PHOTOFRAGMENTATION OF PHOTOTOXIC DIBENZOCYCLOHEPTADIENE ANTIDEPRESSANTS

Abstract— Abstract‐The products of photochemical reaction of a family of phototoxic tricyclic antidepressants have been determined, both in the presence and absence of oxygen. Under all conditions photofrag‐mentation of the phototoxic compounds is an important reaction‐in some cases it is virtually the only photoreaction observed. The mechanism of photoreaction appears to involve excited state electron transfer from the side chain to give a reactive exciplex, which fragments via both radical and ionic pathways. These reactive intermediates are likely to contribute to the in vivo phototoxicity of these compounds.

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