Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients.

[1]  M. Böhm,et al.  Heart rate reduction by If-inhibition improves vascular stiffness and left ventricular systolic and diastolic function in a mouse model of heart failure with preserved ejection fraction. , 2013, European heart journal.

[2]  R. Nishimura,et al.  Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy. , 2012, Journal of the American College of Cardiology.

[3]  Dario DiFrancesco,et al.  Heart Rate Lowering by Specific and Selective If Current Inhibition with Ivabradine , 2012, Drugs.

[4]  K. Swedberg,et al.  Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study. , 2011, European Heart Journal.

[5]  K. Swedberg,et al.  Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy , 2011, European heart journal.

[6]  D. Kass,et al.  Invasive hemodynamic assessment in heart failure. , 2011, Cardiology clinics.

[7]  M. Gold,et al.  Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial , 2011 .

[8]  R. Silber,et al.  Inotropic Effects of Ivabradine in the Mammalian Heart , 2010, Pharmacology.

[9]  Michael Böhm,et al.  Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial , 2010, The Lancet.

[10]  Michael Böhm,et al.  Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study , 2010, The Lancet.

[11]  W. Ahmad.  Ivabradine and outcomes in chronic heart failure (SHIFT): a randomized placebo-controlled study , 2010 .

[12]  K. Swedberg,et al.  Rationale and design of a randomized, double‐blind, placebo‐controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT) , 2010, European journal of heart failure.

[13]  Michael Böhm,et al.  Heart rate reduction in cardiovascular disease and therapy , 2010, Clinical Research in Cardiology.

[14]  V. Roger,et al.  Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction. , 2009, Journal of the American College of Cardiology.

[15]  M. Böhm,et al.  Heart rate reduction by I(f)-channel inhibition and its potential role in heart failure with reduced and preserved ejection fraction. , 2009, Trends in cardiovascular medicine.

[16]  D. Burkhoff,et al.  Mechanisms Underlying Improvements in Ejection Fraction With Carvedilol in Heart Failure , 2009, Circulation. Heart failure.

[17]  J. Blacher,et al.  Statins, central blood pressure, and blood pressure amplification. , 2009, Circulation.

[18]  P. Schwartz,et al.  Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure ☆ , 2008, European journal of heart failure.

[19]  D. Kass,et al.  Ventricular-vascular interaction in heart failure. , 2008, Heart failure clinics.

[20]  Alice Stanton,et al.  Differential Impact of Blood Pressure–Lowering Drugs on Central Aortic Pressure and Clinical Outcomes: Principal Results of the Conduit Artery Function Evaluation (CAFE) Study , 2006, Circulation.

[21]  James B. Seward,et al.  The echo manual , 2006 .

[22]  D. Kass,et al.  Age- and Gender-Related Ventricular-Vascular Stiffening: A Community-Based Study , 2005, Circulation.

[23]  P. Challande,et al.  Selective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats , 2004, Journal of hypertension.

[24]  F. Lallemand,et al.  Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure , 2004, Circulation.

[25]  L. Hittinger,et al.  Effect of Graded Heart Rate Reduction with Ivabradine on Myocardial Oxygen Consumption and Diastolic Time in Exercising Dogs , 2004, Journal of Pharmacology and Experimental Therapeutics.

[26]  Dario DiFrancesco,et al.  Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. , 2004, Drugs.

[27]  G. Mancia,et al.  Effects of Heart Rate Changes on Arterial Distensibility in Humans , 2003, Hypertension.

[28]  M. Safar,et al.  Effect of Chronic Heart Rate Reduction with Ivabradine on Carotid and Aortic Structure and Function in Normotensive and Hypertensive Rats , 2003, Journal of Vascular Research.

[29]  D. Kass,et al.  Combined Ventricular Systolic and Arterial Stiffening in Patients With Heart Failure and Preserved Ejection Fraction: Implications for Systolic and Diastolic Reserve Limitations , 2003, Circulation.

[30]  C H Chen,et al.  Noninvasive single-beat determination of left ventricular end-systolic elastance in humans. , 2001, Journal of the American College of Cardiology.

[31]  Yves Lecarpentier,et al.  Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. , 1998, American journal of physiology. Heart and circulatory physiology.

[32]  B. Pannier,et al.  Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects , 1997, Journal of hypertension.

[33]  G. Mancia,et al.  Heart rate-dependence of arterial distensibility in vivo , 1996, Journal of hypertension.

[34]  W C Hunter,et al.  Ventricular stroke work and efficiency both remain nearly optimal despite altered vascular loading. , 1993, The American journal of physiology.

[35]  David A. Kass,et al.  Effective Arterial Elastance as Index of Arterial Vascular Load in Humans , 1992, Circulation.

[36]  G. Freeman,et al.  Role of ventriculovascular coupling in cardiac response to increased contractility in closed-chest dogs. , 1990, The Journal of clinical investigation.

[37]  S Sasayama,et al.  Ventriculoarterial coupling in normal and failing heart in humans. , 1989, Circulation research.

[38]  W L Maughan,et al.  Left ventricular interaction with arterial load studied in isolated canine ventricle. , 1983, The American journal of physiology.