Pavlov's moth: olfactory learning and spike timing–dependent plasticity

Spike-timing dependent plasticity is a favored synaptic mechanism for learning. However, a surprising new study by Ito and colleagues in the insect mushroom body suggests that it cannot account for a paradigmatic form of learning.

[1]  Bruno A Olshausen,et al.  Sparse coding of sensory inputs , 2004, Current Opinion in Neurobiology.

[2]  L. Abbott,et al.  Extending the effects of spike-timing-dependent plasticity to behavioral timescales. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[3]  G. Laurent,et al.  Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts , 2007, Nature.

[4]  S. Waddell,et al.  Sequential Use of Mushroom Body Neuron Subsets during Drosophila Odor Memory Processing , 2007, Neuron.

[5]  Y. Dan,et al.  Spike timing-dependent plasticity: from synapse to perception. , 2006, Physiological reviews.

[6]  M. Bitterman,et al.  Classical conditioning of proboscis extension in honeybees (Apis mellifera). , 1983, Journal of comparative psychology.

[7]  L. Abbott,et al.  Synaptic plasticity: taming the beast , 2000, Nature Neuroscience.

[8]  Johannes J. Letzkus,et al.  DOES SPIKE TIMING‐DEPENDENT SYNAPTIC PLASTICITY UNDERLIE MEMORY FORMATION? , 2007, Clinical and experimental pharmacology & physiology.

[9]  Glenn C. Turner,et al.  Oscillations and Sparsening of Odor Representations in the Mushroom Body , 2002, Science.

[10]  M. Martina,et al.  Subthreshold contribution of N-methyl-d-aspartate receptors to long-term potentiation induced by low-frequency pairing in rat hippocampal CA1 pyramidal cells , 2004, Neuroscience.

[11]  W. Levy,et al.  Temporal contiguity requirements for long-term associative potentiation/depression in the hippocampus , 1983, Neuroscience.

[12]  B. Raman,et al.  Sparse odor representation and olfactory learning , 2008, Nature Neuroscience.