Anxiety after stroke: A systematic review and meta-analysis.

OBJECTIVE To update the evidence surrounding the presence of anxiety after stroke. DATA SOURCES A search was conducted in EMBASE, MEDLINE, PsycINFO, Cochrane Library, AMED and CINAHL in May 2015 and repeated in April 2017. STUDY SELECTION Clinical diagnosis of stroke and assessed for anxiety symptoms on a rating scale in the first year after stroke. DATA EXTRACTION One reviewer screened and identified studies against the inclusion criteria. A second reviewer conducted a random check of approximately 10% of titles and abstracts. Two authors independently performed the final full-text review. DATA SYNTHESIS Overall pooled prevalence of anxiety disorders was 29.3% ((95% confidence interval 24.8-33.8%), (I2 = 97%, p < 0.00001)) during the first year. Frequency 0-2 weeks post-stroke was 36.7%, 2 weeks to 3 months 24.1%, and 3-12 months 23.8%. There was a statistically high heterogeneity in this estimate (I2 = 97%, p < 0.00001). CONCLUSION Anxiety is common during the first year post-stroke. Since anxiety significantly influences quality of life and is a predictor for depression, it may be worth considering further routine screening post-stroke.

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