Mast cells disrupt the function of the esophageal epithelial barrier.

[1]  A. Bredenoord,et al.  In vivo and ex vivo inflammatory responses of the esophageal mucosa to food challenge in adults with eosinophilic esophagitis , 2023, Allergy.

[2]  T. Tomita,et al.  Esophageal Mucosal Permeability as a Surrogate Measure of Cure in Eosinophilic Esophagitis , 2022, Journal of clinical medicine.

[3]  P. Dexheimer,et al.  Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation , 2022, JCI insight.

[4]  N. Barrett,et al.  Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation and activation that persists in remission. , 2022, The Journal of allergy and clinical immunology.

[5]  E. Dellon,et al.  Mast cell‐pain connection in eosinophilic esophagitis , 2022, Allergy.

[6]  Z. Modrušan,et al.  Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma , 2022, Science Translational Medicine.

[7]  D. Katzka,et al.  Eosinophilic Esophagitis. , 2021, The New England journal of medicine.

[8]  A. Bredenoord,et al.  Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function , 2021, Allergy.

[9]  C. Akdis Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? , 2021, Nature Reviews Immunology.

[10]  J. L. Dunn,et al.  Bidirectional Crosstalk Between Eosinophils and Esophageal Epithelial Cells Regulates Inflammatory and Remodeling Processes , 2021, Mucosal Immunology.

[11]  J. Raes,et al.  Local immune response to food antigens drives meal-induced abdominal pain , 2021, Nature.

[12]  B. Becher,et al.  GM-CSF instigates a dendritic cell - T cell inflammatory circuit that drives chronic asthma development. , 2021, The Journal of allergy and clinical immunology.

[13]  A. Zekiy,et al.  Oncostatin M: A mysterious cytokine in cancers. , 2020, International immunopharmacology.

[14]  John A. Besse,et al.  Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis , 2020, Science Translational Medicine.

[15]  E. Dellon,et al.  Mast Cell Infiltration Is Associated With Persistent Symptoms and Endoscopic Abnormalities Despite Resolution of Eosinophilia in Pediatric Eosinophilic Esophagitis. , 2020, The American journal of gastroenterology.

[16]  P. Hellings,et al.  Nasal epithelial barrier dysfunction increases sensitization and mast cell degranulation in the absence of allergic inflammation , 2019, Allergy.

[17]  S. Nobs,et al.  GM‐CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation , 2019, The Journal of allergy and clinical immunology.

[18]  Xiaoying Zhou,et al.  Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells , 2018, Allergy.

[19]  J. Garssen,et al.  Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models , 2018, Oncoimmunology.

[20]  A. Stalder,et al.  Eosinophilic oesophagitis: relevance of mast cell infiltration , 2018, Histopathology.

[21]  Lisa J. Martin,et al.  The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses , 2018, Science Translational Medicine.

[22]  J. Lieberman,et al.  A randomized, double-blinded, placebo-controlled study of the use of viscous oral cromolyn sodium for the treatment of eosinophilic esophagitis. , 2018, Annals of Allergy, Asthma & Immunology.

[23]  P. Hellings,et al.  Histamine and T helper cytokine–driven epithelial barrier dysfunction in allergic rhinitis , 2017, The Journal of allergy and clinical immunology.

[24]  S. Valitutti,et al.  IL‐33 fine tunes mast cell degranulation and chemokine production at the single‐cell level , 2017, The Journal of allergy and clinical immunology.

[25]  R. Schleimer,et al.  The barrier hypothesis and Oncostatin M: Restoration of epithelial barrier function as a novel therapeutic strategy for the treatment of type 2 inflammatory disease , 2017, Tissue barriers.

[26]  D. Katzka,et al.  The Esophageal Epithelial Barrier in Health and Disease , 2017, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[27]  A. Peters,et al.  Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease , 2017, The Journal of allergy and clinical immunology.

[28]  W. D. de Jonge,et al.  Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet , 2017, The American Journal of Gastroenterology.

[29]  Adeeb Rahman,et al.  Clustergrammer, a web-based heatmap visualization and analysis tool for high-dimensional biological data , 2017, Scientific Data.

[30]  Xinzhong Dong,et al.  Different activation signals induce distinct mast cell degranulation strategies. , 2016, Journal of Clinical Investigation.

[31]  F. Thien,et al.  Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities , 2016, Alimentary pharmacology & therapeutics.

[32]  J. Garssen,et al.  Non-IgE mediated mast cell activation. , 2016, European journal of pharmacology.

