathway , 2002, Molecular and Cellular Biology.

[59]  J. Thiery Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.

[60]  A. Schier,et al.  A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects , 2002, Human Genetics.

[61]  A. Ebert,et al.  Cripto-1 Activates Nodal- and ALK4-Dependent and -Independent Signaling Pathways in Mammary Epithelial Cells , 2002, Molecular and Cellular Biology.

[62]  R. Cardiff,et al.  Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[63]  N. Normanno,et al.  Detection and localization of Cripto‐1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin–cripto‐1 fusion protein † , 2002, Journal of cellular physiology.

[64]  G. Manco,et al.  Structure-function analysis of the EGF-CFC family member Cripto identifies residues essential for nodal signalling. , 2001, Development.

[65]  B. Damon,et al.  Fucosylation of Cripto is required for its ability to facilitate nodal signaling. , 2001, Journal of Biological Chemistry.

[66]  A. Brivanlou,et al.  The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development. , 2001, Genes & development.

[67]  L. Attisano,et al.  The transcriptional role of Smads and FAST (FoxH1) in TGFβ and activin signalling , 2001, Molecular and Cellular Endocrinology.

[68]  T. Schlange,et al.  Chick CFC controls Lefty1 expression in the embryonic midline and nodal expression in the lateral plate. , 2001, Developmental biology.

[69]  M. Whitman,et al.  Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. , 2001, Molecular cell.

[70]  A. Ebert,et al.  Identification of Cripto-1 in human milk , 2001, Breast Cancer Research and Treatment.

[71]  K. Williams,et al.  The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer. , 2000, Endocrine-related cancer.

[72]  A. Casamassimi,et al.  Simultaneous blockade of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts , 2000, Oncogene.

[73]  Alexander F. Schier,et al.  Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects , 2000, Nature Genetics.

[74]  G. Schoenwolf,et al.  Subtractive hybridization identifies chick-cripto, a novel EGF-CFC ortholog expressed during gastrulation, neurulation and early cardiogenesis. , 2000, Gene.

[75]  P. Polakis Wnt signaling and cancer. , 2000, Genes & development.

[76]  A. Schier,et al.  The EGF-CFC gene family in vertebrate development. , 2000, Trends in genetics : TIG.

[77]  D. Barnes,et al.  Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. , 2000, Cancer research.

[78]  A. Casamassimi,et al.  EGF-related antisense oligonucleotides inhibit the proliferation of human ovarian carcinoma cells. , 2000, Annals of oncology : official journal of the European Society for Medical Oncology.

[79]  E. Adamson,et al.  Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development , 2000, Mechanisms of Development.

[80]  A. Schier,et al.  Nodal signalling in vertebrate development , 2000, Nature.

[81]  M. Kasuga,et al.  A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells. , 1999, Biochemical and biophysical research communications.

[82]  C. Birchmeier,et al.  A role of the cryptic gene in the correct establishment of the left–right axis , 1999, Current Biology.

[83]  W. Talbot,et al.  Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. , 1999, Genes & development.

[84]  A. Ebert,et al.  Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in human cervical carcinoma cells. , 1999, Cancer research.

[85]  W. Talbot,et al.  The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling , 1999, Cell.

[86]  A. Ebert,et al.  Cripto-1 Indirectly Stimulates the Tyrosine Phosphorylation oferb B-4 through a Novel Receptor* , 1999, The Journal of Biological Chemistry.

[87]  A. Casamassimi,et al.  EGF‐related peptides are involved in the proliferation and survival of MDA‐MB‐468 human breast carcinoma cells , 1999, International journal of cancer.

[88]  E. Adamson,et al.  Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. , 1999, Development.

[89]  A. Wynshaw-Boris,et al.  Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo , 1998, Nature.

[90]  Alexander F. Schier,et al.  Positional Cloning Identifies Zebrafish one-eyed pinhead as a Permissive EGF-Related Ligand Required during Gastrulation , 1998, Cell.

[91]  C. Bianco,et al.  Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and phosphatidylinositol 3'-kinase-dependent pathway. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[92]  M. Sternberg,et al.  Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto. , 1997, Biochemistry.

[93]  P. Leder,et al.  A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. , 1997, Development.

[94]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[95]  N. Normanno,et al.  Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[96]  M. Merino,et al.  Differential immunohistochemical detection of transforming growth factor α, amphiregulin and CRIPTO in human normal and malignant breast tissues , 1996, International journal of cancer.

[97]  A. Harris,et al.  Expression of messenger RNA for amphiregulin, heregulin, and cripto-1, three new members of the epidermal growth factor family, in human breast carcinomas , 1995, Breast Cancer Research and Treatment.

[98]  L. Bobrow,et al.  Amphiregulin and cripto overexpression in breast-cancer - relationship with prognosis and clinical and molecular-variables. , 1995, International journal of oncology.

[99]  D. Salomon,et al.  Detection and location of amphiregulin and Cripto‐1 expression in the developing postnatal mouse mammary gland , 1995, Molecular reproduction and development.

[100]  Susan E. Johnson,et al.  Expression of epidermal growth factor family gene members in early mouse development , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[101]  N. Normanno,et al.  Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. , 1994, The Journal of biological chemistry.

[102]  G. Merlo,et al.  Expression of transforming growth factor alpha, amphiregulin and cripto-1 in human breast carcinomas. , 1994, British Journal of Cancer.

[103]  A. Simeone,et al.  The murine cripto gene: expression during mesoderm induction and early heart morphogenesis. , 1993, Development.

[104]  A. Mazar,et al.  Structural requirements for the growth factor activity of the amino-terminal domain of urokinase. , 1992, The Journal of biological chemistry.

[105]  D. Salomon,et al.  Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line. , 1991, Cancer research.

[106]  Silvana,et al.  Molecular characterization of a gene of the ‘EGF family’ expressed in undifferentiated human NTERA2 teratocarcinoma cells. , 1989, The EMBO journal.

[107]  N. Normanno,et al.  Cripto-1: an oncofetal gene with many faces. , 2005, Current topics in developmental biology.

[108]  D. Chopin,et al.  Epithelial Cell Plasticity in Development and Tumor Progression , 2004, Cancer and Metastasis Reviews.

[109]  Youhua Liu Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. , 2004, Journal of the American Society of Nephrology : JASN.

[110]  A. Schier,et al.  EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1 , 2003 .

[111]  W. Talbot,et al.  Nodal signaling and the zebrafish organizer. , 2001, The International journal of developmental biology.

[112]  Y. Saijoh,et al.  Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. , 2000, Molecular cell.

[113]  M. Desantis,et al.  Purification and characterization of a recombinant human cripto-1 protein. , 1998, Growth factors.