Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

[1]  M. Mann,et al.  Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine. , 2019, Cell metabolism.

[2]  W. D. van Marken Lichtenbelt,et al.  Human brown adipose tissue: Underestimated target in metabolic disease? , 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[3]  B. Spiegelman,et al.  New Advances in Adaptive Thermogenesis: UCP1 and Beyond. , 2019, Cell metabolism.

[4]  F. Mulero,et al.  FGF21 gene therapy as treatment for obesity and insulin resistance , 2018, EMBO molecular medicine.

[5]  T. Strom,et al.  Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles. , 2018, Cell reports.

[6]  S. Kliewer,et al.  The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol. , 2018, Cell metabolism.

[7]  S. Kajimura,et al.  UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis , 2017, Nature Medicine.

[8]  T. Schwarzmayr,et al.  Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. , 2017, Cell metabolism.

[9]  A. Franke,et al.  Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis , 2017, Nature Medicine.

[10]  K. Kristiansen,et al.  Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype , 2017, International Journal of Obesity.

[11]  C. Schéele,et al.  Metabolic regulation and the anti-obesity perspectives of human brown fat , 2017, Redox biology.

[12]  P. Trayhurn.  Origins and early development of the concept that brown adipose tissue thermogenesis is linked to energy balance and obesity. , 2017, Biochimie.

[13]  P. Arner,et al.  An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice , 2016, Nature Medicine.

[14]  B. Spiegelman,et al.  The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria , 2016, Cell.

[15]  F. Bäckhed,et al.  Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure , 2016, Cell metabolism.

[16]  J. Heeren,et al.  FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. , 2016, Cell metabolism.

[17]  L. Kozak,et al.  Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice. , 2016, American journal of physiology. Endocrinology and metabolism.

[18]  Bhavna S. Paratala,et al.  FGF21 Regulates Sweet and Alcohol Preference. , 2016, Cell metabolism.

[19]  T. Schulz,et al.  Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action , 2015, Molecular metabolism.

[20]  B. Spiegelman,et al.  A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat , 2015, Cell.

[21]  R. Gimeno,et al.  Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. , 2015, Cell reports.

[22]  F. Neff,et al.  Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion , 2015, Molecular metabolism.

[23]  M. Véniant,et al.  Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue. , 2015, Cell metabolism.

[24]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[25]  C. Kahn,et al.  ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes , 2014, Science Translational Medicine.

[26]  S. Keipert,et al.  Brite/beige fat and UCP1 - is it thermogenesis? , 2014, Biochimica et biophysica acta.

[27]  M. Reitman,et al.  Effect of Intermittent Cold Exposure on Brown Fat Activation, Obesity, and Energy Homeostasis in Mice , 2014, PloS one.

[28]  S. Bernard,et al.  Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects , 2013, Journal of Lipid Research.

[29]  H. Fu,et al.  The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. , 2013, Cell metabolism.

[30]  Sarah L. Westcott,et al.  Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform , 2013, Applied and Environmental Microbiology.

[31]  G. Shulman,et al.  Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. , 2013, Endocrinology.

[32]  M. Borga,et al.  Evidence for two types of brown adipose tissue in humans , 2013, Nature Medicine.

[33]  R. Elvert,et al.  Energy loss via urine and faeces – a combustive analysis in diabetic rats and the impact of antidiabetic treatment on body weight , 2013, Diabetes, obesity & metabolism.

[34]  M. Mori,et al.  Anatomical Localization, Gene Expression Profiling, and Functional Characterization of Adult Human Neck Brown Fat , 2013, Nature Medicine.

[35]  Y. Mishina,et al.  Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat , 2013, Nature.

[36]  S. Kliewer,et al.  The starvation hormone, fibroblast growth factor-21, extends lifespan in mice , 2012, eLife.

[37]  H. Wyatt,et al.  Energy balance and obesity. , 2012, Circulation.

[38]  Helgi B. Schiöth,et al.  Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans , 2012, PLoS genetics.

[39]  B. Spiegelman,et al.  FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. , 2012, Genes & development.

[40]  B. Haas,et al.  Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. , 2011, Genome research.

[41]  F. Villarroya,et al.  Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue* , 2011, The Journal of Biological Chemistry.

[42]  Paramvir S. Dehal,et al.  FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments , 2010, PloS one.

[43]  J. Orava,et al.  Functional brown adipose tissue in healthy adults. , 2009, The New England journal of medicine.

[44]  W. D. van Marken Lichtenbelt,et al.  Cold-activated brown adipose tissue in healthy men. , 2009, The New England journal of medicine.

[45]  Rob Knight,et al.  PyNAST: a flexible tool for aligning sequences to a template alignment , 2009, Bioinform..

[46]  M. Miyagawa,et al.  High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans , 2009, Diabetes.

[47]  B. Cannon,et al.  UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. , 2009, Cell metabolism.

[48]  L. Kozak,et al.  UCP1: its involvement and utility in obesity , 2008, International Journal of Obesity.

[49]  D. Moller,et al.  Fibroblast growth factor 21 corrects obesity in mice. , 2008, Endocrinology.

[50]  J. Ukropec,et al.  Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity* , 2008, Journal of Biological Chemistry.

[51]  T. Bengtsson,et al.  Unexpected evidence for active brown adipose tissue in adult humans. , 2007, American journal of physiology. Endocrinology and metabolism.

[52]  J. Tiedje,et al.  Naïve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy , 2007, Applied and Environmental Microbiology.

[53]  K. Rosenblatt,et al.  βKlotho is required for metabolic activity of fibroblast growth factor 21 , 2007, Proceedings of the National Academy of Sciences.

[54]  Eoin L. Brodie,et al.  Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB , 2006, Applied and Environmental Microbiology.

[55]  M. Rossmeisl,et al.  Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. , 2003, The Journal of clinical investigation.

[56]  M. Lazar,et al.  A futile metabolic cycle activated in adipocytes by antidiabetic agents , 2002, Nature Medicine.

[57]  L. Tecott.  Faculty Opinions recommendation of betaAR signaling required for diet-induced thermogenesis and obesity resistance. , 2002 .

[58]  B. Lowell,et al.  βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance , 2002, Science.

[59]  B. Lowell,et al.  Development of obesity in transgenic mice after genetic ablation of brown adipose tissue , 1993, Nature.

[60]  Franks,et al.  Prevalence of overweight and obesity and double burden of malnutrition , 2017 .

[61]  F. Villarroya,et al.  Brown adipose tissue as a secretory organ , 2017, Nature Reviews Endocrinology.

[62]  K. Kristiansen,et al.  Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype , 2017, International Journal of Obesity.

[63]  Russ B. Altman,et al.  Genome Analysis , 2011, Bioinform..

[64]  Jan Nedergaard,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[65]  The Wenner-Gren Institute,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[66]  Robert C. Edgar,et al.  BIOINFORMATICS APPLICATIONS NOTE , 2001 .

[67]  D. Nicholls,et al.  Thermogenic mechanisms in brown fat. , 1984, Physiological reviews.