Extracellular electron transfer

Abstract. Results from several laboratories indicate that extracellular electron transfer may be a general mechanism whereby microoorganisms generate energy for cell growth and/or maintenance. Specifically, bacteria can use redox-active organic small molecules, generated outside or inside the cells, to shuttle electrons between reduced and oxidized compounds. Electron shuttling has now been reported for several different bacterial species, and exchanges of shuttling compounds may even syntrophically link diverse organisms in nature. Biofilm systems in both geological and clinical settings are likely to be important environments for metabolisms that employ extracellular electron transfer. Both structural and functional analyses suggest that electron shuttles and some virulence factors may be related to one another.

[1]  Kelly P. Nevin,et al.  Enrichment of Geobacter Species in Response to Stimulation of Fe(III) Reduction in Sandy Aquifer Sediments , 2000, Microbial Ecology.

[2]  P. Mitchell.  Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism , 1961, Nature.

[3]  A. Butler,et al.  Structure of putrebactin, a new dihydroxamate siderophore produced by Shewanella putrefaciens , 1997, JBIC Journal of Biological Inorganic Chemistry.

[4]  Dianne K. Newman,et al.  A role for excreted quinones in extracellular electron transfer , 2000, Nature.

[5]  P. Kovacic,et al.  Mode of action of anti-infective agents: focus on oxidative stress and electron transfer. , 2000, Current pharmaceutical design.

[6]  D. Rees,et al.  Structure and stability of membrane proteins. , 1995, Advances in protein chemistry.

[7]  K. Nealson,et al.  Breathing Manganese and Iron: Solid-State Respiration , 1997 .

[8]  T. Schmidt,et al.  Phylogenetic analysis of dissimilatory Fe(III)-reducing bacteria , 1996, Journal of bacteriology.

[9]  M. Hoffmann,et al.  Reductive dissolution of fe(III) oxides by Pseudomonas sp. 200 , 1988, Biotechnology and bioengineering.

[10]  K. Straub,et al.  Iron metabolism in anoxic environments at near neutral pH. , 2001, FEMS microbiology ecology.

[11]  D. Lovley,et al.  Novel Mode of Microbial Energy Metabolism: Organic Carbon Oxidation Coupled to Dissimilatory Reduction of Iron or Manganese , 1988, Applied and environmental microbiology.

[12]  D. Lovley,et al.  Humic Substances as a Mediator for Microbially Catalyzed Metal Reduction , 1998 .

[13]  J. Winkler,et al.  Electron Transfer In Proteins , 1997, QELS '97., Summaries of Papers Presented at the Quantum Electronics and Laser Science Conference.

[14]  Clare E. Reimers,et al.  In Situ Deployment of Voltammetric, Potentiometric, and Amperometric Microelectrodes from a ROV To Determine Dissolved O2, Mn, Fe, S(-2), and pH in Porewaters , 1999 .

[15]  Janet G. Hering,et al.  Principles and Applications of Aquatic Chemistry , 1993 .

[16]  Kelly P. Nevin,et al.  Potential for Nonenzymeatic Reduction of Fe(III) vio Electron Shuttling in Subsurface Sediments , 2000 .

[17]  D. Westlake,et al.  Effects of medium composition on cell pigmentation, cytochrome content, and ferric iron reduction in a Pseudomonas sp. isolated from crude oil. , 1982, Canadian journal of microbiology.

[18]  K. Kano,et al.  Role of 2-amino-3-carboxy-1,4-naphthoquinone, a strong growth stimulator for bifidobacteria, as an electron transfer mediator for NAD(P)(+) regeneration in Bifidobacterium longum. , 1999, Biochimica et biophysica acta.

[19]  K. König,et al.  Multiphoton microscopy in life sciences , 2000, Journal of microscopy.

[20]  I. Swift,et al.  New signal molecules on the quorum-sensing block. , 2000, Trends in microbiology.

[21]  D. Lovley,et al.  Rapid Anaerobic Benzene Oxidation with a Variety of Chelated Fe(III) Forms , 1996, Applied and environmental microbiology.

[22]  K. Raymond,et al.  A Preorganized Siderophore: Thermodynamic and Structural Characterization of Alcaligin and Bisucaberin, Microbial Macrocyclic Dihydroxamate Chelating Agents(1). , 1998, Inorganic chemistry.

[23]  J. Handelsman,et al.  The Earth's bounty: assessing and accessing soil microbial diversity. , 1999, Trends in biotechnology.

[24]  C. Myers,et al.  Role of menaquinone in the reduction of fumarate, nitrate, iron(III) and manganese(IV) by Shewanella putrefaciens MR‐1 , 1993 .

[25]  Derek R. Lovley,et al.  Lack of Production of Electron-Shuttling Compounds or Solubilization of Fe(III) during Reduction of Insoluble Fe(III) Oxide by Geobacter metallireducens , 2000, Applied and Environmental Microbiology.