[33]  A. Muraro,et al.  Eosinophilic esophagitis is characterized by a non‐IgE‐mediated food hypersensitivity , 2016, Allergy.

[34]  E. Stucke,et al.  Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. , 2016, JCI insight.

[35]  A. Peters,et al.  Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease. , 2015, The Journal of allergy and clinical immunology.

[36]  M. Camilleri,et al.  Endoscopic Mucosal Impedance Measurements Correlate With Eosinophilia and Dilation of Intercellular Spaces in Patients With Eosinophilic Esophagitis. , 2015, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[37]  M. Rothenberg,et al.  In Vitro Model for Studying Esophageal Epithelial Differentiation and Allergic Inflammatory Responses Identifies Keratin Involvement in Eosinophilic Esophagitis , 2015, PloS one.

[38]  O. Goker-Alpan,et al.  A Pilot Study of Omalizumab in Eosinophilic Esophagitis , 2015, PloS one.

[39]  H. Nakagawa,et al.  Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis , 2015, PloS one.

[40]  F. Thien,et al.  IgG and EoE: too soon for a paradigm shift away from IgE. , 2015, Gastroenterology.

[41]  Scott H Sicherer,et al.  Food allergy: a practice parameter update-2014. , 2014, The Journal of allergy and clinical immunology.

[42]  F. Clayton,et al.  Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE. , 2014, Gastroenterology.

[43]  B. Aronow,et al.  Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing , 2014, Genes and Immunity.

[44]  R. Farré,et al.  IL-4 induces columnar-like differentiation of esophageal squamous epithelium through JAK/PI3K pathway: possible role in pathogenesis of Barrett's esophagus. , 2014, American journal of physiology. Gastrointestinal and liver physiology.

[45]  W. Zwart,et al.  Supplementary Materials and Methods , 2013 .

[46]  G. Boeckxstaens,et al.  Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism , 2013, Gut.

[47]  Q. Sattentau,et al.  Thymic stromal lymphopoietin–elicited basophil responses promote eosinophilic esophagitis , 2013, Nature Medicine.

[48]  D. Broide,et al.  Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis. , 2013, The Journal of allergy and clinical immunology.

[49]  C. Justinich,et al.  Atopic and non‐atopic eosinophilic oesophagitis are distinguished by immunoglobulin E‐bearing intraepithelial mast cells , 2012, Histopathology.

[50]  M. Herlyn,et al.  Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture , 2012, Nature Protocols.

[51]  M. Jordana,et al.  A Mouse Model of Airway Disease: Oncostatin M-Induced Pulmonary Eosinophilia, Goblet Cell Hyperplasia, and Airway Hyperresponsiveness Are STAT6 Dependent, and Interstitial Pulmonary Fibrosis Is STAT6 Independent , 2011, The Journal of Immunology.

[52]  D. Broide,et al.  Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction. , 2010, The Journal of allergy and clinical immunology.

[53]  K. Stringer,et al.  Involvement of mast cells in eosinophilic esophagitis. , 2010, The Journal of allergy and clinical immunology.

[54]  Lisa J. Martin,et al.  Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in Eosinophilic Esophagitis , 2010, The Journal of Immunology.

[55]  Jodie L Simpson,et al.  ONCOSTATIN M (OSM) IS INCREASED IN ASTHMA WITH INCOMPLETELY REVERSIBLE AIRFLOW OBSTRUCTION , 2009, Experimental lung research.

[56]  M. Vicario,et al.  Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis , 2009, Gut.

[57]  C. Rondón,et al.  Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response , 2008, Allergy.

[58]  M. Herlyn,et al.  The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. , 2007, Genes & development.

[59]  A. Klein-Szanto,et al.  AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture , 2007, Oncogene.

[60]  S. Chevalier,et al.  Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation1 , 2007, The Journal of Immunology.

[61]  M. Rothenberg,et al.  Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice , 2007 .

[62]  M. Blumenberg,et al.  A characteristic subset of psoriasis-associated genes is induced by oncostatin-M in reconstituted epidermis. , 2006, The Journal of investigative dermatology.

[63]  S. Chae,et al.  Upregulation of Oncostatin M in Allergic Rhinitis , 2005, The Laryngoscope.

[64]  K. Chida,et al.  Oncostatin M production by human dendritic cells in response to bacterial products. , 2002, Cytokine.

[65]  D. Friend,et al.  Dual Oncostatin M (OSM) Receptors , 1996, The Journal of Biological Chemistry.

[66]  H. Marquardt,et al.  Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells. , 1987, Journal of immunology.

[67]  A. Straumann,et al.  Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. , 2001, The Journal of allergy and clinical immunology.