Reconfigurable fault-tolerant multielectrode array for dependable monitoring of the human brain

We introduce a fault-tolerant strategy to improve the dependability of a multi-electrode array (MEA), an issue of considerable concern. We propose an interstitial redundancy approach with local reconfiguration. Here spare modules are placed at interstitial sites and can replace neighboring primary modules when they develop faults. We evaluate the performance of such a system under different faults to characterize MEA dependability as a function of redundancy. The results demonstrate that a considerable improvement in MEA dependability can be achieved with a well designed increase in redundancy.

[1]  Steve S. Chung,et al.  Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy , 2010, Epilepsia.

[2]  D. Wilkins Reassessment: vagus nerve stimulation for epilepsy. , 2000, Neurology.

[3]  J. Csicsvari,et al.  Massively parallel recording of unit and local field potentials with silicon-based electrodes. , 2003, Journal of neurophysiology.

[4]  Tayfun Akin,et al.  A wireless implantable multichannel digital neural recording system for a micromachined sieve electrode , 1998, IEEE J. Solid State Circuits.

[5]  Kenneth Steiglitz,et al.  Combinatorial Optimization: Algorithms and Complexity , 1981 .

[6]  R. Oostenveld,et al.  A MEMS-based flexible multichannel ECoG-electrode array , 2009, Journal of neural engineering.

[7]  Peter Wolf,et al.  The Epidemiology of the Epilepsies: Future Directions , 1997 .

[8]  Shimon Even,et al.  Graph Algorithms , 1979 .

[9]  Monya Baker,et al.  From promising to practical: tools to study networks of neurons , 2010, Nature Methods.

[10]  J. Engel Surgical treatment for epilepsy: too little, too late? , 2008, JAMA.

[11]  Israel Koren,et al.  Fault-Tolerant Systems , 2007 .

[12]  D.R. Kipke,et al.  Implantable neural probe systems for cortical neuroprostheses , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[13]  P. Cochat,et al.  Et al , 2008, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[14]  Hitten P. Zaveri,et al.  Emerging Technologies for Brain-Implantable Devices , 2011 .

[15]  P. Kwan,et al.  Early identification of refractory epilepsy. , 2000, The New England journal of medicine.

[16]  Miguel A. L. Nicolelis,et al.  A multichannel CMOS analog front end IC for neural recordings , 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

[17]  G. Cascino,et al.  Surgical treatment for epilepsy , 2004, Epilepsy Research.

[18]  ILAE Commission Report. The epidemiology of the epilepsies: future directions. International League Against Epilepsy. , 1997, Epilepsia.