Protein kinase Mζ is necessary and sufficient for LTP maintenance

Long-term potentiation (LTP), a persistent synaptic enhancement thought to be a substrate for memory, can be divided into two phases: induction, triggering potentiation, and maintenance, sustaining it over time. Many postsynaptic events are implicated in induction, including N-methyl-D-aspartate receptor (NMDAR) activation, calcium increases and stimulation of several protein kinases; in contrast, the mechanism maintaining LTP is not yet characterized. Here we show the constitutively active form of an atypical protein kinase C (PKC) isozyme, protein kinase M zeta (PKMζ), is necessary and sufficient for LTP maintenance.

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