Non-invasive Raman signal enhancement in a scattering medium

In order to enhance spontaneous Raman signals, we exploit non-invasive wavefront shaping methods using a spectrally resolved speckle variance optimization algorithm. We demonstrate unprecedented signal enhancement > 5x in an epi-geometry.

[1]  W. Marsden.  I and J , 2012 .

[2]  P. Matousek,et al.  Smart Gold Nanostructures for Light Mediated Cancer Theranostics: Combining Optical Diagnostics with Photothermal Therapy , 2020, Advanced science.

[3]  Y. Silberberg,et al.  Light focusing through scattering media via linear fluorescence variance maximization, and its application for fluorescence imaging. , 2019, Optics express.

[4]  K. Dholakia,et al.  Raman imaging through a single multimode fibre. , 2017, Optics express.

[5]  A. Mosk,et al.  Focusing coherent light through opaque strongly scattering media. , 2007, Optics letters.

[6]  Cuong Dang,et al.  Non-invasive optical focusing inside strongly scattering media with linear fluorescence , 2020, 2002.01260.

[7]  O. Katz,et al.  Noninvasive nonlinear focusing and imaging through strongly scattering turbid layers , 2014, 1405.4826.

[8]  Lyubov V. Amitonova,et al.  Sensitivity analysis of Raman endoscopy with and without wavefront shaping. , 2020, Optics express.

[9]  Graham A Throckmorton,et al.  Wavefront shaping enhanced Raman scattering in a turbid medium. , 2016, Optics letters.

[10]  J. Bertolotti,et al.  Enhanced deep detection of Raman scattered light by wavefront shaping. , 2018, Optics express.

[11]  Jonathan Dong,et al.  Noninvasive light focusing in scattering media using speckle variance optimization , 2019, Optica.

[12]  Changhuei Yang,et al.  Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue , 2015, Nature Photonics.

[13]  Tomáš Čižmár,et al.  Label-free CARS microscopy through a multimode fiber endoscope. , 2019, Optics express.

[14]  S. Popoff,et al.  Measuring the transmission matrix in optics: an approach to the study and control of light propagation in disordered media. , 2009, Physical review letters.

[15]  X. Xie,et al.  Adaptive optics for enhanced signal in CARS microscopy. , 2007, Optics express.