A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas.

[1]  Shannon M. White,et al.  YAP/TAZ Inhibition Induces Metabolic and Signaling Rewiring Resulting in Targetable Vulnerabilities in NF2-Deficient Tumor Cells. , 2019, Developmental cell.

[2]  Shannon M. White,et al.  The complex entanglement of Hippo-Yap/Taz signaling in tumor immunity , 2019, Oncogene.

[3]  R. Weinberg,et al.  Epithelial-to-mesenchymal transition in cancer: complexity and opportunities , 2018, Frontiers of Medicine.

[4]  G. Eibl,et al.  Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival , 2018, Signal Transduction and Targeted Therapy.

[5]  R. Premont,et al.  Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells. , 2018, Gastroenterology.

[6]  J. Park,et al.  The Role of Hippo Pathway in Cancer Stem Cell Biology , 2018, Molecules and cells.

[7]  Ho-Joon Lee,et al.  Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma , 2018, JCI insight.

[8]  Mathias J Friedrich,et al.  Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes , 2018, Nature.

[9]  Karl-Heinz Krause,et al.  Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma. , 2017, Cancer cell.

[10]  E. Shiuan,et al.  The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ , 2017, Science Signaling.

[11]  G. Evan,et al.  Myc Cooperates with Ras by Programming Inflammation and Immune Suppression , 2017, Cell.

[12]  F. Biagioni,et al.  Transcriptional integration of mitogenic and mechanical signals by Myc and YAP , 2017, Genes & development.

[13]  L. Wood,et al.  A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. , 2017, Cancer cell.

[14]  M. Tomita,et al.  Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC , 2017, Proceedings of the National Academy of Sciences.

[15]  Xuexiang Han,et al.  A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer. , 2017, Cancer letters.

[16]  Songchuan Guo,et al.  Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations , 2017, World journal of clinical oncology.

[17]  O. Sansom,et al.  Modulating the therapeutic response of tumours to dietary serine and glycine starvation , 2017, Nature.

[18]  A. Rizzino,et al.  The dark side of SOX2: cancer - a comprehensive overview , 2017, Oncotarget.

[19]  R. Klose,et al.  The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells , 2017, eLife.

[20]  J. Ernst,et al.  Cooperative Binding of Transcription Factors Orchestrates Reprogramming , 2017, Cell.

[21]  C. Lyssiotis,et al.  Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. , 2017, Cancer cell.

[22]  Shannon M. White,et al.  Rac1-Mediated DNA Damage and Inflammation Promote Nf2 Tumorigenesis but Also Limit Cell-Cycle Progression. , 2016, Developmental cell.

[23]  S. Manley,et al.  A role for mitotic bookmarking of SOX2 in pluripotency and differentiation , 2016, Genes & development.

[24]  M. Peinado,et al.  DNA methylation dynamics in cellular commitment and differentiation. , 2016, Briefings in functional genomics.

[25]  B. Spencer‐Dene,et al.  YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling , 2016, Gastroenterology.

[26]  John M. Asara,et al.  Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth , 2016, Nature Cell Biology.

[27]  Shannon M. White,et al.  Yes-Associated Protein Mediates Immune Reprogramming in Pancreatic Ductal Adenocarcinoma , 2016, Oncogene.

[28]  Stefano Piccolo,et al.  YAP/TAZ at the Roots of Cancer. , 2016, Cancer cell.

[29]  R. Gibbs,et al.  Genomic analyses identify molecular subtypes of pancreatic cancer , 2016, Nature.

[30]  Howard Y. Chang,et al.  The histone chaperone CAF-1 safeguards somatic cell identity , 2015, Nature.

[31]  C. Dang,et al.  MYC, Metabolism, and Cancer. , 2015, Cancer discovery.

[32]  Antonio Rosato,et al.  Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth , 2015, Nature Cell Biology.

[33]  M. Karin,et al.  A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis , 2015, Genes & development.

