Tissue elasticity properties as biomarkers for prostate cancer.

In this paper we evaluate tissue elasticity as a longstanding but qualitative biomarker for prostate cancer and sonoelastography as an emerging imaging tool for providing qualitative and quantitative measurements of prostate tissue stiffness. A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic model was used to characterize mechanical stress relaxation data measured from human prostate tissue samples. Mechanical testing results revealed that the viscosity parameter for cancerous prostate tissue is greater than that derived from normal tissue by a factor of approximately 2.4. It was also determined that a significant difference exists between normal and cancerous prostate tissue stiffness (p < 0.01) yielding an average elastic contrast that increases from 2.1 at 0.1 Hz to 2.5 at 150 Hz. Qualitative sonoelastographic results show promise for cancer detection in prostate and may prove to be an effective adjunct imaging technique for biopsy guidance. Elasticity images obtained with quantitative sonoelastography agree with mechanical testing and histological results. Overall, results indicate tissue elasticity is a promising biomarker for prostate cancer.

[1]  K. Parker,et al.  On estimating the amplitude of harmonic vibration from the Doppler spectrum of reflected signals , 1990 .

[2]  K. Parker,et al.  "Sonoelasticity" images derived from ultrasound signals in mechanically vibrated tissues. , 1990, Ultrasound in medicine & biology.

[3]  D. Rubens,et al.  Sonoelasticity imaging of prostate cancer: in vitro results. , 1995, Radiology.

[4]  K J Parker,et al.  Imaging of the elastic properties of tissue--a review. , 1996, Ultrasound in medicine & biology.

[5]  B. Garra,et al.  Elastography of breast lesions: initial clinical results. , 1997, Radiology.

[6]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[7]  K J Parker,et al.  Vibration sonoelastography and the detectability of lesions. , 1998, Ultrasound in medicine & biology.

[8]  R. Portenoy,et al.  Management of cancer pain , 1999, The Lancet.

[9]  T. Krouskop,et al.  Elastography: Ultrasonic estimation and imaging of the elastic properties of tissues , 1999, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[10]  H. Ermert,et al.  A new system for the acquisition of ultrasonic multicompression strain images of the human prostate in vivo , 1999, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[11]  T. Szabo,et al.  A model for longitudinal and shear wave propagation in viscoelastic media , 2000, The Journal of the Acoustical Society of America.

[12]  L. S. Taylor,et al.  Three-dimensional sonoelastography: principles and practices. , 2000, Physics in medicine and biology.

[13]  A Fenster,et al.  Prostate boundary segmentation from 2D ultrasound images. , 2000, Medical physics.

[14]  A J Bailey,et al.  Changes in collagen metabolism in prostate cancer: a host response that may alter progression. , 2001, The Journal of urology.

[15]  L. Heuser,et al.  Freehand ultrasound elastography of breast lesions: clinical results. , 2001, Ultrasound in medicine & biology.

[16]  G. Ayala,et al.  Reactive stroma in prostate cancer progression. , 2001, The Journal of urology.

[17]  A. Pesavento,et al.  Real time strain imaging and in-vivo applications in prostate cancer , 2001, 2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263).

[18]  G. Ayala,et al.  Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[19]  Lawrence Steven Taylor.  Three-dimensional sonoelastography: Principles and practices with application to tumor visualization and volume estimation , 2002 .

[20]  J. Greenleaf,et al.  Selected methods for imaging elastic properties of biological tissues. , 2003, Annual review of biomedical engineering.

[21]  J Bercoff,et al.  In vivo breast tumor detection using transient elastography. , 2003, Ultrasound in medicine & biology.

[22]  Yulan Jin,et al.  Characteristics of normal stromal components and their correlation with cancer occurrence in human prostate. , 2003, Oncology reports.

[23]  T. Matsumura,et al.  High-speed Freehand Tissue Elasticity Imaging for Breast Diagnosis , 2003 .

[24]  Jonathan Ophir,et al.  Visualisation of HIFU lesions using elastography of the human prostate in vivo: preliminary results. , 2003, Ultrasound in medicine & biology.

[25]  C. S. Spalding,et al.  In vivo real-time freehand palpation imaging. , 2003, Ultrasound in medicine & biology.

[26]  Tomy Varghese,et al.  Viscoelastic characterization of in vitro canine tissue. , 2004, Physics in medicine and biology.

[27]  Zhe Wu,et al.  Sonoelastographic imaging of interference patterns for estimation of the shear velocity of homogeneous biomaterials , 2004, Physics in medicine and biology.

[28]  G. Roodman.  Mechanisms of bone metastasis. , 2004, Discovery medicine.

[29]  Helmut Ermert,et al.  Initial experiences with real-time elastography guided biopsies of the prostate. , 2005, The Journal of urology.

[30]  L. S. Taylor,et al.  Prostate cancer: three-dimensional sonoelastography for in vitro detection. , 2005, Radiology.

[31]  R. Reuben,et al.  Measurement of tissue mechanical characteristics to distinguish between benign and malignant prostatic disease. , 2005, Urology.

[32]  T. Matsumura,et al.  Breast disease: clinical application of US elastography for diagnosis. , 2006, Radiology.

[33]  Duane D. Meixner,et al.  Breast lesions: evaluation with US strain imaging--clinical experience of multiple observers. , 2006, Radiology.

[34]  O. Lindahl,et al.  Resonance sensor measurements of stiffness variations in prostate tissue in vitro—a weighted tissue proportion model , 2006, Physiological measurement.

[35]  Kenneth Hoyt,et al.  Sonoelastographic imaging of interference patterns for estimation of shear velocity distribution in biomaterials. , 2006, The Journal of the Acoustical Society of America.

[36]  Kenneth Hoyt,et al.  Real-time shear velocity imaging using sonoelastographic techniques. , 2007, Ultrasound in medicine & biology.

[37]  G. Bartsch,et al.  Value of contrast-enhanced ultrasound and elastography in imaging of prostate cancer , 2007, Current opinion in urology.

[38]  Kevin J. Parker,et al.  Lesion contrast and detection using sonoelastographic shear velocity imaging: preliminary results , 2007, SPIE Medical Imaging.