论文信息 - Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.

Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.

Quantitative relationships between skin sensitization potential and certain physico-chemical properties of alkylating agents have been reported. This study demonstrates the correlation of the relative alkylation index (RAI), derived from the alkylation rate and lipophilicity of an alkylating agent, with a set of experimental sensitization data obtained for a series of p-nitrobenzyl compounds.

[1] Joseph F. Bunnett,et al. Aromatic Nucleophilic Substitution Reactions. , 1951 .

[2] B F Goodwin,et al. A comparison of three guinea‐pig sensitization procedures for the detection of 19 reported human contact sensitizers , 1981, Contact dermatitis.

[3] S. Sugden,et al. 303. The kinetics of exchange reactions. Part IV. Substituted phenyl and benzyl bromides , 1951 .

[4] D W Roberts,et al. The derivation of quantitative correlations between skin sensitisation and physio-chemical parameters for alkylating agents, and their application to experimental data for sultones. , 1982, Journal of theoretical biology.

[5] H. Godfrey,et al. The effect of physical and chemical properties of the sensitizing substance on the induction and elicitation of delayed contact sensitivity. , 1971, Journal of immunology.

[6] C. R. Dawson,et al. Delayed contact sensitivity to catechols. II. Cutaneous toxicity of catechols chemically related to the active principles of poison ivy. , 1967, Journal of immunology.

[7] M. Sy,et al. Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide. , 1977, Journal of immunology.

[8] C. R. Dawson,et al. Delayed contact sensitivity to catechols. 3. The relationship of side-chain length to sensitizing potency of catechols chemically related to the active principles of poison ivy. , 1967, Journal of immunology.