Network Analysis System for Traditional Chinese Medicine Clinical Data

Traditional Chinese medicine (TCM) is a clinical medical discipline with clinical data as one of the main knowledge sources. The clinical information (e.g. symptoms, diagnoses and herb prescriptions) that is captured, generated and used by TCM physicians has complicated inter or intra relationships between the different elements. Due to the co- occurrence and combinational properties, TCM clinical data could naturally be represented by networks. This paper introduces a complex network analysis system to model and analyze the TCM clinical data. The system could automatically generate the networks from the clinical database, query the generated network data from the database and has the social network analysis abilities (e.g. measurements and community identification). It integrated the TCM knowledge (e.g. herb properties) to visualize the clinical data (e.g. herb prescriptions, symptoms and diagnoses) by networks, and can help acquire the core medical structures or relationships from the large-scale clinical data. It shows that the system provides a helpful platform for TCM clinical data analysis and the network analyses could generate clinically meaningful knowledge.

[1]  A. Barabasi,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[2]  G Fisch,et al.  Traditional chinese medicine , 2015, Reactions Weekly.

[3]  A. Barabasi,et al.  The human disease network , 2007, Proceedings of the National Academy of Sciences.

[4]  A. Barabasi,et al.  Drug—target network , 2007, Nature Biotechnology.

[5]  A. Barabasi,et al.  Lethality and centrality in protein networks , 2001, Nature.

[6]  Mark E. J. Newman,et al.  Structure and Dynamics of Networks , 2009 .

[7]  A. Hopkins Network pharmacology: the next paradigm in drug discovery. , 2008, Nature chemical biology.

[8]  A. Barabasi,et al.  Network medicine--from obesity to the "diseasome". , 2007, The New England journal of medicine.

[9]  Baoyan Liu,et al.  Development of traditional Chinese medicine clinical data warehouse for medical knowledge discovery and decision support , 2010, Artif. Intell. Medicine.

[10]  M. DePamphilis,et al.  HUMAN DISEASE , 1957, The Ulster Medical Journal.

[11]  R. Albert,et al.  The large-scale organization of metabolic networks , 2000, Nature.

[12]  Jin-Ling Tang,et al.  Traditional Chinese medicine , 2008, The Lancet.