A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival
暂无分享,去创建一个
L. Studer | T. Evans | Shuibing Chen | E. Apostolou | Tuo Zhang | Sadaf Amin | Ting Zhou | Zaniar Ghazizadeh | Miguel Crespo | J. Xiang | Hui Zeng | M. Guo | Lei Tan | Suranjit Mukherjee | Christopher L. Robinson | Hui Wang | C. N. Chong | T. Kim | Zohreh Sadat Badieyan | Reyn M. Kenyon
[1] R. Valdiserri. Epidemic. , 2020, Health affairs.
[2] Albert S. Yu,et al. An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. , 2016, Cell stem cell.
[3] R. Passier,et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells , 2015, Nature Biotechnology.
[4] L. Groop,et al. Genetics of Type 2 Diabetes—Pitfalls and Possibilities , 2015, Genes.
[5] James D. Johnson,et al. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells , 2014, Nature Biotechnology.
[6] Neville E. Sanjana,et al. Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.
[7] M. McCarthy,et al. Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study , 2014, PLoS medicine.
[8] Tanya M. Teslovich,et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility , 2014 .
[9] J. Bodin,et al. Transmaternal bisphenol A exposure accelerates diabetes type 1 development in NOD mice. , 2014, Toxicological sciences : an official journal of the Society of Toxicology.
[10] Kari Stefansson,et al. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes , 2014, Nature Genetics.
[11] Neville E. Sanjana,et al. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells , 2014, Science.
[12] M. Saadat. Null genotypes of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms increased susceptibility to type 2 diabetes mellitus, a meta-analysis. , 2013, Gene.
[13] John R. Yates,et al. Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription , 2013, Cell.
[14] C. Ulhoa,et al. Evaluation of Glutathione S-Transferase GSTM1 and GSTT1 Deletion Polymorphisms on Type-2 Diabetes Mellitus Risk , 2013, PloS one.
[15] O. Surova,et al. Various modes of cell death induced by DNA damage , 2013, Oncogene.
[16] Halit Ongen,et al. Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome , 2013, Genome research.
[17] J. Bodin,et al. Long-term bisphenol A exposure accelerates insulitis development in diabetes-prone NOD mice , 2013, Immunopharmacology and immunotoxicology.
[18] Cole Trapnell,et al. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.
[19] Hongyi Yan,et al. Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis. , 2013, Gene.
[20] V. Poggi,et al. Glutathione S-transferase homozygous deletions and relapse in childhood acute lymphoblastic leukemia: a novel study design in a large Italian AIEOP cohort. , 2012, Pharmacogenomics.
[21] Tanya M. Teslovich,et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.
[22] Frank B Hu,et al. Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges. , 2012, Annual review of nutrition.
[23] Takashi Aoi,et al. Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells , 2012, Proceedings of the National Academy of Sciences.
[24] J. Gustafsson,et al. Rapid Insulinotropic Action of Low Doses of Bisphenol-A on Mouse and Human Islets of Langerhans: Role of Estrogen Receptor β , 2012, PloS one.
[25] Rahul C. Deo,et al. Programming human pluripotent stem cells into white and brown adipocytes , 2012, Nature Cell Biology.
[26] D. Surmeier,et al. Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD , 2011, Nature.
[27] E. Stanley,et al. INSGFP/w human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells , 2011, Diabetologia.
[28] Constantin Polychronakos,et al. A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci , 2011, PLoS genetics.
[29] R. Scharfmann,et al. A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion. , 2011, The Journal of clinical investigation.
[30] Brian A. Neel,et al. The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic , 2011, Diabetes.
[31] M. Nielen,et al. Recombinant cell bioassays for the detection of (gluco)corticosteroids and endocrine-disrupting potencies of several environmental PCB contaminants , 2011, Analytical and bioanalytical chemistry.
[32] Ya-Wen Chen,et al. Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. , 2011, Toxicology letters.
[33] H. Pass,et al. Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation , 2010, Proceedings of the National Academy of Sciences.
[34] Cole Trapnell,et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.
[35] B. Ritz,et al. Well-Water Consumption and Parkinson’s Disease in Rural California , 2009, Environmental health perspectives.
[36] M. Knip,et al. Environmental factors in the pathogenesis of type 1 diabetes mellitus. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
[37] Helen Schuilenburg,et al. Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes , 2009, Nature Genetics.
[38] S. Schreiber,et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. , 2009, Nature chemical biology.
[39] M. Tomishima,et al. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling , 2009, Nature Biotechnology.
[40] Robert B Wallace,et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. , 2008, JAMA.
[41] C. Davie. A review of Parkinson's disease. , 2008, British medical bulletin.
[42] D. Maraganore,et al. A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease , 2007, PLoS genetics.
[43] Hansjürgen Bratzke,et al. Stages in the development of Parkinson’s disease-related pathology , 2004, Cell and Tissue Research.
[44] Uta Dirksen,et al. Glutathione S Transferase Theta 1 Gene (GSTT1) Null Genotype Is Associated with an Increased Risk for Acquired Aplastic Anemia in Children , 2004, Pediatric Research.
[45] D. Townsend,et al. The role of glutathione-S-transferase in anti-cancer drug resistance , 2003, Oncogene.
[46] P. Langer,et al. High Prevalence of Anti-Glutamic Acid Decarboxylase (Anti-GAD) Antibodies in Employees at a Polychlorinated Biphenyl Production Factory , 2002, Archives of environmental health.
[47] T. Misteli,et al. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.
[48] M. Longnecker,et al. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. , 2001, Diabetes care.
[49] Takeshi Noda,et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.
[50] G. Grodsky,et al. Insulinopenic Diabetes After Rodenticide (Vacor) Ingestion: A Unique Model of Acquired Diabetes in Man , 1980, Diabetes.
[51] Alexandru Almasan,et al. Histone H2AX phosphorylation: a marker for DNA damage. , 2012, Methods in molecular biology.
[52] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.