[26]  C. D. Cox.  Role of pyocyanin in the acquisition of iron from transferrin , 1986, Infection and immunity.

[27]  Kelly P. Nevin,et al.  Mechanisms for Fe(III) Oxide Reduction in Sedimentary Environments , 2002 .

[28]  C. Holliger,et al.  Localization and Solubilization of the Iron(III) Reductase of Geobacter sulfurreducens , 1998, Applied and Environmental Microbiology.

[29]  P. Dobbin,et al.  Purification and Magneto-optical Spectroscopic Characterization of Cytoplasmic Membrane and Outer Membrane Multiheme c-Type Cytochromes from Shewanella frigidimarina NCIMB400* , 2000, The Journal of Biological Chemistry.

[30]  A. Blackwood,et al.  Microbial Production of Phenazines , 1970 .

[31]  R. Crawford,et al.  Identification of an Extracellular Catalyst of Carbon Tetrachloride Dehalogenation from Pseudomonas stutzeri Strain KC as Pyridine-2,6-bis(thiocarboxylate) , 1999 .

[32]  K. Nealson,et al.  Iron and manganese in anaerobic respiration: environmental significance, physiology, and regulation. , 1994, Annual review of microbiology.

[33]  J. Neilands,et al.  Siderophores: Structure and Function of Microbial Iron Transport Compounds (*) , 1995, The Journal of Biological Chemistry.

[34]  K. Nealson,et al.  Respiration-linked proton translocation coupled to anaerobic reduction of manganese(IV) and iron(III) in Shewanella putrefaciens MR-1 , 1990, Journal of bacteriology.

[35]  D. Lovley,et al.  Humic substances as electron acceptors for microbial respiration , 1996, Nature.

[36]  Matthew R. Parsek,et al.  Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms , 2000, Nature.

[37]  D. Richardson,et al.  Bacterial respiration: a flexible process for a changing environment. , 2000, Microbiology.

[38]  S. Ragsdale,et al.  Characterization of the Intramolecular Electron Transfer Pathway from 2-Hydroxyphenazine to the Heterodisulfide Reductase fromMethanosarcina thermophila * , 2001, The Journal of Biological Chemistry.

[39]  M. McFall-Ngai.  Consequences of evolving with bacterial symbionts : Insights from the squid-vibrio associations , 1999 .

[40]  Ralf Cord-Ruwisch,et al.  A Periplasmic and Extracellular c-Type Cytochrome ofGeobacter sulfurreducens Acts as a Ferric Iron Reductase and as an Electron Carrier to Other Acceptors or to Partner Bacteria , 1998, Journal of bacteriology.

[41]  R. Caspi,et al.  Bacterially mediated mineral formation; insights into manganese(II) oxidation from molecular genetic and biochemical studies , 1997 .

[42]  B. Bassler.  How bacteria talk to each other: regulation of gene expression by quorum sensing. , 1999, Current opinion in microbiology.

[43]  Colin Hughes,et al.  Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export , 2000, Nature.

[44]  U. Deppenmeier,et al.  Isolation and Characterization of Methanophenazine and Function of Phenazines in Membrane-Bound Electron Transport ofMethanosarcina mazei Gö1 , 1998, Journal of bacteriology.

[45]  A. Beliaev,et al.  MtrC, an outer membrane decahaem c cytochrome required for metal reduction in Shewanella putrefaciens MR‐1 , 2001, Molecular microbiology.

[46]  C. Myers,et al.  Localization of cytochromes to the outer membrane of anaerobically grown Shewanella putrefaciens MR-1 , 1992, Journal of bacteriology.

[47]  D. Lovley,et al.  Quinone Moieties Act as Electron Acceptors in the Reduction of Humic Substances by Humics-Reducing Microorganisms , 1998 .

[48]  B. Schink,et al.  Humic Acid Reduction by Propionibacterium freudenreichii and Other Fermenting Bacteria , 1998, Applied and Environmental Microbiology.

[49]  K. M. Lee,et al.  Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[50]  A. Beliaev,et al.  Shewanella putrefaciens mtrB Encodes an Outer Membrane Protein Required for Fe(III) and Mn(IV) Reduction , 1998 .

[51]  J. Costerton,et al.  The involvement of cell-to-cell signals in the development of a bacterial biofilm. , 1998, Science.

[52]  L. Michaelis,et al.  POTENTIOMETRIC STUDY OF PYOCYANINE , 1931 .

[53]  A. Beliaev,et al.  Shewanella putrefaciens mtrB Encodes an Outer Membrane Protein Required for Fe(III) and Mn(IV) Reduction , 1998, Journal of bacteriology.

[54]  D. Lovley,et al.  Reduction of humic substances and Fe(III) by hyperthermophilic microorganisms , 2000 .