Snoring as a risk factor for ischaemic heart disease and stroke in men.

The association of snoring with ischaemic heart disease and stroke was studied prospectively in 4388 men aged 40-69. The men were asked, in a questionnaire sent to them, whether they snored habitually, frequently, occasionally, or never. Hospital records and death certificates were checked for the next three years to establish how many of the men developed ischaemic heart disease or stroke: the numbers were 149 and 42, respectively. Three categories of snoring were used for analysis: habitual and frequent snorers (n = 1294), occasional snorers (n = 2614), and non-snorers (n = 480). The age adjusted relative risk of ischaemic heart disease between habitual plus frequent snorers and non-snorers was 1.91 (p less than 0.01) and for ischaemic heart disease or stroke, or both, 2.38 (p less than 0.001). There were no cases of stroke among the non-snorers. Adjustment for age, body mass index, history of hypertension, smoking, and alcohol use did not significantly decrease the relative risks, which were 1.71 (p greater than 0.05) for ischaemic heart disease and 2.08 (p less than 0.01) for ischaemic heart disease and stroke combined. At the beginning of follow up in 1981, 462 men reported a history of angina pectoris or myocardial infarction. For them the relative risk of ischaemic heart disease between habitual plus frequent snorers and non-snorers was 1.30 (NS); for men without previous ischaemic heart disease 2.72 (p less than 0.05). Snoring seems to be a potential determinant of risk of ischaemic heart disease and stroke.

[1]  A. Reunanen,et al.  Validity of hospital discharge data in a prospective epidemiological study on stroke and myocardial infarction. , 2009, Acta medica Scandinavica.

[2]  R. Hirsch,et al.  EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON , 1987, The Lancet.

[3]  C. Guilleminault,et al.  Obstructive sleep apnea and cardiac index. , 1986, Chest.

[4]  M. Partinen,et al.  SNORING AND CEREBRAL INFARCTION , 1985, The Lancet.

[5]  E. Braunwald,et al.  Circadian variation in the frequency of onset of acute myocardial infarction. , 1985, The New England journal of medicine.

[6]  T. Bradley,et al.  Pathogenesis and pathophysiology of the obstructive sleep apnea syndrome. , 1985, The Medical clinics of North America.

[7]  E V Dunn,et al.  Snoring as a risk factor for disease: an epidemiological survey. , 1985, British medical journal.

[8]  J. Shepard,et al.  Relationship of ventricular ectopy to oxyhemoglobin desaturation in patients with obstructive sleep apnea. , 1985, Chest.

[9]  A. Gorin,et al.  Undiagnosed sleep apnea in patients with essential hypertension. , 1985, Annals of internal medicine.

[10]  J. Kaprio,et al.  SNORING AS A RISK FACTOR FOR HYPERTENSION AND ANGINA PECTORIS , 1985, The Lancet.

[11]  E. Bixler,et al.  SLEEP APNOEA IN A HYPERTENSIVE POPULATION , 1984, The Lancet.

[12]  P Lavie,et al.  Prevalence of sleep apnea syndrome among patients with essential hypertension. , 1984, American heart journal.

[13]  C. Currie,et al.  The Joint Geriatric Orthopaedic Service in South Edinburgh: November 1979-October 1980. , 1984, Health bulletin.

[14]  M. Brown,et al.  Regulation of plasma cholesterol by lipoprotein receptors. , 1981, Science.

[15]  F. Cirignotta,et al.  Some epidemiological data on snoring and cardiocirculatory disturbances. , 1980, Sleep.

[16]  D. Kupfer,et al.  Polycythaemia vera and central sleep apnoea. , 1980, British medical journal.

[17]  S. Swiryn,et al.  Nocturnal atrioventricular block as a manifestation of sleep apnea syndrome. , 1979, Chest.

[18]  G. M. Mead,et al.  Survival and death from subdural haematoma on medical wards. , 1977, Postgraduate medical journal.

[19]  J. Kaprio,et al.  Alcohol-related diseases associated with ischaemic heart disease: a three-year follow-up of middle-aged male hospital patients. , 1986, Alcohol and Alcoholism.

[20]  C. Guilleminault,et al.  Cardiac dysfunction during sleep. , 1985, Annals of clinical research.

[21]  D. Ingbar,et al.  Pathophysiology and treatment of sleep apnea. , 1985, Annual review of medicine.

[22]  C. Guilleminault,et al.  Sleep/Wake Disorders: Natural History, Epidemiology, and Long-Term Evolution. , 1984 .

[23]  W. Dixon,et al.  BMDP statistical software , 1983 .

[24]  J. Kaprio,et al.  Differences in mortality from ischemic heart disease by marital status and social class. , 1980, Journal of chronic diseases.

[25]  W C Dement,et al.  The sleep apnea syndromes. , 1976, Annual review of medicine.