To achieve the strict requirements for data ac- quisition and communication of modern medical monitoring, a design approach for physiological parameter acquisition and communication module based on ZigBee technology is pre- sented. This approach used the chip of CC2430, which was integrated of AD converter, 8-bit strengthened MCU and wireless RF unit. It realized the functions of data acquisition, wave filtering and wireless transmission. It can also communi- cate with peripheral devices via serial ports and then instruct medical equipments to realize system control. It changed the traditional medical care which cable connections are abso- lutely necessary. The system presented in this paper can enable patients to be tested in a more comfortable state, improving the quality of medical care. The module has a simple structure, low power consumption. It is suitable for developing family- oriented portable medical equipments.