[34]  W. Bamlet,et al.  Antithetical NFATc1–Sox2 and p53–miR200 signaling networks govern pancreatic cancer cell plasticity , 2015, The EMBO journal.

[35]  Randy L. Johnson,et al.  AMPK modulates Hippo pathway activity to regulate energy homeostasis , 2015, Nature Cell Biology.

[36]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[37]  D. Corey,et al.  C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells , 2014, Stem cell reports.

[38]  Yanli Wang,et al.  Topologically associating domains are stable units of replication-timing regulation , 2014, Nature.

[39]  Christian Veltkamp,et al.  A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer , 2014, Nature Medicine.

[40]  Shan Jiang,et al.  Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer , 2014, Cell.

[41]  Patrick Cahan,et al.  Hippo Pathway Activity Influences Liver Cell Fate , 2014, Cell.

[42]  Joseph Rosenbluh,et al.  KRAS and YAP1 Converge to Regulate EMT and Tumor Survival , 2014, Cell.

[43]  A. Wellstein,et al.  Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma , 2014, Science Signaling.

[44]  Timothy E. Reddy,et al.  Distinct properties of cell-type-specific and shared transcription factor binding sites. , 2013, Molecular cell.

[45]  W. Bamlet,et al.  SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells , 2013, Oncogenesis.

[46]  P. Robson,et al.  Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm , 2013, The EMBO journal.

[47]  John M. Asara,et al.  Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway , 2013, Nature.

[48]  G. Evan,et al.  Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. , 2013, Genes & development.

[49]  A. Üren,et al.  Quantifying the CDK inhibitor VMY-1-103’s activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI , 2012, Cell cycle.

[50]  Data production leads,et al.  An integrated encyclopedia of DNA elements in the human genome , 2012 .

[51]  ENCODEConsortium,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[52]  Gerald C. Chu,et al.  Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.

[53]  Bond-Smith Giles,et al.  Only women with symptoms need to have their breast implants removed, says government , 2012 .

[54]  C. Galbán,et al.  Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. , 2012, The Journal of clinical investigation.

[55]  M. C. Jørgensen,et al.  Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism , 2012, Development.

[56]  L. Johnston,et al.  Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. , 2010, Developmental cell.

[57]  M. Giovannini,et al.  The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. , 2010, Developmental cell.

[58]  Gerald C. Chu,et al.  Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. , 2009, Cancer cell.

[59]  A. Regev,et al.  SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas , 2009, Nature Genetics.

[60]  G. Feldmann,et al.  Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice , 2008, Proceedings of the National Academy of Sciences.

[61]  G. Evan,et al.  Modelling Myc inhibition as a cancer therapy , 2008, Nature.

[62]  M. Barbacid,et al.  Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. , 2007, Cancer cell.

[63]  Jianmin Zhang,et al.  Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon , 2006, Proceedings of the National Academy of Sciences.

[64]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[65]  W. Hahn,et al.  Transformation of Human and Murine Fibroblasts without Viral Oncoproteins , 2005, Molecular and Cellular Biology.

[66]  R. Hruban,et al.  Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.

[67]  R. DePinho,et al.  Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. , 2003, Genes & development.

[68]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.

[69]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[70]  L. Papagiannoulis,et al.  Multifactorial analysis of the aetiology of craniomandibular dysfunction in children. , 2002, International journal of paediatric dentistry.

[71]  P. Froguel,et al.  Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. , 1998, The Journal of clinical investigation.

[72]  E. Gottlieb,et al.  Analysis of Cell Metabolism Using LC-MS and Isotope Tracers. , 2015, Methods in enzymology.

[73]  N. Bardeesy,et al.  Pancreatic adenocarcinoma. , 2014, The New England journal of medicine.

[74]  B. Croy,et al.  Evaluation of the pregnancy immunotrophism hypothesis by assessment of the reproductive performance of young adult mice of genotype scid/scid.bg/bg. , 1990, Journal of reproduction and fertility.