The role of hyperpolarization‐activated cationic current in spike‐time precision and intrinsic resonance in cortical neurons in vitro

Non‐technical summary We determined here the role of the hyperpolarization‐activated cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 pyramidal neurons the h‐current has three main actions. In addition to setting intrinsic resonance frequency at ∼4 Hz, the h‐current determines, through two main mechanisms, the temporal precision of action potentials evoked by excitatory postsynaptic potentials or following stimulation of inhibitory postsynaptic potentials (rebound spiking). We propose that h‐channels participate in the fine tuning of oscillatory activity in hippocampal and neocortical networks.

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